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ANPEP alanyl aminopeptidase, membrane [ Homo sapiens (human) ]

Gene ID: 290, updated on 23-Nov-2023

Summary

Official Symbol
ANPEPprovided by HGNC
Official Full Name
alanyl aminopeptidase, membraneprovided by HGNC
Primary source
HGNC:HGNC:500
See related
Ensembl:ENSG00000166825 MIM:151530; AllianceGenome:HGNC:500
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APN; AP-M; AP-N; CD13; LAP1; P150; PEPN; hAPN; GP150
Summary
Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. This membrane-bound zinc metalloprotease is known to serve as a receptor for the HCoV-229E alphacoronavirus as well as other non-human coronaviruses. This gene has also been shown to promote angiogenesis, tumor growth, and metastasis and defects in this gene are associated with various types of leukemia and lymphoma. [provided by RefSeq, Apr 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for disease process.
Expression
Biased expression in duodenum (RPKM 1193.1), small intestine (RPKM 1007.5) and 5 other tissues See more
Orthologs
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Genomic context

See ANPEP in Genome Data Viewer
Location:
15q26.1
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (89784895..89814852, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (87540783..87570713, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (90328126..90358084, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6805 Neighboring gene mitochondrial ribosomal protein L15 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90310867-90311584 Neighboring gene uncharacterized LOC124903550 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6806 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10055 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:90326293-90326955 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr15:90326956-90327617 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90327618-90328280 Neighboring gene mesoderm posterior bHLH transcription factor 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90335518-90336018 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:90347169-90348368 Neighboring gene ANPEP proximal promoter Neighboring gene FOXA motif-containing MPRA enhancer 170 Neighboring gene ANPEP distal promoter Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90365008-90365508 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90365509-90366009 Neighboring gene uncharacterized LOC124903551 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90367927-90368600 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10056 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:90370583-90371474 Neighboring gene ARPIN-AP3S2 readthrough Neighboring gene uncharacterized LOC124903552 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:90380077-90381276 Neighboring gene adaptor related protein complex 3 subunit sigma 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables aminopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
enables metalloaminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metallopeptidase activity TAS
Traceable Author Statement
more info
PubMed 
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
aminopeptidase N
Names
alanyl (membrane) aminopeptidase
aminopeptidase M
membrane alanyl aminopeptidase
microsomal aminopeptidase
myeloid plasma membrane glycoprotein CD13
NP_001141.2
NP_001368852.1
NP_001368853.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001150.3NP_001141.2  aminopeptidase N precursor

    See identical proteins and their annotated locations for NP_001141.2

    Status: REVIEWED

    Source sequence(s)
    AB209918, AC018988, AC079075, BC058928, BQ879097
    Consensus CDS
    CCDS10356.1
    UniProtKB/Swiss-Prot
    P15144, Q16728, Q6GT90, Q8IUK3, Q8IVH3, Q9UCE0
    UniProtKB/TrEMBL
    Q59E93
    Related
    ENSP00000300060.6, ENST00000300060.7
    Conserved Domains (2) summary
    cd09601
    Location:84545
    M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
    pfam11838
    Location:619946
    ERAP1_C; ERAP1-like C-terminal domain
  2. NM_001381923.1NP_001368852.1  aminopeptidase N

    Status: REVIEWED

    Source sequence(s)
    AC018988, AC079075
    Consensus CDS
    CCDS10356.1
    UniProtKB/Swiss-Prot
    P15144, Q16728, Q6GT90, Q8IUK3, Q8IVH3, Q9UCE0
    UniProtKB/TrEMBL
    Q59E93
    Related
    ENSP00000453413.2, ENST00000560137.2
    Conserved Domains (2) summary
    cd09601
    Location:84545
    M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
    pfam11838
    Location:619946
    ERAP1_C; ERAP1-like C-terminal domain
  3. NM_001381924.1NP_001368853.1  aminopeptidase N

    Status: REVIEWED

    Source sequence(s)
    AC018988, AC079075
    Consensus CDS
    CCDS10356.1
    UniProtKB/Swiss-Prot
    P15144, Q16728, Q6GT90, Q8IUK3, Q8IVH3, Q9UCE0
    UniProtKB/TrEMBL
    Q59E93
    Conserved Domains (2) summary
    cd09601
    Location:84545
    M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
    pfam11838
    Location:619946
    ERAP1_C; ERAP1-like C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    89784895..89814852 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    87540783..87570713 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)