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KLF15 Kruppel like factor 15 [ Homo sapiens (human) ]

Gene ID: 28999, updated on 7-Jun-2020

Summary

Official Symbol
KLF15provided by HGNC
Official Full Name
Kruppel like factor 15provided by HGNC
Primary source
HGNC:HGNC:14536
See related
Ensembl:ENSG00000163884 MIM:606465
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KKLF
Expression
Broad expression in fat (RPKM 10.7), ovary (RPKM 8.2) and 17 other tissues See more
Orthologs

Genomic context

See KLF15 in Genome Data Viewer
Location:
3q21.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (126288121..126357408, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (126061478..126076236, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase 1 family member L1 Neighboring gene uncharacterized LOC105374083 Neighboring gene RNA, U1 small nuclear 30, pseudogene Neighboring gene ALDH1L1 antisense RNA 2 Neighboring gene Sharpr-MPRA regulatory region 2719 Neighboring gene uncharacterized LOC107986124 Neighboring gene uncharacterized LOC105374088 Neighboring gene uncharacterized LOC107986044 Neighboring gene CCDC37 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp779M1320

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cardiac muscle hypertrophy in response to stress IEA
Inferred from Electronic Annotation
more info
 
cellular glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
cellular response to peptide IEA
Inferred from Electronic Annotation
more info
 
glial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
glomerular visceral epithelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of peptidyl-lysine acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of glucose import IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to insulin IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Krueppel-like factor 15
Names
kidney-enriched Kruppel-like factor
kidney-enriched krueppel-like factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014079.4NP_054798.1  Krueppel-like factor 15

    See identical proteins and their annotated locations for NP_054798.1

    Status: VALIDATED

    Source sequence(s)
    AC063919, BC036733
    Consensus CDS
    CCDS3036.1
    UniProtKB/Swiss-Prot
    Q9UIH9
    Related
    ENSP00000296233.3, ENST00000296233.4
    Conserved Domains (2) summary
    COG5189
    Location:306401
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:323345
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    126288121..126357408 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512743.2XP_011511045.1  Krueppel-like factor 15 isoform X1

    Conserved Domains (4) summary
    sd00017
    Location:342364
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:340364
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:386411
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:342421
    zf-C2H2_8; C2H2-type zinc ribbon
  2. XM_005247400.4XP_005247457.1  Krueppel-like factor 15 isoform X2

    See identical proteins and their annotated locations for XP_005247457.1

    UniProtKB/Swiss-Prot
    Q9UIH9
    Conserved Domains (2) summary
    COG5189
    Location:306401
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:323345
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. XR_001740124.2 RNA Sequence

  2. XR_924449.2 RNA Sequence

  3. XR_002959509.1 RNA Sequence

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