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Id4 inhibitor of DNA binding 4, HLH protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 291023, updated on 30-Sep-2021

Summary

Official Symbol
Id4provided by RGD
Official Full Name
inhibitor of DNA binding 4, HLH proteinprovided by RGD
Primary source
RGD:631428
See related
EnsemblRapid:ENSRNOG00000016099
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Idb4
Summary
involved in the regulation of basic HLH transcription factors; may play a role in mammary gland carcinogenesis [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 322.2), Liver (RPKM 173.4) and 9 other tissues See more
Orthologs
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Genomic context

See Id4 in Genome Data Viewer
Location:
17p14
Exon count:
3
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (16389387..16391956, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (16692557..16695126, complement)

Chromosome 17 - NC_051352.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097935 Neighboring gene uncharacterized LOC108348525 Neighboring gene microRNA let-7d Neighboring gene microRNA 3596b Neighboring gene zinc finger protein 169 Neighboring gene uncharacterized LOC120097866 Neighboring gene uncharacterized LOC108348527 Neighboring gene uncharacterized LOC102546683

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription regulator inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within brain development ISO
Inferred from Sequence Orthology
more info
 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cellular protein localization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within central nervous system myelination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cerebral cortex neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in circadian regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hippocampus development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of astrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within prostate gland epithelium morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within prostate gland morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within prostate gland stromal morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within seminal vesicle morphogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA-binding protein inhibitor ID-4
Names
inhibitor of DNA binding 4, dominant negative helix-loop-helix protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175582.2NP_783172.2  DNA-binding protein inhibitor ID-4

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000288
    Related
    ENSRNOP00000021550.2, ENSRNOT00000021550.3
    Conserved Domains (1) summary
    cd19694
    Location:62117
    bHLH_dnHLH_ID4; basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID4 and similar proteins

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051352.1 Reference mRatBN7.2 Primary Assembly

    Range
    16389387..16391956 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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