U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NR3C1 nuclear receptor subfamily 3 group C member 1 [ Homo sapiens (human) ]

Gene ID: 2908, updated on 19-Sep-2024

Summary

Official Symbol
NR3C1provided by HGNC
Official Full Name
nuclear receptor subfamily 3 group C member 1provided by HGNC
Primary source
HGNC:HGNC:7978
See related
Ensembl:ENSG00000113580 MIM:138040; AllianceGenome:HGNC:7978
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GR; GCR; GRL; GCCR; GCRST
Summary
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in fat (RPKM 11.8), lung (RPKM 9.9) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See NR3C1 in Genome Data Viewer
Location:
5q31.3
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (143277931..143435512, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (143809293..143966896, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (142657496..142815077, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 26 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142593978-142594526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:142594527-142595075 Neighboring gene uncharacterized LOC124901099 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23335 Neighboring gene uncharacterized LOC124901100 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23336 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23337 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23338 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23339 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23340 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23341 Neighboring gene ribosomal protein L7 pseudogene 21 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16480 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16481 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16482 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16483 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:142784152-142784919 Neighboring gene uncharacterized LOC128966704 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:142784920-142785686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23347 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16484 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23348 Neighboring gene Sharpr-MPRA regulatory region 10277 Neighboring gene uncharacterized LOC105378208 Neighboring gene uncharacterized LOC105378209 Neighboring gene RNA, U7 small nuclear 156 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23349 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:142974806-142976005

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Glucocorticoid resistance
MedGen: C1841972 OMIM: 615962 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
EBI GWAS Catalog
Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr Glucocorticoid receptor (GR) agonists, dexamethasone (Dex) and medroxyprogesterone acetate (MPA), enhance HIV-1 Vpr peptide (amino acids 52-96)-mediated apoptosis of CD4+ T-cells in a GR-dependent manner PubMed
vpr HIV-1 Vpr leucine residues mediate Vpr-Glucocorticoid Receptor (GR) interaction and promoter transactivation; mutation at residue L22 results in 8- to 11-fold higher GRE and HIV-1 LTR transactivation, while L42 and L67 mutants showed reduced activation PubMed
vpr HIV-1 Vpr activates transcription of glucocorticoid-responsive promoters by binding directly to p300/CBP co-activators, forming a stable complex with p300 and interacting with ligand-bound glucocorticoid receptor PubMed
vpr HIV-1 Vpr potentiates the trans-activation, but not the trans-repression, properties of the glucocorticoid receptor on NF-kappa B and activating protein 1-regulated simple promoters PubMed
vpr HIV-1 Vpr (amino acids 22-26 and 64-68) binds to and activates glucocorticoid receptor (GR) and transactivates the HIV-1 LTR promoter through the host GR pathway PubMed
vpr HIV-1 Vpr targets the glucocorticoid receptor type II complex through an interaction with Vpr interacting protein 1 (Rip-1), a 41 kDa cytosolic protein that binds to Vpr and in a complex with the human glucocorticoid receptor PubMed
vpr HIV-1 Vpr affects the gene expression of glucocorticoid-regulated genes (IL-12, CD44, Toll-like receptor 4 and indolamine 2,3-dioxygenase, macrophage receptor with collagenous structure, and thrombospondin 1) through activation of the GR pathway PubMed
vpr Studies suggest effects of HIV-1 Vpr on cytokine expression (IL-2, IL-10, IL-12, TNFalpha and IL-4) and T-cell proliferation may be mediated through activation of the glucocorticoid receptor pathway PubMed
vpr Interaction of HIV-1 Vpr and hVIP/mov34 may be involved in the activation of glucocorticoid receptor by Vpr PubMed
vpr Transcription factors TFIIH, CDK7, Cyclin H, and MAT1 enhance HIV-1 Vpr activation of glucocorticoid receptor PubMed
vpr HIV-1 Vpr synergistically enhances SRC-1 ligand-activated glucocorticoid receptor activity PubMed
vpr HIV-1 Vpr (amino acids 1-35) binds to TFIID, an interaction that is associated with the ability of Vpr to stimulate transcription through the glucocorticoid receptor pathway PubMed
vpr Specific binding of HIV-1 Vpr (amino acids 15-35) to TFIIB (amino acids 52-55) causes a conformational change in TFIIB and is correlated with the ability of Vpr to stimulate transcription through the glucocorticoid receptor pathway PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables Hsp90 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables TBP-class protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables estrogen response element binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear glucocorticoid receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables steroid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables steroid hormone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in adrenal gland development IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in astrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to dexamethasone stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to glucocorticoid stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to steroid hormone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to transforming growth factor beta stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
 
