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RANGRF RAN guanine nucleotide release factor [ Homo sapiens (human) ]

Gene ID: 29098, updated on 13-Mar-2020

Summary

Official Symbol
RANGRFprovided by HGNC
Official Full Name
RAN guanine nucleotide release factorprovided by HGNC
Primary source
HGNC:HGNC:17679
See related
Ensembl:ENSG00000108961 MIM:607954
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MOG1; HSPC165; HSPC236; RANGNRF
Summary
This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Expression
Broad expression in testis (RPKM 13.3), endometrium (RPKM 7.1) and 24 other tissues See more
Orthologs

Genomic context

See RANGRF in Genome Data Viewer
Location:
17p13.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (8288670..8290087)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8191745..8193409)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tRNA-Ile (anticodon AAT) 4-1 Neighboring gene CST telomere replication complex component 1 Neighboring gene phosphoribosylformylglycinamidine synthase Neighboring gene solute carrier family 25 member 35 Neighboring gene CRISPRi-validated cis-regulatory element chr17.641 Neighboring gene Rho guanine nucleotide exchange factor 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC110973, DKFZp686F02139

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Ran GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Ran GTPase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Ran guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
ion channel binding IPI
Inferred from Physical Interaction
more info
PubMed 
sodium channel regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
sodium channel regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein localization to cell surface IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein localization to cell surface IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein exit from endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of bundle of His cell action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cardiac muscle cell action potential involved in regulation of contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of heart rate TAS
Traceable Author Statement
more info
PubMed 
regulation of membrane depolarization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of membrane depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of membrane depolarization during cardiac muscle cell action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of membrane depolarization during cardiac muscle cell action potential TAS
Traceable Author Statement
more info
PubMed 
regulation of membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
regulation of microtubule nucleation by Ran protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of sodium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
regulation of sodium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of sodium ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of sodium ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
caveola IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
intercalated disc ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IC
Inferred by Curator
more info
PubMed 
rough endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ran guanine nucleotide release factor
Names
MOG1 homolog
ran-binding protein MOG1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028189.1 RefSeqGene

    Range
    5020..6437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001177801.2NP_001171272.1  ran guanine nucleotide release factor isoform B

    See identical proteins and their annotated locations for NP_001171272.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate segment in the coding region, resulting in a frameshift, compared to variant (1). It encodes isoform B, which has a shorter C-terminus, compared to isoform A.
    Source sequence(s)
    AF265205, CN396019
    Consensus CDS
    CCDS54086.1
    UniProtKB/Swiss-Prot
    Q9HD47
    Related
    ENSP00000383940.4, ENST00000407006.8
    Conserved Domains (1) summary
    cd00224
    Location:7146
    Mog1; homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important role in nuclear import. Binding is independent of Ran's nucleotide state (RanGTP/RanGDP)
  2. NM_001177802.2NP_001171273.1  ran guanine nucleotide release factor isoform C

    See identical proteins and their annotated locations for NP_001171273.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes an alternate segment in the coding region, resulting in a frameshift, compared to variant (1). It encodes isoform C, which has a shorter and distinct C-terminus, compared to isoform A.
    Source sequence(s)
    AC135178, BC006486, CN396019
    Consensus CDS
    CCDS54087.1
    UniProtKB/Swiss-Prot
    Q9HD47
    Related
    ENSP00000413190.3, ENST00000439238.3
    Conserved Domains (1) summary
    cl00169
    Location:7119
    Mog1; homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important role in nuclear import. Binding is independent of Ran's nucleotide state (RanGTP/RanGDP)
  3. NM_001330127.2NP_001317056.1  ran guanine nucleotide release factor isoform D

    Status: REVIEWED

    Source sequence(s)
    AC135178, CR749387, HY034192
    Consensus CDS
    CCDS82066.1
    UniProtKB/Swiss-Prot
    Q9HD47
    Related
    ENSP00000462310.1, ENST00000580434.5
    Conserved Domains (1) summary
    cl00169
    Location:7117
    Mog1; homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important role in nuclear import. Binding is independent of Ran's nucleotide state (RanGTP/RanGDP)
  4. NM_016492.5NP_057576.2  ran guanine nucleotide release factor isoform A

    See identical proteins and their annotated locations for NP_057576.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the longest isoform (A).
    Source sequence(s)
    AF265206, CN396019
    Consensus CDS
    CCDS11137.1
    UniProtKB/Swiss-Prot
    Q9HD47
    Related
    ENSP00000226105.6, ENST00000226105.11
    Conserved Domains (1) summary
    cd00224
    Location:7184
    Mog1; homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important role in nuclear import. Binding is independent of Ran's nucleotide state (RanGTP/RanGDP)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    8288670..8290087
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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