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KLF15 KLF transcription factor 15 [ Homo sapiens (human) ]

Gene ID: 28999, updated on 20-Nov-2022

Summary

Official Symbol
KLF15provided by HGNC
Official Full Name
KLF transcription factor 15provided by HGNC
Primary source
HGNC:HGNC:14536
See related
Ensembl:ENSG00000163884 MIM:606465; AllianceGenome:HGNC:14536
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KKLF
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of peptidyl-lysine acetylation and positive regulation of transcription by RNA polymerase II. Located in nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in fat (RPKM 10.7), ovary (RPKM 8.2) and 17 other tissues See more
Orthologs
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Genomic context

See KLF15 in Genome Data Viewer
Location:
3q21.3
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (126288125..126357408, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (129075102..129089915, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (126061478..126076251, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 1 family member L1 Neighboring gene ALDH1L1 antisense RNA 2 Neighboring gene Sharpr-MPRA regulatory region 2719 Neighboring gene uncharacterized LOC124909426 Neighboring gene uncharacterized LOC107986124 Neighboring gene uncharacterized LOC105374088 Neighboring gene uncharacterized LOC107986044 Neighboring gene CFAP100 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp779M1320

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cardiac muscle hypertrophy in response to stress IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to peptide IEA
Inferred from Electronic Annotation
more info
 
involved_in glial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of peptidyl-lysine acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in podocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of glucose import IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to insulin IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Krueppel-like factor 15
Names
Kruppel like factor 15
kidney-enriched Kruppel-like factor
kidney-enriched krueppel-like factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014079.4NP_054798.1  Krueppel-like factor 15

    See identical proteins and their annotated locations for NP_054798.1

    Status: VALIDATED

    Source sequence(s)
    AC063919, BC036733
    Consensus CDS
    CCDS3036.1
    UniProtKB/Swiss-Prot
    Q9UIH9
    Related
    ENSP00000296233.3, ENST00000296233.4
    Conserved Domains (2) summary
    COG5189
    Location:306401
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:323345
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    126288125..126357408 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512743.3XP_011511045.1  Krueppel-like factor 15 isoform X1

    Conserved Domains (4) summary
    sd00017
    Location:342364
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:340364
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:386411
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:342421
    zf-C2H2_8; C2H2-type zinc ribbon

RNA

  1. XR_001740124.3 RNA Sequence

  2. XR_924449.3 RNA Sequence

  3. XR_002959509.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    129075102..129089915 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)