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MRPL42 mitochondrial ribosomal protein L42 [ Homo sapiens (human) ]

Gene ID: 28977, updated on 24-Nov-2020

Summary

Official Symbol
MRPL42provided by HGNC
Official Full Name
mitochondrial ribosomal protein L42provided by HGNC
Primary source
HGNC:HGNC:14493
See related
Ensembl:ENSG00000198015 MIM:611847
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L31MT; L42MT; S32MT; MRPL31; MRPS32; PTD007; RPML31; HSPC204; MRP-L31; MRP-L42; MRP-S32
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein identified as belonging to both the 28S and the 39S subunits. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 4q, 6p, 6q, 7p, and 15q. [provided by RefSeq, May 2011]
Expression
Ubiquitous expression in adrenal (RPKM 12.4), thyroid (RPKM 10.6) and 25 other tissues See more
Orthologs

Genomic context

See MRPL42 in Genome Data Viewer
Location:
12q22
Exon count:
7
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (93467514..93516214)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (93861266..93897548)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene nudix hydrolase 4 Neighboring gene uncharacterized LOC112267866 Neighboring gene ubiquitin conjugating enzyme E2 N Neighboring gene RNA, 7SL, cytoplasmic 737, pseudogene Neighboring gene SOCS2 antisense RNA 1 Neighboring gene suppressor of cytokine signaling 2 Neighboring gene phosphoglycerate mutase 1 (brain) pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Many sequence variants affecting diversity of adult human height.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev is identified to have a physical interaction with mitochondrial ribosomal protein L42 (MRPL42) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
translation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
39S ribosomal protein L42, mitochondrial
Names
28S ribosomal protein S32, mitochondrial
39S ribosomal protein L31, mitochondrial
mitochondrial large ribosomal subunit protein mL42

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014050.4NP_054769.1  39S ribosomal protein L42, mitochondrial precursor

    See identical proteins and their annotated locations for NP_054769.1

    Status: REVIEWED

    Source sequence(s)
    AC025260
    Consensus CDS
    CCDS9045.1
    UniProtKB/Swiss-Prot
    Q9Y6G3
    UniProtKB/TrEMBL
    A0A024RBG3
    Related
    ENSP00000449884.1, ENST00000549982.5
    Conserved Domains (1) summary
    pfam10210
    Location:47142
    MRP-S32; Mitochondrial 28S ribosomal protein S32
  2. NM_172177.5NP_751917.1  39S ribosomal protein L42, mitochondrial precursor

    See identical proteins and their annotated locations for NP_751917.1

    Status: REVIEWED

    Source sequence(s)
    AC025260
    Consensus CDS
    CCDS9045.1
    UniProtKB/Swiss-Prot
    Q9Y6G3
    UniProtKB/TrEMBL
    A0A024RBG3
    Related
    ENSP00000447547.1, ENST00000552217.6
    Conserved Domains (1) summary
    pfam10210
    Location:47142
    MRP-S32; Mitochondrial 28S ribosomal protein S32

RNA

  1. NR_038159.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC025260
  2. NR_038160.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC025260
  3. NR_038161.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC025260

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    93467514..93516214
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_172178.2: Suppressed sequence

    Description
    NM_172178.2: This RefSeq was permanently suppressed because the transcript is a nonsense-mediated mRNA decay (NMD) candidate.
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