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RANGRF RAN guanine nucleotide release factor [ Homo sapiens (human) ]

Gene ID: 29098, updated on 23-Nov-2021

Summary

Official Symbol
RANGRFprovided by HGNC
Official Full Name
RAN guanine nucleotide release factorprovided by HGNC
Primary source
HGNC:HGNC:17679
See related
Ensembl:ENSG00000108961 MIM:607954
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MOG1; HSPC165; HSPC236; RANGNRF
Summary
This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Expression
Broad expression in testis (RPKM 13.3), endometrium (RPKM 7.1) and 24 other tissues See more
Orthologs
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Genomic context

See RANGRF in Genome Data Viewer
Location:
17p13.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (8288670..8290087)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8191988..8193405)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tRNA-Ile (anticodon AAT) 4-1 Neighboring gene CST telomere replication complex component 1 Neighboring gene phosphoribosylformylglycinamidine synthase Neighboring gene solute carrier family 25 member 35 Neighboring gene CRISPRi-validated cis-regulatory element chr17.641 Neighboring gene Rho guanine nucleotide exchange factor 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC110973, DKFZp686F02139

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables sodium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sodium channel regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sodium channel regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of protein localization to cell surface IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein localization to cell surface IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein exit from endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of bundle of His cell action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cardiac muscle cell action potential involved in regulation of contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of heart rate TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of membrane depolarization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of membrane depolarization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of membrane depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of membrane depolarization during cardiac muscle cell action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of membrane depolarization during cardiac muscle cell action potential TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of microtubule nucleation by Ran protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of sodium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of sodium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of sodium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of sodium ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of sodium ion transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in caveola IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in intercalated disc ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IC
Inferred by Curator
more info
PubMed 
located_in rough endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ran guanine nucleotide release factor
Names
MOG1 homolog
ran-binding protein MOG1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028189.1 RefSeqGene

    Range
    5020..6437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001177801.2NP_001171272.1  ran guanine nucleotide release factor isoform B

    See identical proteins and their annotated locations for NP_001171272.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate segment in the coding region, resulting in a frameshift, compared to variant (1). It encodes isoform B, which has a shorter C-terminus, compared to isoform A.
    Source sequence(s)
    AF265205, CN396019
    Consensus CDS
    CCDS54086.1
    UniProtKB/Swiss-Prot
    Q9HD47
    Related
    ENSP00000383940.4, ENST00000407006.8
    Conserved Domains (1) summary
    cd00224
    Location:7146
    Mog1; homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important role in nuclear import. Binding is independent of Ran's nucleotide state (RanGTP/RanGDP)
  2. NM_001177802.2NP_001171273.1  ran guanine nucleotide release factor isoform C

    See identical proteins and their annotated locations for NP_001171273.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes an alternate segment in the coding region, resulting in a frameshift, compared to variant (1). It encodes isoform C, which has a shorter and distinct C-terminus, compared to isoform A.
    Source sequence(s)
    AC135178, BC006486, CN396019
    Consensus CDS
    CCDS54087.1
    UniProtKB/Swiss-Prot
    Q9HD47
    Related
    ENSP00000413190.3, ENST00000439238.3
    Conserved Domains (1) summary
    cl00169
    Location:7119
    Mog1; homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important role in nuclear import. Binding is independent of Ran's nucleotide state (RanGTP/RanGDP)
  3. NM_001330127.2NP_001317056.1  ran guanine nucleotide release factor isoform D

    Status: REVIEWED

    Source sequence(s)
    AC135178, CR749387, HY034192
    Consensus CDS
    CCDS82066.1
    UniProtKB/Swiss-Prot
    Q9HD47
    Related
    ENSP00000462310.1, ENST00000580434.5
    Conserved Domains (1) summary
    cl00169
    Location:7117
    Mog1; homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important role in nuclear import. Binding is independent of Ran's nucleotide state (RanGTP/RanGDP)
  4. NM_016492.5NP_057576.2  ran guanine nucleotide release factor isoform A

    See identical proteins and their annotated locations for NP_057576.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the longest isoform (A).
    Source sequence(s)
    AF265206, CN396019
    Consensus CDS
    CCDS11137.1
    UniProtKB/Swiss-Prot
    Q9HD47
    Related
    ENSP00000226105.6, ENST00000226105.11
    Conserved Domains (1) summary
    cd00224
    Location:7184
    Mog1; homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important role in nuclear import. Binding is independent of Ran's nucleotide state (RanGTP/RanGDP)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    8288670..8290087
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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