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ANPEP alanyl aminopeptidase, membrane [ Homo sapiens (human) ]

Gene ID: 290, updated on 3-Feb-2021

Summary

Official Symbol
ANPEPprovided by HGNC
Official Full Name
alanyl aminopeptidase, membraneprovided by HGNC
Primary source
HGNC:HGNC:500
See related
Ensembl:ENSG00000166825 MIM:151530
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APN; CD13; LAP1; P150; PEPN; GP150
Summary
Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. This membrane-bound zinc metalloprotease is known to serve as a receptor for the HCoV-229E alphacoronavirus as well as other non-human coronaviruses. This gene has also been shown to promote angiogenesis, tumor growth, and metastasis and defects in this gene are associated with various types of leukemia and lymphoma. [provided by RefSeq, Apr 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for disease process.
Expression
Biased expression in duodenum (RPKM 1193.1), small intestine (RPKM 1007.5) and 5 other tissues See more
Orthologs
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Genomic context

See ANPEP in Genome Data Viewer
Location:
15q26.1
Exon count:
21
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (89784895..89814852, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (90328126..90358084, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L15 pseudogene 1 Neighboring gene mesoderm posterior bHLH transcription factor 2 Neighboring gene ANPEP proximal promoter Neighboring gene FOXA motif-containing MPRA enhancer 170 Neighboring gene ANPEP distal promoter Neighboring gene uncharacterized LOC105370965 Neighboring gene ARPIN-AP3S2 readthrough Neighboring gene adaptor related protein complex 3 subunit sigma 2 Neighboring gene microRNA 5094

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
An atlas of genetic influences on human blood metabolites.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
aminopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
metalloaminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metallopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space HDA PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lysosomal membrane HDA PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
secretory granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
aminopeptidase N
Names
AP-M
AP-N
alanyl (membrane) aminopeptidase
aminopeptidase M
hAPN
membrane alanyl aminopeptidase
microsomal aminopeptidase
myeloid plasma membrane glycoprotein CD13
NP_001141.2
NP_001368852.1
NP_001368853.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001150.3NP_001141.2  aminopeptidase N precursor

    See identical proteins and their annotated locations for NP_001141.2

    Status: REVIEWED

    Source sequence(s)
    AB209918, AC018988, AC079075, BC058928, BQ879097
    Consensus CDS
    CCDS10356.1
    UniProtKB/Swiss-Prot
    P15144
    UniProtKB/TrEMBL
    A0A024RC61, Q59E93
    Related
    ENSP00000300060.6, ENST00000300060.7
    Conserved Domains (2) summary
    cd09601
    Location:84545
    M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
    pfam11838
    Location:619946
    ERAP1_C; ERAP1-like C-terminal domain
  2. NM_001381923.1NP_001368852.1  aminopeptidase N

    Status: REVIEWED

    Source sequence(s)
    AC018988, AC079075
    Related
    ENSP00000453413.2, ENST00000560137.2
    Conserved Domains (2) summary
    cd09601
    Location:84545
    M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
    pfam11838
    Location:619946
    ERAP1_C; ERAP1-like C-terminal domain
  3. NM_001381924.1NP_001368853.1  aminopeptidase N

    Status: REVIEWED

    Source sequence(s)
    AC018988, AC079075
    Conserved Domains (2) summary
    cd09601
    Location:84545
    M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
    pfam11838
    Location:619946
    ERAP1_C; ERAP1-like C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    89784895..89814852 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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