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Wrn Werner syndrome RecQ like helicase [ Rattus norvegicus (Norway rat) ]

Gene ID: 290805, updated on 14-Mar-2017
Official Symbol
Wrnprovided by RGD
Official Full Name
Werner syndrome RecQ like helicaseprovided by RGD
Primary source
RGD:1564788
See related
Ensembl:ENSRNOG00000015440
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564788
Orthologs
Location:
16q12.3
Exon count:
34
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (62483773..62619018)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 16 NC_005115.3 (62148560..62283748)

Chromosome 16 - NC_005115.4Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S15a pseudogene Neighboring gene uncharacterized LOC102554887 Neighboring gene purine-rich element binding protein G Neighboring gene uncharacterized LOC108348406 Neighboring gene similar to ribosomal protein S15a Neighboring gene similar to ATP synthase mitochondrial F1 complex assembly factor 2

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
3'-5' DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
3'-5' exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
3'-5' exonuclease activity ISO
Inferred from Sequence Orthology
more info
 
3'-flap-structured DNA binding IEA
Inferred from Electronic Annotation
more info
 
3'-flap-structured DNA binding ISO
Inferred from Sequence Orthology
more info
 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP-dependent 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
ATP-dependent DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
ATPase activity ISO
Inferred from Sequence Orthology
more info
 
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
DNA helicase activity ISO
Inferred from Sequence Orthology
more info
 
G-quadruplex DNA binding IEA
Inferred from Electronic Annotation
more info
 
G-quadruplex DNA binding ISO
Inferred from Sequence Orthology
more info
 
Y-form DNA binding IEA
Inferred from Electronic Annotation
more info
 
Y-form DNA binding ISO
Inferred from Sequence Orthology
more info
 
bubble DNA binding IEA
Inferred from Electronic Annotation
more info
 
bubble DNA binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
exonuclease activity ISO
Inferred from Sequence Orthology
more info
 
forked DNA-dependent helicase activity IEA
Inferred from Electronic Annotation
more info
 
forked DNA-dependent helicase activity ISO
Inferred from Sequence Orthology
more info
 
four-way junction DNA binding IEA
Inferred from Electronic Annotation
more info
 
four-way junction DNA binding ISO
Inferred from Sequence Orthology
more info
 
four-way junction helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
four-way junction helicase activity ISO
Inferred from Sequence Orthology
more info
 
helicase activity ISO
Inferred from Sequence Orthology
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
manganese ion binding IEA
Inferred from Electronic Annotation
more info
 
manganese ion binding ISO
Inferred from Sequence Orthology
more info
 
oxidized purine DNA binding IEA
Inferred from Electronic Annotation
more info
 
oxidized purine DNA binding ISO
Inferred from Sequence Orthology
more info
 
protein complex binding IEA
Inferred from Electronic Annotation
more info
 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
telomeric D-loop binding IEA
Inferred from Electronic Annotation
more info
 
telomeric D-loop binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA duplex unwinding IBA
Inferred from Biological aspect of Ancestor
more info
 
DNA duplex unwinding ISO
Inferred from Sequence Orthology
more info
 
DNA metabolic process ISO
Inferred from Sequence Orthology
more info
 
DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
 
DNA replication ISO
Inferred from Sequence Orthology
more info
 
DNA synthesis involved in DNA repair IEA
Inferred from Electronic Annotation
more info
 
DNA synthesis involved in DNA repair ISO
Inferred from Sequence Orthology
more info
 
