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COMMD9 COMM domain containing 9 [ Homo sapiens (human) ]

Gene ID: 29099, updated on 8-Nov-2020

Summary

Official Symbol
COMMD9provided by HGNC
Official Full Name
COMM domain containing 9provided by HGNC
Primary source
HGNC:HGNC:25014
See related
Ensembl:ENSG00000110442 MIM:612299
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSPC166; C11orf55; LINC00610
Expression
Ubiquitous expression in bone marrow (RPKM 8.8), brain (RPKM 7.8) and 25 other tissues See more
Orthologs

Genomic context

See COMMD9 in Genome Data Viewer
Location:
11p13
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (36272292..36289428, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (36293842..36310999, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor class A domain containing 3 Neighboring gene microRNA 3973 Neighboring gene uncharacterized LOC101928510 Neighboring gene proline rich 5 like Neighboring gene TNF receptor associated factor 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31106, FLJ45212

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cholesterol homeostasis IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
secretory granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
COMM domain-containing protein 9

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101653.2NP_001095123.1  COMM domain-containing protein 9 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC087277
    Consensus CDS
    CCDS44571.1
    UniProtKB/TrEMBL
    Q53FR9
    Related
    ENSP00000392510.2, ENST00000452374.6
    Conserved Domains (1) summary
    cd04757
    Location:48155
    Commd9; COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...
  2. NM_001307932.2NP_001294861.1  COMM domain-containing protein 9 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 3' coding region, which causes a frameshift compared to variant 1. It encodes isoform 3, which is shorter than and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC087277
    Consensus CDS
    CCDS76395.1
    UniProtKB/TrEMBL
    E9PJ95, Q53FR9
    Related
    ENSP00000435599.1, ENST00000532705.1
    Conserved Domains (1) summary
    cl06336
    Location:16105
    Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
  3. NM_001307937.2NP_001294866.1  COMM domain-containing protein 9 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate exon in the 5' coding region, which results in use of an alternate start codon compared to variant 1. It encodes isoform 4, which is shorter than and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC087277
    UniProtKB/Swiss-Prot
    Q9P000
    UniProtKB/TrEMBL
    Q53FR9
    Conserved Domains (1) summary
    cd04757
    Location:81188
    Commd9; COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...
  4. NM_014186.4NP_054905.2  COMM domain-containing protein 9 isoform 1

    See identical proteins and their annotated locations for NP_054905.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC087277
    Consensus CDS
    CCDS7900.1
    UniProtKB/Swiss-Prot
    Q9P000
    UniProtKB/TrEMBL
    Q53FR9
    Related
    ENSP00000263401.5, ENST00000263401.10
    Conserved Domains (1) summary
    cd04757
    Location:90197
    Commd9; COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    36272292..36289428 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017625.1XP_016873114.1  COMM domain-containing protein 9 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_207428.2: Suppressed sequence

    Description
    NM_207428.2: This RefSeq was permanently suppressed because it is mostly repetitive sequence.
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