LGALSL galectin like [Homo sapiens (human)] - Gene

Summary

Official Symbol: LGALSLprovided by HGNC
Official Full Name: galectin likeprovided by HGNC
Primary source: HGNC:HGNC:25012
See related: Ensembl:ENSG00000119862 MIM:617902; AllianceGenome:HGNC:25012
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GRP; HSPC159
Summary: Predicted to enable carbohydrate binding activity. [provided by Alliance of Genome Resources, Jan 2025]
Expression: Broad expression in skin (RPKM 47.6), esophagus (RPKM 15.3) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2p14

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (64454162..64461381)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (64462631..64470536)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (64681296..64688515)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

our findings showed that HSPC159 contributed to breast cancer progression through the PI3K/Akt pathway
Title: HSPC159 promotes proliferation and metastasis by inducing epithelial-mesenchymal transition and activating the PI3K/Akt pathway in breast cancer.
Galectin-related protein is a novel protein that has a close similarity to galectin sequences but is not a member of the galectin family because of its lack of lactose-binding activity. The crystal structure has been solved.
Title: Crystal structure of the C-terminal conserved domain of human GRP, a galectin-related protein, reveals a function mode different from those of galectins.
CCL13 and HSPC159 mRNA expressions in PBMC are up-regulated specifically in MCNS patients during the nephrosis phase.
Title: Gene expression profiling of peripheral blood mononuclear cells from patients with minimal change nephrotic syndrome by cDNA microarrays.
Galectin-related protein named GRP comprises only one conserved carbohydrate-recognition domain with 38 additional N-terminal residues. The crystals belong to the monoclinic space group C2.
Title: Expression, purification, crystallization and preliminary X-ray characterization of the GRP carbohydrate-recognition domain from Homo sapiens.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH80132 (e-PCR)
- UniSTS:90626

SHGC-37647 (e-PCR)
- UniSTS:6468

HSPC159_9577 (e-PCR)
- UniSTS:471465

RH11927 (e-PCR)
- UniSTS:71129

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables carbohydrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: galectin-related protein

Names: galectin-like protein; lectin galactoside-binding-like protein; lectin, galactoside binding like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.