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METTL5 methyltransferase 5, N6-adenosine [ Homo sapiens (human) ]

Gene ID: 29081, updated on 2-Oct-2021

Summary

Official Symbol
METTL5provided by HGNC
Official Full Name
methyltransferase 5, N6-adenosineprovided by HGNC
Primary source
HGNC:HGNC:25006
See related
Ensembl:ENSG00000138382 MIM:618628
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRT72; HSPC133
Expression
Ubiquitous expression in fat (RPKM 27.8), thyroid (RPKM 17.4) and 25 other tissues See more
Orthologs
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Genomic context

See METTL5 in Genome Data Viewer
Location:
2q31.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (169811757..169824905, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (170668267..170681415, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene patched domain containing 3 pseudogene 2 Neighboring gene cytochrome b5 type A pseudogene 2 Neighboring gene small RNA binding exonuclease protection factor La Neighboring gene small nucleolar RNA, C/D box 3K Neighboring gene ubiquitin protein ligase E3 component n-recognin 3 Neighboring gene VISTA enhancer hs1867 Neighboring gene NSA2 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10459

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables S-adenosyl-L-methionine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables rRNA (adenine-N6-)-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rRNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in stem cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
rRNA N6-adenosine-methyltransferase METTL5
Names
methyltransferase like 5
methyltransferase-like protein 5
NP_001280115.1
NP_001280116.1
NP_054887.2
XP_011509325.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293186.2NP_001280115.1  rRNA N6-adenosine-methyltransferase METTL5

    See identical proteins and their annotated locations for NP_001280115.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AF201938, CA337169
    Consensus CDS
    CCDS33320.1
    UniProtKB/Swiss-Prot
    Q9NRN9
    Related
    ENSP00000386582.1, ENST00000409965.5
    Conserved Domains (1) summary
    COG2263
    Location:7209
    COG2263; Predicted RNA methylase [General function prediction only]
  2. NM_001293187.2NP_001280116.1  rRNA N6-adenosine-methyltransferase METTL5

    See identical proteins and their annotated locations for NP_001280116.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AF201938, BC093014
    Consensus CDS
    CCDS33320.1
    UniProtKB/Swiss-Prot
    Q9NRN9
    Related
    ENSP00000376415.2, ENST00000392640.6
    Conserved Domains (1) summary
    COG2263
    Location:7209
    COG2263; Predicted RNA methylase [General function prediction only]
  3. NM_014168.4NP_054887.2  rRNA N6-adenosine-methyltransferase METTL5

    See identical proteins and their annotated locations for NP_054887.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AL523293, BC000921, CA337169
    Consensus CDS
    CCDS33320.1
    UniProtKB/Swiss-Prot
    Q9NRN9
    Related
    ENSP00000260953.5, ENST00000260953.10
    Conserved Domains (1) summary
    COG2263
    Location:7209
    COG2263; Predicted RNA methylase [General function prediction only]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    169811757..169824905 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511023.1XP_011509325.1  rRNA N6-adenosine-methyltransferase METTL5 isoform X1

    See identical proteins and their annotated locations for XP_011509325.1

    Related
    ENSP00000307903.3, ENST00000308099.7
    Conserved Domains (1) summary
    COG2263
    Location:7163
    COG2263; Predicted RNA methylase [General function prediction only]
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