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WDR91 WD repeat domain 91 [ Homo sapiens (human) ]

Gene ID: 29062, updated on 4-Jul-2021

Summary

Official Symbol
WDR91provided by HGNC
Official Full Name
WD repeat domain 91provided by HGNC
Primary source
HGNC:HGNC:24997
See related
Ensembl:ENSG00000105875 MIM:616303
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SORF1; SORF-1; HSPC049
Expression
Ubiquitous expression in kidney (RPKM 8.1), placenta (RPKM 7.8) and 25 other tissues See more
Orthologs
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Genomic context

See WDR91 in Genome Data Viewer
Location:
7q33
Exon count:
17
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (135183839..135211556, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (134868591..134896278, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene AGBL carboxypeptidase 3 Neighboring gene cell cycle regulator of NHEJ Neighboring gene RNF14 pseudogene 4 Neighboring gene transmembrane protein 140 Neighboring gene microRNA 6509 Neighboring gene uncharacterized LOC107984123 Neighboring gene stimulated by retinoic acid 8 Neighboring gene solute carrier family 23 member 4, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of WD repeat domain 91 (WDR91; HSPC049) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatidylinositol 3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylinositol 3-kinase regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in early endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extrinsic component of endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extrinsic component of endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in late endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
WD repeat-containing protein 91

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362736.2NP_001349665.1  WD repeat-containing protein 91 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009542, AC083862, BC017246
    Conserved Domains (3) summary
    sd00039
    Location:505576
    7WD40; WD40 repeat [structural motif]
    pfam12881
    Location:253343
    NUT; NUT protein
    cl25539
    Location:407758
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001362737.2NP_001349666.1  WD repeat-containing protein 91 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC009542, AC083862, BC017246, BG767291
    Conserved Domains (3) summary
    sd00039
    Location:454510
    7WD40; WD40 repeat [structural motif]
    pfam12881
    Location:253343
    NUT; NUT protein
    cl25539
    Location:407765
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_001362738.2NP_001349667.1  WD repeat-containing protein 91 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC009542, AC083862, BC017246, DA634150
    Conserved Domains (3) summary
    sd00039
    Location:243314
    7WD40; WD40 repeat [structural motif]
    pfam12881
    Location:9100
    NUT; NUT protein
    cl25539
    Location:164496
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. NM_014149.4NP_054868.3  WD repeat-containing protein 91 isoform 3

    See identical proteins and their annotated locations for NP_054868.3

    Status: VALIDATED

    Source sequence(s)
    AC009542, AC083862, BC017246
    Consensus CDS
    CCDS34758.1
    UniProtKB/Swiss-Prot
    A4D1P6
    Related
    ENSP00000346466.4, ENST00000354475.5
    Conserved Domains (3) summary
    sd00039
    Location:486557
    7WD40; WD40 repeat [structural motif]
    pfam12881
    Location:253343
    NUT; NUT protein
    cl25539
    Location:407739
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. NR_156130.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009542, AC083862, AK022935
    Related
    ENST00000684339.1
  2. NR_156131.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC009542, AC083862, BC017246, DA634150
    Related
    ENST00000684322.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    135183839..135211556 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516083.3XP_011514385.1  WD repeat-containing protein 91 isoform X1

    Conserved Domains (3) summary
    COG2319
    Location:407704
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:454529
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:407784
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_017012071.1XP_016867560.1  WD repeat-containing protein 91 isoform X4

RNA

  1. XR_927458.3 RNA Sequence

  2. XR_001744649.2 RNA Sequence

    Related
    ENST00000682250.1
  3. XR_927459.3 RNA Sequence

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