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WDR91 WD repeat domain 91 [ Homo sapiens (human) ]

Gene ID: 29062, updated on 17-Sep-2024

Summary

Official Symbol
WDR91provided by HGNC
Official Full Name
WD repeat domain 91provided by HGNC
Primary source
HGNC:HGNC:24997
See related
Ensembl:ENSG00000105875 MIM:616303; AllianceGenome:HGNC:24997
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SORF1; SORF-1; HSPC049
Summary
Enables phosphatidylinositol 3-kinase regulator activity. Involved in early endosome to late endosome transport; regulation of cellular protein catabolic process; and regulation of phosphatidylinositol 3-kinase activity. Located in cytosol; early endosome membrane; and late endosome membrane. Is extrinsic component of endosome membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney (RPKM 8.1), placenta (RPKM 7.8) and 25 other tissues See more
Orthologs
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Genomic context

See WDR91 in Genome Data Viewer
Location:
7q33
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (135183839..135211526, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (136491701..136519383, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (134868591..134896278, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene AGBL carboxypeptidase 3 Neighboring gene cell cycle regulator of NHEJ Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26702 Neighboring gene RNF14 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26703 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26704 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26705 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26707 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18676 Neighboring gene transmembrane protein 140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26709 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26711 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:134877948-134879147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26712 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:134888580-134888794 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18677 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:134893611-134894810 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18678 Neighboring gene microRNA 6509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26713 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:134935285-134935435 Neighboring gene uncharacterized LOC107984123 Neighboring gene stimulated by retinoic acid 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26714 Neighboring gene solute carrier family 23 member 4, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of WD repeat domain 91 (WDR91; HSPC049) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatidylinositol 3-kinase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables phosphatidylinositol 3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in early endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in late endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
WD repeat-containing protein 91

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362736.2NP_001349665.1  WD repeat-containing protein 91 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009542, AC083862, BC017246
    UniProtKB/TrEMBL
    C9J1X0
    Conserved Domains (3) summary
    sd00039
    Location:505576
    7WD40; WD40 repeat [structural motif]
    pfam12881
    Location:253343
    NUT; NUT protein
    cl25539
    Location:407758
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001362737.2NP_001349666.1  WD repeat-containing protein 91 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC009542, AC083862, BC017246, BG767291
    UniProtKB/TrEMBL
    C9J1X0
    Conserved Domains (3) summary
    sd00039
    Location:454510
    7WD40; WD40 repeat [structural motif]
    pfam12881
    Location:253343
    NUT; NUT protein
    cl25539
    Location:407765
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_001362738.2NP_001349667.1  WD repeat-containing protein 91 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC009542, AC083862, BC017246, DA634150
    Conserved Domains (3) summary
    sd00039
    Location:243314
    7WD40; WD40 repeat [structural motif]
    pfam12881
    Location:9100
    NUT; NUT protein
    cl25539
    Location:164496
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. NM_014149.4NP_054868.3  WD repeat-containing protein 91 isoform 3

    See identical proteins and their annotated locations for NP_054868.3

    Status: VALIDATED

    Source sequence(s)
    AC009542, AC083862, BC017246
    Consensus CDS
    CCDS34758.1
    UniProtKB/Swiss-Prot
    A4D1P6, A6NK54, C9JMI4, Q6FI65, Q6MZQ1, Q6P4I1, Q96AE5, Q96G63, Q9H062, Q9H9B6, Q9NVG7, Q9NZY6
    UniProtKB/TrEMBL
    C9J1X0
    Related
    ENSP00000346466.4, ENST00000354475.5
    Conserved Domains (3) summary
    sd00039
    Location:486557
    7WD40; WD40 repeat [structural motif]
    pfam12881
    Location:253343
    NUT; NUT protein
    cl25539
    Location:407739
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. NR_156130.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009542, AC083862, AK022935
    Related
    ENST00000684339.1
  2. NR_156131.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009542, AC083862, BC017246, DA634150
    Related
    ENST00000684322.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    135183839..135211526 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420266.1XP_047276222.1  WD repeat-containing protein 91 isoform X1

    Related
    ENSP00000508083.1, ENST00000683947.1
  2. XM_047420267.1XP_047276223.1  WD repeat-containing protein 91 isoform X2

    UniProtKB/TrEMBL
    A0A804HI90
    Related
    ENSP00000506955.1, ENST00000682250.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    136491701..136519383 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357997.1XP_054213972.1  WD repeat-containing protein 91 isoform X1

  2. XM_054357998.1XP_054213973.1  WD repeat-containing protein 91 isoform X2

    UniProtKB/TrEMBL
    A0A804HI90