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Gatad2a GATA zinc finger domain containing 2A [ Rattus norvegicus (Norway rat) ]

Gene ID: 290669, updated on 5-Sep-2025
Official Symbol
Gatad2aprovided by RGD
Official Full Name
GATA zinc finger domain containing 2Aprovided by RGD
Primary source
RGD:1310596
See related
Ensembl:ENSRNOG00000022173 AllianceGenome:RGD:1310596
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310596
Summary
Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in chromatin remodeling and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including blood vessel development; chordate embryonic development; and embryonic body morphogenesis. Predicted to be located in nucleoplasm. Predicted to be part of NuRD complex. Orthologous to human GATAD2A (GATA zinc finger domain containing 2A). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Thymus (RPKM 160.0), Adrenal (RPKM 152.8) and 9 other tissues See more
Orthologs
human mouse all
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See Gatad2a in Genome Data Viewer
Location:
16p14
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (19463500..19553497)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (19429578..19520320)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (21177793..21267768)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene SURP and G patch domain containing 1 Neighboring gene MAU2 sister chromatid cohesion factor Neighboring gene testis-specific serine kinase 6 Neighboring gene NADH:ubiquinone oxidoreductase subunit A13 Neighboring gene YjeF N-terminal domain containing 3

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Mutants in the mouse NuRD/Mi2 component P66alpha are embryonic lethal. Marino S, et al. PLoS One, 2007 Jun 13. PMID 17565372, Free PMC Article
  2. Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3. Brackertz M, et al. J Biol Chem, 2002 Oct 25. PMID 12183469
  3. The nucleosome remodeling and deacetylase complex in development and disease. Basta J, et al. Transl Res, 2015 Jan. PMID 24880148, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Clone Names

  • MGC109147

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within anterior neuropore closure ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within blood vessel development ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic body morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neural fold formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within programmed cell death ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of NuRD complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NuRD complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
transcriptional repressor p66-alpha
Names
p66 alpha

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013881.3 → NP_001013903.2  transcriptional repressor p66-alpha isoform 3

    See identical proteins and their annotated locations for NP_001013903.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A6KA99
    Related
    ENSRNOP00000027943.7, ENSRNOT00000027943.8
    Conserved Domains (2) summary
    pfam16563
    Location:133 → 169
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    cl00158
    Location:417 → 450
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

  2. NM_001436775.1 → NP_001423704.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016

  3. NM_001436776.1 → NP_001423705.1  transcriptional repressor p66-alpha isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016

  4. NM_001436777.1 → NP_001423706.1  transcriptional repressor p66-alpha isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    G3V8R7

  5. NM_001436778.1 → NP_001423707.1  transcriptional repressor p66-alpha isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    G3V8R7

  6. NM_001436779.1 → NP_001423708.1  transcriptional repressor p66-alpha isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    G3V8R7

  7. NM_001436780.1 → NP_001423709.1  transcriptional repressor p66-alpha isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    G3V8R7

  8. NM_001436781.1 → NP_001423710.1  transcriptional repressor p66-alpha isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A6KA99

  9. NM_001436782.1 → NP_001423711.1  transcriptional repressor p66-alpha isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A6KA99

  10. NM_001436783.1 → NP_001423712.1  transcriptional repressor p66-alpha isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016

  11. NM_001436784.1 → NP_001423713.1  transcriptional repressor p66-alpha isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016

  12. NM_001436785.1 → NP_001423714.1  transcriptional repressor p66-alpha isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016

  13. NM_001436786.1 → NP_001423715.1  transcriptional repressor p66-alpha isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016

  14. NM_001436787.1 → NP_001423716.1  transcriptional repressor p66-alpha isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016

  15. NM_001436788.1 → NP_001423717.1  transcriptional repressor p66-alpha isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016

  16. NM_001436789.1 → NP_001423718.1  transcriptional repressor p66-alpha isoform 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016

  17. NM_001436790.1 → NP_001423719.1  transcriptional repressor p66-alpha isoform 7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    19463500..19553497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275203.1 → XP_063131273.1  transcriptional repressor p66-alpha isoform X6

    Related
    ENSRNOP00000102915.1, ENSRNOT00000168140.1

  2. XM_017600035.3 → XP_017455524.1  transcriptional repressor p66-alpha isoform X2

    Conserved Domains (2) summary
    pfam16563
    Location:133 → 169
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    cl29608
    Location:420 → 453
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

  3. XM_063275204.1 → XP_063131274.1  transcriptional repressor p66-alpha isoform X6

  4. XM_063275194.1 → XP_063131264.1  transcriptional repressor p66-alpha isoform X3

  5. XM_063275205.1 → XP_063131275.1  transcriptional repressor p66-alpha isoform X7

  6. XM_063275199.1 → XP_063131269.1  transcriptional repressor p66-alpha isoform X4

  7. XM_039094339.2 → XP_038950267.1  transcriptional repressor p66-alpha isoform X2

    Conserved Domains (2) summary
    pfam16563
    Location:133 → 169
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    cl29608
    Location:420 → 453
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

  8. XM_063275197.1 → XP_063131267.1  transcriptional repressor p66-alpha isoform X3

  9. XM_063275207.1 → XP_063131277.1  transcriptional repressor p66-alpha isoform X8

  10. XM_063275202.1 → XP_063131272.1  transcriptional repressor p66-alpha isoform X5

  11. XM_063275200.1 → XP_063131270.1  transcriptional repressor p66-alpha isoform X5

  12. XM_063275192.1 → XP_063131262.1  transcriptional repressor p66-alpha isoform X2

  13. XM_017600034.3 → XP_017455523.1  transcriptional repressor p66-alpha isoform X2

    Conserved Domains (2) summary
    pfam16563
    Location:133 → 169
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    cl29608
    Location:420 → 453
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

  14. XM_039094341.2 → XP_038950269.1  transcriptional repressor p66-alpha isoform X3

    Conserved Domains (2) summary
    pfam16563
    Location:133 → 169
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    cl29608
    Location:419 → 452
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

  15. XM_039094342.2 → XP_038950270.1  transcriptional repressor p66-alpha isoform X5

    Conserved Domains (2) summary
    pfam16563
    Location:133 → 169
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    cl29608
    Location:416 → 449
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

  16. XM_006252887.4 → XP_006252949.1  transcriptional repressor p66-alpha isoform X2

    See identical proteins and their annotated locations for XP_006252949.1

    Conserved Domains (2) summary
    pfam16563
    Location:133 → 169
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    cl29608
    Location:420 → 453
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

  17. XM_039094340.2 → XP_038950268.1  transcriptional repressor p66-alpha isoform X2

    Conserved Domains (2) summary
    pfam16563
    Location:133 → 169
    P66_CC; Coiled-coil and interaction region of P66A and P66B with MBD2
    cl29608
    Location:420 → 453
    ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

  18. XM_063275195.1 → XP_063131265.1  transcriptional repressor p66-alpha isoform X3

    Related
    ENSRNOP00000101199.1, ENSRNOT00000162058.1

  19. XM_063275198.1 → XP_063131268.1  transcriptional repressor p66-alpha isoform X4

  20. XM_063275201.1 → XP_063131271.1  transcriptional repressor p66-alpha isoform X5

  21. XM_063275193.1 → XP_063131263.1  transcriptional repressor p66-alpha isoform X2

  22. XM_063275190.1 → XP_063131260.1  transcriptional repressor p66-alpha isoform X1

  23. XM_063275208.1 → XP_063131278.1  transcriptional repressor p66-alpha isoform X9

Nucleotide Protein Strain
Heading Accession and Version

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