involved_in gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in glucocorticoid mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in glucocorticoid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in mammary gland duct morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in maternal behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in microglia differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in motor behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuroinflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in nuclear receptor-mediated glucocorticoid signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in nuclear receptor-mediated steroid hormone signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of miRNA transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of glucocorticoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IC
Inferred by Curator
more info
PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle IEA
Inferred from Electronic Annotation
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
glucocorticoid receptor
Names
nuclear receptor subfamily 3 group C member 1 variant hGR-B(54)
nuclear receptor subfamily 3 group C member 1 variant hGR-B(77)
nuclear receptor subfamily 3 group C member 1 variant hGR-B(93)
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009062.1 RefSeqGene

    Range
    36827..162579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000176.3NP_000167.1  glucocorticoid receptor isoform alpha

    See identical proteins and their annotated locations for NP_000167.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes the predominant physiological isoform (alpha, also known as GRalpha or GR-A). Variants 1-5 encode the same isoform.
    Source sequence(s)
    AC004782, AC091925, X03225
    Consensus CDS
    CCDS4278.1
    UniProtKB/Swiss-Prot
    A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4
    UniProtKB/TrEMBL
    A0A5B9RIM3, F1D8N4
    Related
    ENSP00000377977.2, ENST00000394464.7
    Conserved Domains (3) summary
    cd07076
    Location:531777
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:417494
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:26401
    GCR; Glucocorticoid receptor
  2. NM_001018074.1NP_001018084.1  glucocorticoid receptor isoform alpha

    See identical proteins and their annotated locations for NP_001018084.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternative 5' terminal non-coding exon, thus has a different 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (alpha).
    Source sequence(s)
    AC004782, AC091925, X03225
    Consensus CDS
    CCDS4278.1
    UniProtKB/Swiss-Prot
    A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4
    UniProtKB/TrEMBL
    A0A5B9RIM3, F1D8N4
    Conserved Domains (3) summary
    cd07076
    Location:531777
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:417494
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:26401
    GCR; Glucocorticoid receptor
  3. NM_001018075.1NP_001018085.1  glucocorticoid receptor isoform alpha

    See identical proteins and their annotated locations for NP_001018085.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternative 5' terminal non-coding exon, thus has a different 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (alpha)
    Source sequence(s)
    AC004782, AC091925, X03225
    Consensus CDS
    CCDS4278.1
    UniProtKB/Swiss-Prot
    A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4
    UniProtKB/TrEMBL
    A0A5B9RIM3, F1D8N4
    Conserved Domains (3) summary
    cd07076
    Location:531777
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:417494
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:26401
    GCR; Glucocorticoid receptor
  4. NM_001018076.2NP_001018086.1  glucocorticoid receptor isoform alpha

    See identical proteins and their annotated locations for NP_001018086.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternative 5' terminal non-coding exon, thus has a different 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (alpha).
    Source sequence(s)
    AC004782, AC091925, BF966114, X03225
    Consensus CDS
    CCDS4278.1
    UniProtKB/Swiss-Prot
    A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4
    UniProtKB/TrEMBL
    A0A5B9RIM3, F1D8N4
    Related
    ENSP00000427672.1, ENST00000503201.1
    Conserved Domains (3) summary
    cd07076
    Location:531777
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:417494
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:26401
    GCR; Glucocorticoid receptor
  5. NM_001018077.1NP_001018087.1  glucocorticoid receptor isoform alpha

    See identical proteins and their annotated locations for NP_001018087.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternative 5' terminal non-coding exon, thus has a different 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (alpha).
    Source sequence(s)
    AC004782, AC091925, X03225
    Consensus CDS
    CCDS4278.1
    UniProtKB/Swiss-Prot
    A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4
    UniProtKB/TrEMBL
    A0A5B9RIM3, F1D8N4
    Related
    ENSP00000343205.2, ENST00000343796.6
    Conserved Domains (3) summary
    cd07076
    Location:531777
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:417494
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:26401
    GCR; Glucocorticoid receptor
  6. NM_001020825.2NP_001018661.1  glucocorticoid receptor isoform beta

