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CFAP20 cilia and flagella associated protein 20 [ Homo sapiens (human) ]

Gene ID: 29105, updated on 17-Jun-2024

Summary

Official Symbol
CFAP20provided by HGNC
Official Full Name
cilia and flagella associated protein 20provided by HGNC
Primary source
HGNC:HGNC:29523
See related
Ensembl:ENSG00000070761 MIM:617906; AllianceGenome:HGNC:29523
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GTL3; BUG22; EVORF; fSAP23; C16orf80
Summary
Enables RNA binding activity. Involved in several processes, including positive regulation of feeding behavior; protein polyglutamylation; and regulation of cell motility. Located in centriole; ciliary basal body; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 19.9), placenta (RPKM 16.9) and 25 other tissues See more
Orthologs
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Genomic context

See CFAP20 in Genome Data Viewer
Location:
16q21
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (58113592..58129381, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (63908917..63925035, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (58147496..58163285, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:58059673-58060222 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:58060773-58061322 Neighboring gene matrix metallopeptidase 15 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:58119688-58120378 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:58131910-58132410 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:58132411-58132911 Neighboring gene TIPIN pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10921 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7543 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:58162549-58163470 Neighboring gene uncharacterized LOC101927556 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:58163471-58164391 Neighboring gene casein kinase 2 alpha 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7545 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7546 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7547 Neighboring gene RNA, 7SL, cytoplasmic 645, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in axonemal B tubule inner sheath IEA
Inferred from Electronic Annotation
more info
 
located_in axonemal microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in axonemal microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
is_active_in motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
cilia- and flagella-associated protein 20
Names
UPF0468 protein C16orf80
basal body up-regulated protein 22
flagellar associated protein 20 homolog
functional spliceosome-associated protein 23
gene trap locus 3
transcription factor IIB

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013242.3NP_037374.1  cilia- and flagella-associated protein 20

    See identical proteins and their annotated locations for NP_037374.1

    Status: VALIDATED

    Source sequence(s)
    AV751497, BC005152
    Consensus CDS
    CCDS10793.1
    UniProtKB/Swiss-Prot
    Q9Y6A4
    UniProtKB/TrEMBL
    B4DN94
    Related
    ENSP00000262498.3, ENST00000262498.8
    Conserved Domains (1) summary
    pfam05018
    Location:1185
    DUF667; Protein of unknown function (DUF667)

RNA

  1. NR_136632.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC026771, AI379428, BU730963, CN364433, HY042096
    Related
    ENST00000562622.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    58113592..58129381 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    63908917..63925035 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)