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Atp13a1 ATPase 13A1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 290673, updated on 5-Sep-2025
Official Symbol
Atp13a1provided by RGD
Official Full Name
ATPase 13A1provided by RGD
Primary source
RGD:1306033
See related
Ensembl:ENSRNOG00000010776 AllianceGenome:RGD:1306033
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Atp13a
Summary
Predicted to enable ATPase-coupled monoatomic cation transmembrane transporter activity; P-type ion transporter activity; and membrane protein dislocase activity. Predicted to be involved in extraction of mislocalized protein from ER membrane; intracellular calcium ion homeostasis; and transmembrane transport. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human ATP13A1 (ATPase 13A1). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Spleen (RPKM 134.5), Thymus (RPKM 127.7) and 9 other tissues See more
Orthologs
human mouse all
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See Atp13a1 in Genome Data Viewer
Location:
16p14
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (19649065..19665126, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (19615156..19631546, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (21364087..21380142, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene lysophosphatidic acid receptor 2 Neighboring gene Gem-interacting protein Neighboring gene zinc finger protein 709-like Neighboring gene U4 spliceosomal RNA Neighboring gene zinc finger protein 866

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. The identification of genes specifically expressed in epithelial cells of the rat intestinal crypts. Sykes DE, et al. Differentiation, 1992 May. PMID 1639225
  2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled monoatomic cation transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables P-type ion transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables P-type transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables membrane protein dislocase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables membrane protein dislocase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in extraction of mislocalized protein from ER membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in extraction of mislocalized protein from ER membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
endoplasmic reticulum transmembrane helix translocase
Names
ATPase type 13A1
manganese-transporting ATPase 13A1
probable cation-transporting ATPase 13A1
NP_001099549.2
XP_038950273.1
XP_038950274.1
XP_038950275.1
XP_063131279.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106079.2 → NP_001099549.2  endoplasmic reticulum transmembrane helix translocase

    See identical proteins and their annotated locations for NP_001099549.2

    Status: VALIDATED

    Source sequence(s)
    BC091262, CA340650, CB691511, CK601062, CO573028
    UniProtKB/TrEMBL
    A6KAB6, B5DEX7, G3V7I3
    Related
    ENSRNOP00000015247.3, ENSRNOT00000015247.7
    Conserved Domains (5) summary
    COG4087
    Location:825 → 878
    COG4087; Soluble P-type ATPase [General function prediction only]
    TIGR01657
    Location:79 → 1166
    P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
    pfam00122
    Location:292 → 504
    E1-E2_ATPase; E1-E2 ATPase
    pfam12710
    Location:637 → 867
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:578 → 661
    Cation_ATPase; Cation transport ATPase (P-type)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    19649065..19665126 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094345.2 → XP_038950273.1  endoplasmic reticulum transmembrane helix translocase isoform X1

    Conserved Domains (1) summary
    cl21460
    Location:27 → 737
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  2. XM_039094346.2 → XP_038950274.1  endoplasmic reticulum transmembrane helix translocase isoform X1

    Conserved Domains (1) summary
    cl21460
    Location:27 → 737
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  3. XM_039094347.2 → XP_038950275.1  endoplasmic reticulum transmembrane helix translocase isoform X2

    Conserved Domains (1) summary
    cl21460
    Location:1 → 556
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  4. XM_063275209.1 → XP_063131279.1  endoplasmic reticulum transmembrane helix translocase isoform X3

RNA

  1. XR_005494574.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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