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MRPL15 mitochondrial ribosomal protein L15 [ Homo sapiens (human) ]

Gene ID: 29088, updated on 9-Jun-2025
Official Symbol
MRPL15provided by HGNC
Official Full Name
mitochondrial ribosomal protein L15provided by HGNC
Primary source
HGNC:HGNC:14054
See related
Ensembl:ENSG00000137547 MIM:611828; AllianceGenome:HGNC:14054
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L15mt; RPML7; uL15m; MRP-L7; HSPC145; MRP-L15
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL15 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 15q. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in heart (RPKM 21.7), kidney (RPKM 16.2) and 25 other tissues See more
Orthologs
mouse all
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See MRPL15 in Genome Data Viewer
Location:
8q11.23
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (54135241..54148514)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (54512543..54525817)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (55047801..55061074)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene LYPLA1-TCEA1 readthrough Neighboring gene transcription elongation factor A1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19198 Neighboring gene Uncharacterized LOC133039971 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:54934747-54935540 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:54935541-54936332 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:54942814-54943544 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:54943545-54944276 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:54958280-54958473 Neighboring gene lysophospholipase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27370 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:54997169-54998116 Neighboring gene CRIPTO pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27371 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19199 Neighboring gene MPRA-validated peak7022 silencer Neighboring gene RNA, U6atac small nuclear 32, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27372 Neighboring gene Sharpr-MPRA regulatory region 5071 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 10

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. MRPL15 is a novel prognostic biomarker and therapeutic target for epithelial ovarian cancer. Xu H, et al. Cancer Med, 2021 Jun. PMID 33934540, Free PMC Article
  2. Methylation factor MRPL15 identified as a potential biological target in Alzheimer's disease. Gao L, et al. Aging (Albany NY), 2021 May 19. PMID 34016794, Free PMC Article
  3. Mammalian mitochondrial ribosomal proteins (2). Amino acid sequencing, characterization, and identification of corresponding gene sequences. O'Brien TW, et al. J Biol Chem, 1999 Dec 17. PMID 10593885
  4. A novel class of inhibitors that target SRSF10 and promote p53-mediated cytotoxicity on human colorectal cancer cells. Sohail M, et al. NAR Cancer, 2021 Jun. PMID 34316707, Free PMC Article
  5. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. Kenmochi N, et al. Genomics, 2001 Sep. PMID 11543634

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MRPL15 is a novel prognostic biomarker and therapeutic target for epithelial ovarian cancer.
    Title: MRPL15 is a novel prognostic biomarker and therapeutic target for epithelial ovarian cancer.
  2. Methylation factor MRPL15 identified as a potential biological target in Alzheimer's disease.
    Title: Methylation factor MRPL15 identified as a potential biological target in Alzheimer's disease.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of large ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
  
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial large ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HTP PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
large ribosomal subunit protein uL15m
Names
39S ribosomal protein L15, mitochondrial
mitochondrial large ribosomal subunit protein uL15m
NP_054894.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014175.4 → NP_054894.1  large ribosomal subunit protein uL15m

    See identical proteins and their annotated locations for NP_054894.1

    Status: REVIEWED

    Source sequence(s)
    BC000891, BM510276, DA504537
    Consensus CDS
    CCDS6158.1
    UniProtKB/Swiss-Prot
    Q96Q54, Q9H0Y1, Q9P015
    UniProtKB/TrEMBL
    B2R739
    Related
    ENSP00000260102.4, ENST00000260102.9
    Conserved Domains (1) summary
    pfam00828
    Location:53 → 176
    Ribosomal_L27A; Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    54135241..54148514
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    54512543..54525817
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9P015.1 GenPept UniProtKB/Swiss-Prot:Q9P015

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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