G-quadruplex DNA unwinding IEA
Inferred from Electronic Annotation
more info
 
G-quadruplex DNA unwinding ISO
Inferred from Sequence Orthology
more info
 
base-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
 
base-excision repair ISO
Inferred from Sequence Orthology
more info
 
brain development IEP
Inferred from Expression Pattern
more info
PubMed 
cell aging ISO
Inferred from Sequence Orthology
more info
 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to gamma radiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
cellular response to starvation IEA
Inferred from Electronic Annotation
more info
 
cellular response to starvation ISO
Inferred from Sequence Orthology
more info
 
double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
 
multicellular organism aging IEA
Inferred from Electronic Annotation
more info
 
multicellular organism aging ISO
Inferred from Sequence Orthology
more info
 
nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
nucleolus to nucleoplasm transport IEA
Inferred from Electronic Annotation
more info
 
nucleolus to nucleoplasm transport ISO
Inferred from Sequence Orthology
more info
 
positive regulation of hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of strand invasion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of strand invasion ISO
Inferred from Sequence Orthology
more info
 
regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
regulation of growth rate IEA
Inferred from Electronic Annotation
more info
 
regulation of growth rate ISO
Inferred from Sequence Orthology
more info
 
replication fork processing IEA
Inferred from Electronic Annotation
more info
 
replication fork processing ISO
Inferred from Sequence Orthology
more info
 
replicative cell aging IEA
Inferred from Electronic Annotation
more info
 
replicative cell aging ISO
Inferred from Sequence Orthology
more info
 
response to UV-C IEA
Inferred from Electronic Annotation
more info
 
response to UV-C ISO
Inferred from Sequence Orthology
more info
 
response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
telomere maintenance ISO
Inferred from Sequence Orthology
more info
 
telomeric D-loop disassembly IEA
Inferred from Electronic Annotation
more info
 
telomeric D-loop disassembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
MutLalpha complex IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with MutLalpha complex ISO
Inferred from Sequence Orthology
more info
 
centrosome IEA
Inferred from Electronic Annotation
more info
 
centrosome ISO
Inferred from Sequence Orthology
more info
 
chromosome IBA
Inferred from Biological aspect of Ancestor
more info
 
chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nuclear speck ISO
Inferred from Sequence Orthology
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
NOT nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
replication fork IEA
Inferred from Electronic Annotation
more info
 
replication fork ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
Werner syndrome ATP-dependent helicase; similar to Werner syndrome helicase homolog
Names
Werner syndrome, RecQ helicase-like

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005115.4 Reference Rnor_6.0 Primary Assembly

    Range
    62483773..62619018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253256.3XP_006253318.1  Werner syndrome ATP-dependent helicase isoform X2

    See identical proteins and their annotated locations for XP_006253318.1

    UniProtKB/TrEMBL
    F1LTH9
    Related
    ENSRNOP00000055596, ENSRNOT00000058805
    Conserved Domains (8) summary
    smart00341
    Location:11181194
    HRDC; Helicase and RNase D C-terminal
    TIGR00614
    Location:502975
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    cd06129
    Location:55223
    RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
    smart00956
    Location:9231016
    RQC; This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure
    cd00079
    Location:730832
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00270
    Location:515676
    DEAD; DEAD/DEAH box helicase
    pfam14493
    Location:12261316
    HTH_40; Helix-turn-helix domain
    pfam16124
    Location:837904
    RecQ_Zn_bind; RecQ zinc-binding
  2. XM_017600374.1XP_017455863.1  Werner syndrome ATP-dependent helicase isoform X1

Alternate Rn_Celera

Genomic

  1. AC_000084.1 Alternate Rn_Celera

    Range
    56796927..56929877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006222257.3XP_006222319.1  Werner syndrome ATP-dependent helicase isoform X2

    See identical proteins and their annotated locations for XP_006222319.1

    UniProtKB/TrEMBL
    F1LTH9
    Conserved Domains (8) summary
    smart00341
    Location:11181194
    HRDC; Helicase and RNase D C-terminal
    TIGR00614
    Location:502975
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    cd06129
    Location:55223
    RNaseD_like; DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins
    smart00956
    Location:9231016
    RQC; This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure
    cd00079
    Location:730832
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00270
    Location:515676
    DEAD; DEAD/DEAH box helicase
    pfam14493
    Location:12261316
    HTH_40; Helix-turn-helix domain
    pfam16124
    Location:837904
    RecQ_Zn_bind; RecQ zinc-binding
  2. XM_017587589.1XP_017443078.1  Werner syndrome ATP-dependent helicase isoform X1

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