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GRIK3 glutamate ionotropic receptor kainate type subunit 3 [ Homo sapiens (human) ]

Gene ID: 2899, updated on 8-Jul-2018
Official Symbol
GRIK3provided by HGNC
Official Full Name
glutamate ionotropic receptor kainate type subunit 3provided by HGNC
Primary source
HGNC:HGNC:4581
See related
Ensembl:ENSG00000163873 MIM:138243; Vega:OTTHUMG00000004189
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EAA5; GLR7; GLUR7; GluK3; GluR7a
Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 3.5), adrenal (RPKM 0.5) and 6 other tissues See more
Orthologs
See GRIK3 in Genome Data Viewer
Location:
1p34.3
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (36795527..37034243, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (37261128..37499844, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984941 Neighboring gene ferritin light chain pseudogene 18 Neighboring gene uncharacterized LOC105378648 Neighboring gene microRNA 4255 Neighboring gene RNA, U6 small nuclear 636, pseudogene

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
G-protein coupled glutamate receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
glutamate receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
ionotropic glutamate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of synaptic transmission, glutamatergic ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
regulation of membrane potential ISS
Inferred from Sequence or Structural Similarity
more info
 
synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
kainate selective glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perikaryon ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
terminal bouton ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
glutamate receptor ionotropic, kainate 3
Names
dJ1090M5.1 (glutamate receptor, ionotropic, kainate 3 (GLUR7))
excitatory amino acid receptor 5
gluR-7
glutamate receptor 7

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011447.1 RefSeqGene

    Range
    5001..243717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000831.3NP_000822.2  glutamate receptor ionotropic, kainate 3 precursor

    See identical proteins and their annotated locations for NP_000822.2

    Status: REVIEWED

    Source sequence(s)
    AC117945, AJ249210, AW898512, BG057125, BG818719, BQ446793, DR003075, DT217951, U16127
    Consensus CDS
    CCDS416.1
    UniProtKB/Swiss-Prot
    Q13003
    Related
    ENSP00000362183.3, OTTHUMP00000004360, ENST00000373091.7, OTTHUMT00000012053
    Conserved Domains (4) summary
    cd06393
    Location:34417
    PBP1_iGluR_Kainate_GluR5_7; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR5-7 subunits of Kainate receptor
    cd13723
    Location:433801
    PBP2_iGluR_Kainate_GluR7; GluR7 subtype of kainate receptor, type 2 periplasmic-binding fold superfamily
    pfam00060
    Location:564832
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:55398
    ANF_receptor; Receptor family ligand binding region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    36795527..37034243 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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