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ASTE1 asteroid homolog 1 [ Homo sapiens (human) ]

Gene ID: 28990, updated on 1-Jun-2020

Summary

Official Symbol
ASTE1provided by HGNC
Official Full Name
asteroid homolog 1provided by HGNC
Primary source
HGNC:HGNC:25021
See related
Ensembl:ENSG00000034533
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HT001
Expression
Ubiquitous expression in testis (RPKM 3.6), thyroid (RPKM 3.3) and 25 other tissues See more
Orthologs

Genomic context

See ASTE1 in Genome Data Viewer
Location:
3q22.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (131013873..131026854, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (130732721..130745698, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATPase secretory pathway Ca2+ transporting 1 Neighboring gene cysteine and glycine rich protein 2 pseudogene Neighboring gene makorin ring finger protein 1 pseudogene Neighboring gene uncharacterized LOC107986024 Neighboring gene NIMA related kinase 11 Neighboring gene RNA, U6 small nuclear 726, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129980

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nuclease activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001288950.1NP_001275879.1  protein asteroid homolog 1 isoform 1

    See identical proteins and their annotated locations for NP_001275879.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK294156, BC069265, BM992874
    Consensus CDS
    CCDS75007.1
    UniProtKB/Swiss-Prot
    Q2TB18
    UniProtKB/TrEMBL
    D6RG30
    Related
    ENSP00000426421.1, ENST00000514044.5
    Conserved Domains (1) summary
    cl14812
    Location:197
    PIN_SF; PIN (PilT N terminus) domain: Superfamily
  2. NM_014065.4NP_054784.2  protein asteroid homolog 1 isoform 2

    See identical proteins and their annotated locations for NP_054784.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK027806, AK294156, BC069265
    Consensus CDS
    CCDS3068.1
    UniProtKB/Swiss-Prot
    Q2TB18
    Related
    ENSP00000264992.3, ENST00000264992.7
    Conserved Domains (2) summary
    pfam12813
    Location:116168
    XPG_I_2; XPG domain containing
    cl14812
    Location:197
    PIN_SF; PIN (PilT N terminus) domain: Superfamily

RNA

  1. NR_110229.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' region and lacks an alternate internal exon and contains an alternate internal exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK294156, BC069265, BM992874

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    131013873..131026854 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453486.1XP_024309254.1  protein asteroid homolog 1 isoform X1

    Conserved Domains (2) summary
    pfam12813
    Location:116168
    XPG_I_2; XPG domain containing
    cl14812
    Location:197
    PIN_SF; PIN (PilT N terminus) domain: Superfamily
  2. XM_017006268.2XP_016861757.1  protein asteroid homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    Q2TB18
    Conserved Domains (2) summary
    pfam12813
    Location:116168
    XPG_I_2; XPG domain containing
    cl14812
    Location:197
    PIN_SF; PIN (PilT N terminus) domain: Superfamily
  3. XM_017006267.2XP_016861756.1  protein asteroid homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    Q2TB18
    Conserved Domains (2) summary
    pfam12813
    Location:116168
    XPG_I_2; XPG domain containing
    cl14812
    Location:197
    PIN_SF; PIN (PilT N terminus) domain: Superfamily
  4. XM_017006266.2XP_016861755.1  protein asteroid homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    Q2TB18
    Related
    ENSP00000421019.1, ENST00000507978.5
    Conserved Domains (2) summary
    pfam12813
    Location:116168
    XPG_I_2; XPG domain containing
    cl14812
    Location:197
    PIN_SF; PIN (PilT N terminus) domain: Superfamily
  5. XM_017006269.2XP_016861758.1  protein asteroid homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    Q2TB18
    Conserved Domains (2) summary
    pfam12813
    Location:116168
    XPG_I_2; XPG domain containing
    cl14812
    Location:197
    PIN_SF; PIN (PilT N terminus) domain: Superfamily
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