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MCTS1 MCTS1 re-initiation and release factor [ Homo sapiens (human) ]

Gene ID: 28985, updated on 6-Nov-2022

Summary

Official Symbol
MCTS1provided by HGNC
Official Full Name
MCTS1 re-initiation and release factorprovided by HGNC
Primary source
HGNC:HGNC:23357
See related
Ensembl:ENSG00000232119 MIM:300587; AllianceGenome:HGNC:23357
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCT1; MCT-1
Summary
Predicted to enable translation initiation factor activity. Involved in IRES-dependent viral translational initiation; formation of translation preinitiation complex; and ribosome disassembly. Located in cytosol and plasma membrane. Colocalizes with cytosolic small ribosomal subunit. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lymph node (RPKM 3.6), brain (RPKM 3.4) and 25 other tissues See more
Orthologs
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Genomic context

See MCTS1 in Genome Data Viewer
Location:
Xq24
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (120604101..120621159)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (118979555..118996612)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (119737956..119755014)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene cullin 4B Neighboring gene H3K27ac hESC enhancers GRCh37_chrX:119693886-119694771 and GRCh37_chrX:119694772-119695656 Neighboring gene uncharacterized LOC124905210 Neighboring gene small nucleolar RNA U3 Neighboring gene C1GALT1 specific chaperone 1 Neighboring gene H3 histone pseudogene 46

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39637

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
malignant T-cell-amplified sequence 1
Names
malignant T-cell amplified sequence 1
multiple copies T-cell malignancies
multiple copies in T-cell lymphoma-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001137554.2NP_001131026.1  malignant T-cell-amplified sequence 1 isoform 2

    See identical proteins and their annotated locations for NP_001131026.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AA375691, AC011890, AK294834, AW957695, BM671542
    Consensus CDS
    CCDS48160.1
    UniProtKB/Swiss-Prot
    Q9ULC4
    Related
    ENSP00000360365.3, ENST00000371315.3
    Conserved Domains (2) summary
    cd11609
    Location:581
    MCT1_N; N-terminal domain of multiple copies T cell malignancies 1 and related proteins
    cd21155
    Location:81176
    PUA_MCTS-1-like; PUA RNA-binding domain of malignant T cell-amplified sequence 1 and related proteins
  2. NM_014060.3NP_054779.1  malignant T-cell-amplified sequence 1 isoform 1

    See identical proteins and their annotated locations for NP_054779.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AC011890, BC001013, BM671542, BP226595
    Consensus CDS
    CCDS14601.1
    UniProtKB/Swiss-Prot
    Q502X6, Q9ULC4
    Related
    ENSP00000360367.5, ENST00000371317.10
    Conserved Domains (2) summary
    cd11609
    Location:480
    MCT1_N; N-terminal domain of multiple copies T cell malignancies 1 and related proteins
    cd21155
    Location:80175
    PUA_MCTS-1-like; PUA RNA-binding domain of malignant T cell-amplified sequence 1 and related proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    120604101..120621159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160027.1 Reference GRCh38.p14 PATCHES

    Range
    4169..21227
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    118979555..118996612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)