Format

Send to:

Choose Destination

MCTS1 MCTS1 re-initiation and release factor [ Homo sapiens (human) ]

Gene ID: 28985, updated on 11-Sep-2019

Summary

Official Symbol
MCTS1provided by HGNC
Official Full Name
MCTS1 re-initiation and release factorprovided by HGNC
Primary source
HGNC:HGNC:23357
See related
Ensembl:ENSG00000232119 MIM:300587
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCT1; MCT-1
Expression
Ubiquitous expression in lymph node (RPKM 3.6), brain (RPKM 3.4) and 25 other tissues See more
Orthologs

Genomic context

See MCTS1 in Genome Data Viewer
Location:
Xq24
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (120604101..120621159)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (119737744..119755014)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RNA, U7 small nuclear 86 pseudogene Neighboring gene cullin 4B Neighboring gene Sharpr-MPRA regulatory region 11856 Neighboring gene C1GALT1 specific chaperone 1 Neighboring gene H3 histone pseudogene 46

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39637

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
IRES-dependent viral translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
formation of translation preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
formation of translation preinitiation complex IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
ribosome disassembly IDA
Inferred from Direct Assay
more info
PubMed 
translation reinitiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
malignant T-cell-amplified sequence 1
Names
malignant T-cell amplified sequence 1
multiple copies T-cell malignancies
multiple copies in T-cell lymphoma-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001137554.2NP_001131026.1  malignant T-cell-amplified sequence 1 isoform 2

    See identical proteins and their annotated locations for NP_001131026.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AA375691, AC011890, AK294834, AW957695, BM671542
    Consensus CDS
    CCDS48160.1
    UniProtKB/Swiss-Prot
    Q9ULC4
    Related
    ENSP00000360365.3, ENST00000371315.3
    Conserved Domains (2) summary
    cd11609
    Location:581
    MCT1_N; N-terminal domain of multiple copies T cell malignancies 1 and related proteins
    COG2016
    Location:24178
    Tma20; Predicted ribosome-associated RNA-binding protein Tma20, contains PUA domain [Translation, ribosomal structure and biogenesis]
  2. NM_014060.3NP_054779.1  malignant T-cell-amplified sequence 1 isoform 1

    See identical proteins and their annotated locations for NP_054779.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AC011890, BC001013, BM671542, BP226595
    Consensus CDS
    CCDS14601.1
    UniProtKB/Swiss-Prot
    Q9ULC4
    Related
    ENSP00000360367.5, ENST00000371317.10
    Conserved Domains (2) summary
    cd11609
    Location:480
    MCT1_N; N-terminal domain of multiple copies T cell malignancies 1 and related proteins
    COG2016
    Location:23177
    Tma20; Predicted ribosome-associated RNA-binding protein Tma20, contains PUA domain [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    120604101..120621159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_938549.2 RNA Sequence

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_021160027.1 Reference GRCh38.p13 PATCHES

    Range
    4169..21227
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center