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PHPT1 phosphohistidine phosphatase 1 [ Homo sapiens (human) ]

Gene ID: 29085, updated on 24-Nov-2020

Summary

Official Symbol
PHPT1provided by HGNC
Official Full Name
phosphohistidine phosphatase 1provided by HGNC
Primary source
HGNC:HGNC:30033
See related
Ensembl:ENSG00000054148 MIM:610167
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PHP; PHP14; CGI-202; HSPC141; HEL-S-132P
Summary
This gene encodes an enzyme that catalyzes the reversible dephosphorylation of histidine residues in proteins. It may be involved in the dephosphorylation of G-beta and ATP citrate lyase and in negatively regulating CD4 T lymphocytes by dephosphorylation and inhibition of KCa3.1 channels. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Expression
Ubiquitous expression in heart (RPKM 26.6), prostate (RPKM 24.5) and 25 other tissues See more
Orthologs

Genomic context

See PHPT1 in Genome Data Viewer
Location:
9q34.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (136849409..136851024)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (139743256..139745490)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene RAB, member RAS oncogene family like 6 Neighboring gene microRNA 4292 Neighboring gene apical junction component 1 homolog Neighboring gene MAM domain containing 4 Neighboring gene endothelial differentiation related factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: MAMDC4

Homology

Clone Names

  • bA216L13.10, DKFZp564M173, 1700008C22Rik, RP11-216L13.10

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium channel inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
ion channel binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein histidine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein histidine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein histidine phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
14 kDa phosphohistidine phosphatase
Names
epididymis secretory sperm binding protein Li 132P
protein histidine phosphatase
protein janus-A homolog
sex-regulated protein janus-a
NP_001129333.1
NP_001274271.1
NP_001274272.1
NP_054891.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135861.3NP_001129333.1  14 kDa phosphohistidine phosphatase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL355987
    Consensus CDS
    CCDS48060.1
    UniProtKB/Swiss-Prot
    Q9NRX4
    Related
    ENSP00000360724.1, ENST00000371661.5
    Conserved Domains (1) summary
    pfam05005
    Location:995
    Ocnus; Janus/Ocnus family (Ocnus)
  2. NM_001287342.2NP_001274271.1  14 kDa phosphohistidine phosphatase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL355987
    Conserved Domains (1) summary
    pfam05005
    Location:9116
    Ocnus; Janus/Ocnus family (Ocnus)
  3. NM_001287343.2NP_001274272.1  14 kDa phosphohistidine phosphatase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL355987
    Related
    ENST00000462205.5
    Conserved Domains (1) summary
    pfam05005
    Location:996
    Ocnus; Janus/Ocnus family (Ocnus)
  4. NM_014172.6NP_054891.2  14 kDa phosphohistidine phosphatase isoform 3

    See identical proteins and their annotated locations for NP_054891.2

    Status: VALIDATED

    Source sequence(s)
    AL355987
    Consensus CDS
    CCDS7009.1
    UniProtKB/Swiss-Prot
    Q9NRX4
    UniProtKB/TrEMBL
    V9HWC4
    Related
    ENSP00000247665.10, ENST00000247665.12
    Conserved Domains (1) summary
    pfam05005
    Location:9114
    Ocnus; Janus/Ocnus family (Ocnus)

RNA

  1. NR_109807.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL355987
  2. NR_109808.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL355987

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    136849409..136851024
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001135860.1: Suppressed sequence

    Description
    NM_001135860.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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