    See identical proteins and their annotated locations for NP_001018661.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in a frame-shift and a shorter isoform (beta, also known as GRbeta) with a distinct C-terminus compared to isoform alpha. This isoform resides primarily in the nucleus, lacks hormone-binding activity, and has a dominant negative effect on the action of isoform alpha (PMID:8621628).
    Source sequence(s)
    AC004782, AC091925, X03348
    Consensus CDS
    CCDS47298.1
    UniProtKB/TrEMBL
    E5KQF5, H6V745
    Related
    ENSP00000387672.2, ENST00000415690.6
    Conserved Domains (3) summary
    cd07172
    Location:417494
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:26401
    GCR; Glucocorticoid receptor
    cl11397
    Location:531729
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  7. NM_001024094.2NP_001019265.1  glucocorticoid receptor isoform gamma

    See identical proteins and their annotated locations for NP_001019265.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate in-frame donor splice site at one of the coding exons compared to variant 1. This results in an isoform (gamma) that is 1 aa longer than isoform alpha. The insertion of an additional amino acid (arginine) in the DNA binding domain has been reported to decrease transcriptional activation by the glucocorticoid receptor (PMID:10566686).
    Source sequence(s)
    AC004782, AC091925, U01351
    Consensus CDS
    CCDS34258.1
    UniProtKB/TrEMBL
    A0A5B9RIM3, E5KQF6
    Related
    ENSP00000231509.3, ENST00000231509.7
    Conserved Domains (3) summary
    cd07076
    Location:532778
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:417495
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:26401
    GCR; Glucocorticoid receptor
  8. NM_001204258.2NP_001191187.1  glucocorticoid receptor isoform alpha-B

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-B, also known as GR-B) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 571-573).
    Source sequence(s)
    AC004782, AC091925, CA425706, U01351, X03225
    UniProtKB/TrEMBL
    A0A5B9RIM3
    Conserved Domains (3) summary
    cd07076
    Location:505751
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:391468
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:1375
    GCR; Glucocorticoid receptor
  9. NM_001204259.2NP_001191188.1  glucocorticoid receptor isoform alpha-C1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-C1, also known as GR-C1) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 748-750).
    Source sequence(s)
    AC004782, AC091925, CA425706, U01351, X03225
    UniProtKB/TrEMBL
    A0A5B9RIM3
    Conserved Domains (3) summary
    cd07076
    Location:446692
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:332409
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:1316
    GCR; Glucocorticoid receptor
  10. NM_001204260.2NP_001191189.1  glucocorticoid receptor isoform alpha-C2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-C2, also known as GR-C2) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 760-762).
    Source sequence(s)
    AC004782, AC091925, CA425706, U01351, X03225
    UniProtKB/TrEMBL
    A0A5B9RIM3
    Conserved Domains (3) summary
    cd07076
    Location:442688
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:328405
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:1312
    GCR; Glucocorticoid receptor
  11. NM_001204261.2NP_001191190.1  glucocorticoid receptor isoform alpha-C3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternative in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-C3, also known as GR-C3) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 784-786).
    Source sequence(s)
    AC004782, AC091925, CA425706, U01351, X03225
    UniProtKB/TrEMBL
    A0A5B9RIM3
    Conserved Domains (3) summary
    cd07076
    Location:434680
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:320397
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:1304
    GCR; Glucocorticoid receptor
  12. NM_001204262.2NP_001191191.1  glucocorticoid receptor isoform alpha-D1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-D1, also known as GR-D1) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 1438-1440).
    Source sequence(s)
    AC004782, AC091925, CA425706, U01351, X03225
    UniProtKB/TrEMBL
    B7Z7I2
    Conserved Domains (3) summary
    cd07076
    Location:216462
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:102179
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:186
    GCR; Glucocorticoid receptor
  13. NM_001204263.2NP_001191192.1  glucocorticoid receptor isoform alpha-D2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-D2, also known as GR-D2) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 1483-1485).
    Source sequence(s)
    AC004782, AC091925, CA425706, U01351, X03225
    UniProtKB/TrEMBL
    B7Z7I2
    Conserved Domains (3) summary
    cd07076
    Location:201447
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:87164
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:171
    GCR; Glucocorticoid receptor
  14. NM_001204264.2NP_001191193.1  glucocorticoid receptor isoform alpha-D3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-D3, also known as GR-D3) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 1498-1500).
    Source sequence(s)
    AC004782, AC091925, CA425706, U01351, X03225
    UniProtKB/TrEMBL
    B7Z7I2
    Conserved Domains (3) summary
    cd07076
    Location:196442
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:82159
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:166
    GCR; Glucocorticoid receptor
  15. NM_001204265.2NP_001191194.1  glucocorticoid receptor isoform GR-P

