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TIMM21 translocase of inner mitochondrial membrane 21 [ Homo sapiens (human) ]

Gene ID: 29090, updated on 17-Jun-2024

Summary

Official Symbol
TIMM21provided by HGNC
Official Full Name
translocase of inner mitochondrial membrane 21provided by HGNC
Primary source
HGNC:HGNC:25010
See related
Ensembl:ENSG00000075336 MIM:615180; AllianceGenome:HGNC:25010
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIM21; HSPC154; C18orf55
Summary
Involved in mitochondrial cytochrome c oxidase assembly; mitochondrial respiratory chain complex I assembly; and protein import into mitochondrial matrix. Part of TIM23 mitochondrial import inner membrane translocase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart (RPKM 23.3), kidney (RPKM 13.3) and 25 other tissues See more
Orthologs
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Genomic context

See TIMM21 in Genome Data Viewer
Location:
18q22.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (74148523..74160531)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (74369489..74381497)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (71815758..71827766)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904358 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_50059 Neighboring gene Sharpr-MPRA regulatory region 9472 Neighboring gene F-box protein 15 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9541 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13491 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13492 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13493 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:71817752-71818951 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:71822138-71823337 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13494 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_50247 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:71864836-71865492 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:71904867-71905366 Neighboring gene RNA, 7SL, cytoplasmic 551, pseudogene Neighboring gene Sharpr-MPRA regulatory region 12176 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr18:71917515-71918450 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:71935092-71935632 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_50263 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_50279 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:71948314-71948841 Neighboring gene cytochrome b5 type A Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_50293 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:71957777-71958384 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_50301

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
mitochondrial import inner membrane translocase subunit Tim21
Names
TIM21-like protein, mitochondrial
translocase of inner mitochondrial membrane 21 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014177.3NP_054896.2  mitochondrial import inner membrane translocase subunit Tim21 precursor

    See identical proteins and their annotated locations for NP_054896.2

    Status: VALIDATED

    Source sequence(s)
    AC084702, BC000892, BG431414, BG820086
    Consensus CDS
    CCDS12003.1
    UniProtKB/Swiss-Prot
    Q9BVV7, Q9P010
    UniProtKB/TrEMBL
    A8K1K8
    Related
    ENSP00000169551.6, ENST00000169551.11
    Conserved Domains (1) summary
    pfam08294
    Location:100244
    TIM21; TIM21

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    74148523..74160531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266689.5XP_005266746.1  mitochondrial import inner membrane translocase subunit Tim21 isoform X1

    Conserved Domains (1) summary
    cl21648
    Location:74195
    Coa1; Cytochrome oxidase complex assembly protein 1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    74369489..74381497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054318544.1XP_054174519.1  mitochondrial import inner membrane translocase subunit Tim21 isoform X1