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CCDC59 coiled-coil domain containing 59 [ Homo sapiens (human) ]

Gene ID: 29080, updated on 22-Aug-2020

Summary

Official Symbol
CCDC59provided by HGNC
Official Full Name
coiled-coil domain containing 59provided by HGNC
Primary source
HGNC:HGNC:25005
See related
Ensembl:ENSG00000133773
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BR22; TAP26; HSPC128
Expression
Ubiquitous expression in bone marrow (RPKM 20.9), testis (RPKM 10.5) and 25 other tissues See more
Orthologs

Genomic context

See CCDC59 in Genome Data Viewer
Location:
12q21.31
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (82352303..82358805, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (82746083..82752584, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2426 Neighboring gene uncharacterized LOC105369873 Neighboring gene methyltransferase like 25 Neighboring gene hepatitis A virus cellular receptor 1 pseudogene Neighboring gene uncharacterized LOC107987180

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide association analyses identify variants in developmental genes associated with hypospadias.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10294, DKFZp686K1021

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
thyroid transcription factor 1-associated protein 26
Names
TTF-1-associated protein 26
TTF-1-associated protein BR2
coiled-coil domain-containing protein 59

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014167.5NP_054886.2  thyroid transcription factor 1-associated protein 26

    See identical proteins and their annotated locations for NP_054886.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AC083811, BC020647, BG538660
    Consensus CDS
    CCDS9023.1
    UniProtKB/Swiss-Prot
    Q9P031
    Related
    ENSP00000256151.7, ENST00000256151.8
    Conserved Domains (1) summary
    pfam08524
    Location:160238
    rRNA_processing; rRNA processing

RNA

  1. NR_033192.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC083811, BM846580, DA666239

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    82352303..82358805 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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