Format

Send to:

Choose Destination

ARHGAP35 Rho GTPase activating protein 35 [ Homo sapiens (human) ]

Gene ID: 2909, updated on 24-Nov-2020

Summary

Official Symbol
ARHGAP35provided by HGNC
Official Full Name
Rho GTPase activating protein 35provided by HGNC
Primary source
HGNC:HGNC:4591
See related
Ensembl:ENSG00000160007 MIM:605277
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GRF-1; GRLF1; P190A; P190-A; p190RhoGAP; p190ARhoGAP
Summary
The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 28.9), brain (RPKM 18.7) and 25 other tissues See more
Orthologs

Genomic context

See ARHGAP35 in Genome Data Viewer
Location:
19q13.32
Exon count:
9
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (46860997..47005077)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47421824..47508334)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene small NF90 (ILF3) associated RNA E Neighboring gene adaptor related protein complex 2 subunit sigma 1 Neighboring gene neuronal PAS domain protein 1 Neighboring gene transmembrane protein 160

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env The 3S motif of HIV-1 gp41 activates p190 RhoGAP PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1722, MGC10745

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activator activity TAS
Traceable Author Statement
more info
 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
axonal fasciculation ISS
Inferred from Sequence or Structural Similarity
more info
 
camera-type eye development IEA
Inferred from Electronic Annotation
more info
 
cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to extracellular stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
central nervous system neuron axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
establishment or maintenance of actin cytoskeleton polarity ISS
Inferred from Sequence or Structural Similarity
more info
 
forebrain development IEA
Inferred from Electronic Annotation
more info
 
mammary gland development ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of Rho protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of vascular permeability IEA
Inferred from Electronic Annotation
more info
 
neural tube closure IEA
Inferred from Electronic Annotation
more info
 
neuron projection guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of actin polymerization or depolymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
wound healing, spreading of cells ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
ciliary basal body ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rho GTPase-activating protein 35
Names
glucocorticoid receptor DNA-binding factor 1
glucocorticoid receptor repression factor 1
rho GAP p190A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047014.2 RefSeqGene

    Range
    5001..149081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004491.5NP_004482.4  rho GTPase-activating protein 35

    See identical proteins and their annotated locations for NP_004482.4

    Status: REVIEWED

    Source sequence(s)
    AB051509, AC008755, AC008895, BE871213, CA429690, CX163309
    Consensus CDS
    CCDS46127.1
    UniProtKB/Swiss-Prot
    Q9NRY4
    Related
    ENSP00000500409.1, ENST00000672722.1
    Conserved Domains (4) summary
    smart00441
    Location:431483
    FF; Contains two conserved F residues
    smart00173
    Location:158250
    RAS; Ras subfamily of RAS small GTPases
    cd04373
    Location:12471431
    RhoGAP_p190; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an ...
    pfam16512
    Location:261340
    RhoGAP-FF1; p190-A and -B Rho GAPs FF domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    46860997..47005077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451473.1XP_024307241.1  rho GTPase-activating protein 35 isoform X1

    Conserved Domains (4) summary
    smart00441
    Location:431483
    FF; Contains two conserved F residues
    cl02570
    Location:12471380
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
    pfam16512
    Location:261340
    RhoGAP-FF1; p190-A and -B Rho GAPs FF domain
    cl27030
    Location:158250
    Ras; Ras family

RNA

  1. XR_002958305.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_024342.1: Suppressed sequence

    Description
    NM_024342.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
Support Center