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SV40gp6 large T antigen [ Macaca mulatta polyomavirus 1 ]

Gene ID: 29031019, updated on 18-Aug-2023

Summary

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Gene symbol
SV40gp6
Gene description
large T antigen
Locus tag
SV40gp6
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta polyomavirus 1
Lineage
Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Sepolyvirales; Polyomaviridae; Betapolyomavirus
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Genomic context

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Sequence:
NC_001669.1 (2691..5163, complement)

NC_001669.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene miscRNA Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001669.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Study of SV40 large T antigen nucleotide specificity for DNA unwinding. Wang D, et al. Virol J, 2017 Apr 14. PMID 28410592, Free PMC Article
  2. Intracistronic complementation in the simian virus 40 A gene. Tornow J, et al. Proc Natl Acad Sci U S A, 1983 Oct. PMID 6312452, Free PMC Article
  3. Mutational analysis of simian virus 40 T antigen: isolation and characterization of mutants with deletions in the T-antigen gene. Pipas JM, et al. Mol Cell Biol, 1983 Feb. PMID 6300656, Free PMC Article
  4. Construction and characterization of viable deletion mutants of simian virus 40 lacking sequences near the 3' end of the early region. Polvino-Bodnar M, et al. J Virol, 1982 Aug. PMID 6287029, Free PMC Article
  5. Nucleotide sequence of simian virus 40 DNA: structure of the middle segment of the HindII + III restriction fragment B (sixth part of the T antigen gene) and codon usage. Van Heuverswyn H, et al. Eur J Biochem, 1980 May. PMID 6280997

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. findings show STING transcription is suppressed in 293T cells but is not driven by SV40 LT; SV40 LT does inhibit cGAS-STING interferon induction but through a mechanism distinct from other DNA virus oncogenes; results indicate that while SV40 LT can inhibit cGAS-STING interferon induction, it does so in an unanticipated manner
    Title: SV40 Large T Antigen Is Not Responsible for the Loss of STING in 293T Cells but Can Inhibit cGAS-STING Interferon Induction.
  2. Data show that p53 binds to the viral DNA at the SV40 large T-antigen (T-ag) promoter region and halts the progress of the infection.
    Title: p53 elevation in human cells halt SV40 infection by inhibiting T-ag expression.
  3. The authors identified four residues in the nucleotide pocket of large T antigen, cS430, tK419, cW393 and cL557 that selectively displayed more profound impact on using certain nucleotides for large T antigen DNA helicase activity.
    Title: Study of SV40 large T antigen nucleotide specificity for DNA unwinding.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
large T antigen
NP_043127.1
  • putative

VOG classification

Description:

  • VOGd0053 [L] Large tumor antigen
  • DNA Replication, Repair and Nucleotide Metabolism

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001669.1 Reference assembly

    Range
    2691..5163 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_043127.1 large T antigen [Macaca mulatta polyomavirus 1]

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P03070
    UniProtKB/TrEMBL
    A7XWL1, Q9DH70
    Conserved Domains (1) summary
    PHA02624
    Location:1 → 632
    PHA02624; large T antigen; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P03070.3

Gene LinkOut

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