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THYN1 thymocyte nuclear protein 1 [ Homo sapiens (human) ]

Gene ID: 29087, updated on 10-Dec-2019

Summary

Official Symbol
THYN1provided by HGNC
Official Full Name
thymocyte nuclear protein 1provided by HGNC
Primary source
HGNC:HGNC:29560
See related
Ensembl:ENSG00000151500 MIM:613739
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MY105; THY28; MDS012; HSPC144; THY28KD
Summary
This gene encodes a protein that is highly conserved among vertebrates and plant species and may be involved in the induction of apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 21.0), ovary (RPKM 20.9) and 25 other tissues See more
Orthologs

Genomic context

See THYN1 in Genome Data Viewer
Location:
11q25
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (134248265..134253407, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (134118172..134123289, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene non-SMC condensin II complex subunit D3 Neighboring gene zinc finger protein 628 pseudogene Neighboring gene VPS26, retromer complex component B Neighboring gene acyl-CoA dehydrogenase family member 8 Neighboring gene galactosidase beta 1 like 3 Neighboring gene ATPase H+/K+ transporting subunit beta pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC12187

Gene Ontology Provided by GOA

Component Evidence Code Pubs
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
thymocyte nuclear protein 1
Names
thymocyte protein thy28

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037304.2NP_001032381.1  thymocyte nuclear protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001032381.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an exon in the 3' coding region, compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, compared to isoform 1. Isoform 2 is also encoded by variant 2.
    Source sequence(s)
    BC006978, BU685681, BU934600
    Consensus CDS
    CCDS8497.1
    UniProtKB/Swiss-Prot
    Q9P016
    Conserved Domains (1) summary
    cl00728
    Location:57160
    EVE; EVE domain
  2. NM_001037305.2NP_001032382.1  thymocyte nuclear protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001032382.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 3, and 5 encode the same isoform (1).
    Source sequence(s)
    BC093074, BQ640137, BU685681
    Consensus CDS
    CCDS8496.1
    UniProtKB/Swiss-Prot
    Q9P016
    UniProtKB/TrEMBL
    A0A024R3M1
    Related
    ENSP00000376373.3, ENST00000392594.7
    Conserved Domains (1) summary
    pfam01878
    Location:55219
    EVE; EVE domain
  3. NM_014174.3NP_054893.1  thymocyte nuclear protein 1 isoform 1

    See identical proteins and their annotated locations for NP_054893.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Isoform 1 is also encoded by variants 3 and 5.
    Source sequence(s)
    AF161493, BQ959408
    Consensus CDS
    CCDS8496.1
    UniProtKB/Swiss-Prot
    Q9P016
    UniProtKB/TrEMBL
    A0A024R3M1
    Related
    ENSP00000341657.3, ENST00000341541.8
    Conserved Domains (1) summary
    pfam01878
    Location:55219
    EVE; EVE domain
  4. NM_199297.2NP_954994.1  thymocyte nuclear protein 1 isoform 2

    See identical proteins and their annotated locations for NP_954994.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an exon in the 3' coding region, compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, compared to isoform 1. Isoform 2 is also encoded by variant 4.
    Source sequence(s)
    AF182413, BC006978, BU658940
    Consensus CDS
    CCDS8497.1
    UniProtKB/Swiss-Prot
    Q9P016
    Related
    ENSP00000341452.5, ENST00000352327.5
    Conserved Domains (1) summary
    cl00728
    Location:57160
    EVE; EVE domain
  5. NM_199298.2NP_954995.1  thymocyte nuclear protein 1 isoform 1

    See identical proteins and their annotated locations for NP_954995.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 3, and 5 encode the same isoform (1).
    Source sequence(s)
    AF161493, BU658940
    Consensus CDS
    CCDS8496.1
    UniProtKB/Swiss-Prot
    Q9P016
    UniProtKB/TrEMBL
    A0A024R3M1
    Related
    ENSP00000376374.2, ENST00000392595.6
    Conserved Domains (1) summary
    pfam01878
    Location:55219
    EVE; EVE domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    134248265..134253407 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271527.4XP_005271584.1  thymocyte nuclear protein 1 isoform X1

    Conserved Domains (1) summary
    pfam01878
    Location:96260
    EVE; EVE domain
  2. XM_005271528.3XP_005271585.1  thymocyte nuclear protein 1 isoform X2

    Conserved Domains (1) summary
    cl00728
    Location:98201
    EVE; EVE domain
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