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RGCC regulator of cell cycle [ Homo sapiens (human) ]

Gene ID: 28984, updated on 24-Nov-2020

Summary

Official Symbol
RGCCprovided by HGNC
Official Full Name
regulator of cell cycleprovided by HGNC
Primary source
HGNC:HGNC:20369
See related
Ensembl:ENSG00000102760 MIM:610077
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RGC32; RGC-32; C13orf15; bA157L14.2
Summary
This gene is thought to regulate cell cycle progression. It is induced by p53 in response to DNA damage, or by sublytic levels of complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the cytoplasm during interphase and to centrosomes during mitosis. The protein forms a complex with polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression. [provided by RefSeq, Jul 2008]
Expression
Biased expression in bone marrow (RPKM 99.1), lung (RPKM 65.2) and 11 other tissues See more
Orthologs

Genomic context

See RGCC in Genome Data Viewer
Location:
13q14.11
Exon count:
7
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (41457411..41470876)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (42031542..42045013)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 7 subfamily E member 155 pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 37 pseudogene Neighboring gene uncharacterized LOC105370174 Neighboring gene uncharacterized LOC105370175 Neighboring gene microRNA 5006 Neighboring gene von Willebrand factor A domain containing 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
GeneReviews: Not available
Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0564, MGC87338

Gene Ontology Provided by GOA

Function Evidence Code Pubs
R-SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
Traceable Author Statement
more info
 
activation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
complement activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
fibroblast activation ISS
Inferred from Sequence or Structural Similarity
more info
 
mitotic cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell-cell adhesion mediated by cadherin IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of exit from mitosis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of fibroblast growth factor production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of mitotic cell cycle phase transition IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of collagen biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cyclin-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cyclin-dependent protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endothelial cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of extracellular matrix assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of extracellular matrix constituent secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of stress fiber assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
regulator of cell cycle RGCC
Names
response gene to complement 32 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014059.3NP_054778.2  regulator of cell cycle RGCC

    See identical proteins and their annotated locations for NP_054778.2

    Status: REVIEWED

    Source sequence(s)
    BC066334, DB451897
    Consensus CDS
    CCDS41880.1
    UniProtKB/Swiss-Prot
    Q9H4X1
    Related
    ENSP00000368664.3, ENST00000379359.4
    Conserved Domains (1) summary
    pfam15151
    Location:26137
    RGCC; Response gene to complement 32 protein family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    41457411..41470876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001749538.1 RNA Sequence

  2. XR_941565.1 RNA Sequence

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