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FLVCR1 feline leukemia virus subgroup C cellular receptor 1 [ Homo sapiens (human) ]

Gene ID: 28982, updated on 12-Aug-2018
Official Symbol
FLVCR1provided by HGNC
Official Full Name
feline leukemia virus subgroup C cellular receptor 1provided by HGNC
Primary source
HGNC:HGNC:24682
See related
Ensembl:ENSG00000162769 MIM:609144; Vega:OTTHUMG00000036924
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PCA; AXPC1; FLVCR; PCARP; MFSD7B
Summary
This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein is a heme transporter that may play a critical role in erythropoiesis by protecting developing erythroid cells from heme toxicity. This gene may play a role in posterior column ataxia with retinitis pigmentosa and the hematological disorder Diamond-Blackfan syndrome. [provided by RefSeq, Jan 2011]
Expression
Broad expression in small intestine (RPKM 9.2), duodenum (RPKM 4.1) and 21 other tissues See more
Orthologs
See FLVCR1 in Genome Data Viewer
Location:
1q32.3
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (212858255..212899363)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (213031597..213072705)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene FLVCR1 divergent transcript Neighboring gene ribosomal protein S28 pseudogene 2 Neighboring gene vasohibin 2 Neighboring gene angel homolog 2 Neighboring gene ribosomal protein S6 kinase C1 Neighboring gene VISTA enhancer hs1324

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ33420

Gene Ontology Provided by GOA

Function Evidence Code Pubs
heme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heme transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heme transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
heme transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
heme transporter activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transporter activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
blood vessel development IEA
Inferred from Electronic Annotation
more info
 
cellular iron ion homeostasis TAS
Traceable Author Statement
more info
 
embryonic digit morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic skeletal system morphogenesis IEA
Inferred from Electronic Annotation
more info
 
erythrocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
erythrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
erythrocyte maturation IEA
Inferred from Electronic Annotation
more info
 
head morphogenesis IEA
Inferred from Electronic Annotation
more info
 
heme export IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heme export IMP
Inferred from Mutant Phenotype
more info
PubMed 
heme transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
mitochondrial transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial transport IDA
Inferred from Direct Assay
more info
PubMed 
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
regulation of organ growth IEA
Inferred from Electronic Annotation
more info
 
spleen development IEA
Inferred from Electronic Annotation
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
feline leukemia virus subgroup C receptor-related protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028131.1 RefSeqGene

    Range
    5001..46109
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014053.3NP_054772.1  feline leukemia virus subgroup C receptor-related protein 1

    See identical proteins and their annotated locations for NP_054772.1

    Status: REVIEWED

    Source sequence(s)
    AC104333, AF118637, AK090739, AK314481, GD138340
    Consensus CDS
    CCDS1510.1
    UniProtKB/Swiss-Prot
    Q9Y5Y0
    UniProtKB/TrEMBL
    B2RB38
    Related
    ENSP00000355938.4, OTTHUMP00000035011, ENST00000366971.8, OTTHUMT00000089678
    Conserved Domains (2) summary
    cd06174
    Location:111512
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:113478
    MFS_1; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    212858255..212899363
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509446.3XP_011507748.1  feline leukemia virus subgroup C receptor-related protein 1 isoform X1

    Conserved Domains (2) summary
    cd06174
    Location:111475
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:113406
    MFS_1; Major Facilitator Superfamily
  2. XM_011509447.2XP_011507749.1  feline leukemia virus subgroup C receptor-related protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011507749.1

    Conserved Domains (2) summary
    cd06174
    Location:111294
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:113294
    MFS_1; Major Facilitator Superfamily
  3. XM_011509448.1XP_011507750.1  feline leukemia virus subgroup C receptor-related protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011507750.1

    Conserved Domains (2) summary
    cd06174
    Location:111294
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:113294
    MFS_1; Major Facilitator Superfamily

RNA

  1. XR_247024.3 RNA Sequence

  2. XR_426771.1 RNA Sequence

  3. XR_426772.3 RNA Sequence

  4. XR_921769.1 RNA Sequence

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