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MRPL15 mitochondrial ribosomal protein L15 [ Homo sapiens (human) ]

Gene ID: 29088, updated on 2-Mar-2021

Summary

Official Symbol
MRPL15provided by HGNC
Official Full Name
mitochondrial ribosomal protein L15provided by HGNC
Primary source
HGNC:HGNC:14054
See related
Ensembl:ENSG00000137547 MIM:611828
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L15mt; RPML7; MRP-L7; HSPC145; MRP-L15
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL15 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 15q. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in heart (RPKM 21.7), kidney (RPKM 16.2) and 25 other tissues See more
Orthologs
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Genomic context

See MRPL15 in Genome Data Viewer
Location:
8q11.23
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (54135224..54148514)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (55047801..55061074)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375839 Neighboring gene lysophospholipase 1 Neighboring gene teratocarcinoma-derived growth factor 1 pseudogene 5 Neighboring gene RNA, U6atac small nuclear 32, pseudogene Neighboring gene Sharpr-MPRA regulatory region 5071 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
39S ribosomal protein L15, mitochondrial
Names
mitochondrial large ribosomal subunit protein uL15m
NP_054894.1
XP_016868851.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014175.4NP_054894.1  39S ribosomal protein L15, mitochondrial

    See identical proteins and their annotated locations for NP_054894.1

    Status: REVIEWED

    Source sequence(s)
    BC000891, BM510276, DA504537
    Consensus CDS
    CCDS6158.1
    UniProtKB/Swiss-Prot
    Q9P015
    Related
    ENSP00000260102.4, ENST00000260102.9
    Conserved Domains (1) summary
    pfam00828
    Location:53176
    Ribosomal_L27A; Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    54135224..54148514
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013362.2XP_016868851.1  39S ribosomal protein L15, mitochondrial isoform X1

    Related
    ENSP00000428581.1, ENST00000519831.5
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