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SV40gp6 large T antigen [ Macaca mulatta polyomavirus 1 ]

Gene ID: 29031019, updated on 17-Aug-2018

Summary

Gene symbol
SV40gp6
Gene description
large T antigen
Locus tag
SV40gp6
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Macaca mulatta polyomavirus 1 (old-name: Polyomavirus maccacae)
Lineage
Viruses; dsDNA viruses, no RNA stage; Polyomaviridae

Genomic context

Sequence:
NC_001669.1 (2691..5163, complement)

NC_001669.1Genomic Context describing neighboring genes Neighboring gene agnoprotein Neighboring gene VP2 Neighboring gene hypothetical protein Neighboring gene Major capsid protein VP1 Neighboring gene miscRNA Neighboring gene Small T antigen Neighboring gene hypothetical protein

General protein information

Preferred Names
large T antigen
YP_003708382.1
  • large T antigen; binds to the viral origin of replication; regulates the transcription of early region mRNA; helicase activity facilitates movement of the virion DNA replication fork; the small T antigen shares a region in common with the large T antigen known as the J-domain; the J-domain is required for multiple processes including assembly, viral genomic DNA replication and transcription; The polyomaviruses are non-enveloped dsDNA viruses; the viral genome is organized into two divergent transcriptional units known as early and late regions; mRNAs from the early region encode the viral small and large t-antigens; the small T antigen and large T antigen are expressed upon entry into the host nucleus early in the viral lifecycle

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001669.1 Reference assembly

    Range
    2691..5163 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_003708382.1 large T antigen [Macaca mulatta polyomavirus 1]

    See identical proteins and their annotated locations for YP_003708382.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P03070
    UniProtKB/TrEMBL
    Q9DH70
    Conserved Domains (4) summary
    smart00271
    Location:1367
    DnaJ; DnaJ molecular chaperone homology domain
    PHA02624
    Location:1632
    PHA02624; large T antigen; Provisional
    pfam02217
    Location:136229
    T_Ag_DNA_bind; Origin of replication binding protein
    pfam06431
    Location:265683
    Polyoma_lg_T_C; Polyomavirus large T antigen C-terminus
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