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8, also known as GR-P) is missing 2 exons from the 3' end, and has a different 3' end compared to variant 1. This results in an isoform (GR-P) with a shorter and unique C-terminus compared to isoform alpha. The function of the encoded protein is not known, however, this variant is highly expressed in cells that are resistant to glucocorticoids, and may act to modulate glucocorticoid responsiveness (PMIDs:7796394, 11358809).
    Source sequence(s)
    AA737284, AC091925, BF244382, U01351, U25029
    UniProtKB/TrEMBL
    F5ATB8
    Conserved Domains (3) summary
    cd07172
    Location:417494
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:26401
    GCR; Glucocorticoid receptor
    cl11397
    Location:531674
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  16. NM_001364180.2NP_001351109.1  glucocorticoid receptor isoform alpha

    Status: REVIEWED

    Source sequence(s)
    AC004782, AC091925
    Consensus CDS
    CCDS4278.1
    UniProtKB/Swiss-Prot
    A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4
    UniProtKB/TrEMBL
    A0A5B9RIM3, F1D8N4
    Conserved Domains (3) summary
    cd07076
    Location:531777
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:417494
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:26401
    GCR; Glucocorticoid receptor
  17. NM_001364181.2NP_001351110.1  glucocorticoid receptor isoform alpha

    Status: REVIEWED

    Source sequence(s)
    AC004782, AC091925
    Consensus CDS
    CCDS4278.1
    UniProtKB/Swiss-Prot
    A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4
    UniProtKB/TrEMBL
    A0A5B9RIM3, F1D8N4
    Conserved Domains (3) summary
    cd07076
    Location:531777
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:417494
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:26401
    GCR; Glucocorticoid receptor
  18. NM_001364182.1NP_001351111.1  glucocorticoid receptor isoform alpha

    Status: REVIEWED

    Source sequence(s)
    AC004782, AC091925
    Consensus CDS
    CCDS4278.1
    UniProtKB/Swiss-Prot
    A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4
    UniProtKB/TrEMBL
    A0A5B9RIM3, F1D8N4
    Conserved Domains (3) summary
    cd07076
    Location:531777
    NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily
    cd07172
    Location:417494
    NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    pfam02155
    Location:26401
    GCR; Glucocorticoid receptor
  19. NM_001364183.2NP_001351112.1  glucocorticoid receptor isoform gamma

    Status: REVIEWED

    Source sequence(s)
    AC004782, AC091925, BX648553
    Consensus CDS
    CCDS34258.1
    UniProtKB/TrEMBL
    A0A5B9RIM3, E5KQF6
    Related
    ENSP00000422518.1, ENST00000504572.5
  20. NM_001364184.2NP_001351113.1  glucocorticoid receptor isoform gamma

    Status: REVIEWED

    Source sequence(s)
    AC004782, AC091925
    Consensus CDS
    CCDS34258.1
    UniProtKB/TrEMBL
    A0A5B9RIM3, E5KQF6
    Related
    ENSP00000377979.2, ENST00000394466.6
  21. NM_001364185.1NP_001351114.1  glucocorticoid receptor isoform gamma

    Status: REVIEWED

    Source sequence(s)
    AC004782, AC091925
    Consensus CDS
    CCDS34258.1
    UniProtKB/TrEMBL
    A0A5B9RIM3, E5KQF6

RNA

  1. NR_157096.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004782, AC091925, AK302050

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    143277931..143435512 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    143809293..143966896 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)