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TIMM21 translocase of inner mitochondrial membrane 21 [ Homo sapiens (human) ]

Gene ID: 29090, updated on 1-Aug-2020

Summary

Official Symbol
TIMM21provided by HGNC
Official Full Name
translocase of inner mitochondrial membrane 21provided by HGNC
Primary source
HGNC:HGNC:25010
See related
Ensembl:ENSG00000075336 MIM:615180
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIM21; HSPC154; C18orf55
Expression
Ubiquitous expression in heart (RPKM 23.3), kidney (RPKM 13.3) and 25 other tissues See more
Orthologs

Genomic context

See TIMM21 in Genome Data Viewer
Location:
18q22.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (74148517..74160531)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (71815746..71826204)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372191 Neighboring gene F-box protein 15 Neighboring gene RNA, 7SL, cytoplasmic 551, pseudogene Neighboring gene cytochrome b5 type A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
mitochondrial respiratory chain complex I assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrial respiratory chain complex IV assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein import into mitochondrial matrix IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
TIM23 mitochondrial import inner membrane translocase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
TIM23 mitochondrial import inner membrane translocase complex IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mitochondrial import inner membrane translocase subunit Tim21
Names
TIM21-like protein, mitochondrial
translocase of inner mitochondrial membrane 21 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014177.3NP_054896.2  mitochondrial import inner membrane translocase subunit Tim21 precursor

    See identical proteins and their annotated locations for NP_054896.2

    Status: VALIDATED

    Source sequence(s)
    AC084702, BC000892, BG431414, BG820086
    Consensus CDS
    CCDS12003.1
    UniProtKB/Swiss-Prot
    Q9BVV7
    UniProtKB/TrEMBL
    A8K1K8
    Related
    ENSP00000169551.6, ENST00000169551.11
    Conserved Domains (1) summary
    pfam08294
    Location:100244
    TIM21; TIM21

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    74148517..74160531
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266689.4XP_005266746.1  mitochondrial import inner membrane translocase subunit Tim21 isoform X1

    Conserved Domains (1) summary
    cl21648
    Location:74195
    Coa1; Cytochrome oxidase complex assembly protein 1
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