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Nedd9 neural precursor cell expressed, developmentally down-regulated 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 291044, updated on 11-Apr-2024

Summary

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Official Symbol
Nedd9provided by RGD
Official Full Name
neural precursor cell expressed, developmentally down-regulated 9provided by RGD
Primary source
RGD:1306276
See related
Ensembl:ENSRNOG00000014548 AllianceGenome:RGD:1306276
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein tyrosine kinase binding activity. Predicted to be involved in several processes, including actin filament reorganization; positive regulation of protein tyrosine kinase activity; and positive regulation of substrate adhesion-dependent cell spreading. Predicted to act upstream of or within activation of GTPase activity. Predicted to be located in cytosol; nucleoplasm; and spindle pole. Predicted to be active in cytoplasm. Predicted to colocalize with plasma membrane. Orthologous to human NEDD9 (neural precursor cell expressed, developmentally down-regulated 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 451.0), Spleen (RPKM 243.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nedd9 in Genome Data Viewer
Location:
17p12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (23495531..23673780)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (23289793..23468026)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (22984792..23179701)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 170B Neighboring gene uncharacterized LOC134482837 Neighboring gene uncharacterized LOC134482836 Neighboring gene uncharacterized LOC102548345 Neighboring gene small integral membrane protein 13 Neighboring gene small integral membrane protein 13 like Neighboring gene microRNA 3566

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Retinoic acid regulates Schwann cell migration via NEDD9 induction by transcriptional and post-translational mechanisms. Latasa MJ, et al. Biochim Biophys Acta, 2016 Jul. PMID 27085739
  2. Nedd9 protein, a Cas-L homologue, is upregulated after transient global ischemia in rats: possible involvement of Nedd9 in the differentiation of neurons after ischemia. Sasaki T, et al. Stroke, 2005 Nov. PMID 16210561
  3. Crk-associated substrate (Cas) family member, NEDD9, is regulated in human neuroblastoma cells and in the embryonic hindbrain by all-trans retinoic acid. Merrill RA, et al. Dev Dyn, 2004 Nov. PMID 15376324
  4. A novel Cas family member, HEPL, regulates FAK and cell spreading. Singh MK, et al. Mol Biol Cell, 2008 Apr. PMID 18256281, Free PMC Article
  5. CRK proteins selectively regulate T cell migration into inflamed tissues. Huang Y, et al. J Clin Invest, 2015 Mar 2. PMID 25621495, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Retinoic acid regulates Schwann cell migration by inducing NEDD9 levels by both transcriptional and post-translational mechanisms.
    Title: Retinoic acid regulates Schwann cell migration via NEDD9 induction by transcriptional and post-translational mechanisms.
  2. Nedd9 has a role in the differentiation of neurons after ischemia
    Title: Nedd9 protein, a Cas-L homologue, is upregulated after transient global ischemia in rats: possible involvement of Nedd9 in the differentiation of neurons after ischemia.
  3. Nedd9_predicted is regulated in the embryonic hindbrain by all-trans retinoic acid.
    Title: Crk-associated substrate (Cas) family member, NEDD9, is regulated in human neuroblastoma cells and in the embryonic hindbrain by all-trans retinoic acid.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in learning or memory ISO
Inferred from Sequence Orthology
more info
  
involved_in lymphocyte migration into lymphoid organs ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of dendritic spine maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of immunological synapse formation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of lymphocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in immunological synapse ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
enhancer of filamentation 1
Names
neural precursor cell expressed, developmentally down-regulated gene 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011922.3 → NP_001011922.1  enhancer of filamentation 1

    See identical proteins and their annotated locations for NP_001011922.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A6J767, F7F3Z5, Q5U2Y4
    Related
    ENSRNOP00000060831.1, ENSRNOT00000067374.3
    Conserved Domains (3) summary
    cd12002
    Location:7 → 63
    SH3_NEDD9; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member, Neural precursor cell Expressed, Developmentally Down-regulated 9
    pfam12026
    Location:620 → 827
    DUF3513; Domain of unknown function (DUF3513)
    cl07433
    Location:400 → 561
    Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    23495531..23673780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253786.5 → XP_006253848.1  enhancer of filamentation 1 isoform X1

    See identical proteins and their annotated locations for XP_006253848.1

    UniProtKB/TrEMBL
    A0A0G2JZL7, A6J766
    Related
    ENSRNOP00000071096.2
    Conserved Domains (3) summary
    cd12002
    Location:7 → 63
    SH3_NEDD9; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member, Neural precursor cell Expressed, Developmentally Down-regulated 9
    pfam12026
    Location:620 → 827
    DUF3513; Domain of unknown function (DUF3513)
    cl07433
    Location:400 → 561
    Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module

  2. XM_039095477.2 → XP_038951405.1  enhancer of filamentation 1 isoform X2

    Conserved Domains (3) summary
    cd12002
    Location:1 → 57
    SH3_NEDD9; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member, Neural precursor cell Expressed, Developmentally Down-regulated 9
    pfam12026
    Location:614 → 821
    DUF3513; Domain of unknown function (DUF3513)
    cl07433
    Location:394 → 555
    Serine_rich_CAS; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module
Nucleotide Protein Strain
Heading Accession and Version

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