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SPCS1 signal peptidase complex subunit 1 [ Homo sapiens (human) ]

Gene ID: 28972, updated on 4-Jul-2021

Summary

Official Symbol
SPCS1provided by HGNC
Official Full Name
signal peptidase complex subunit 1provided by HGNC
Primary source
HGNC:HGNC:23401
See related
Ensembl:ENSG00000114902 MIM:610358
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPC1; SPC12; HSPC033; YJR010C-A
Expression
Ubiquitous expression in kidney (RPKM 60.9), colon (RPKM 57.9) and 25 other tissues See more
Orthologs
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Genomic context

See SPCS1 in Genome Data Viewer
Location:
3p21.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (52706106..52711148)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (52740122..52745164)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene G protein nucleolar 3 Neighboring gene small nucleolar RNA, C/D box 69 Neighboring gene glycosyltransferase 8 domain containing 1 Neighboring gene NIMA related kinase 4 Neighboring gene zinc finger protein 610 pseudogene Neighboring gene adenylate kinase 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Biological insights from 108 schizophrenia-associated genetic loci.
GeneReviews: Not available
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
GeneReviews: Not available
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in protein targeting to ER IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteolysis TAS
Traceable Author Statement
more info
PubMed 
involved_in signal peptide processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in viral protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in virion assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
is_active_in integral component of endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of signal peptidase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of signal peptidase complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
signal peptidase complex subunit 1
Names
SPase 12 kDa subunit
microsomal signal peptidase 12 kDa subunit
signal peptidase 12kDa
signal peptidase complex 12 kDa subunit
signal peptidase complex subunit 1 homolog
NP_054760.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014041.5NP_054760.4  signal peptidase complex subunit 1

    Status: VALIDATED

    Source sequence(s)
    AC104446, AK027426, BC000884, CA309210, DB459917
    Consensus CDS
    CCDS33769.2
    Related
    ENSP00000478310.2, ENST00000619898.5
    Conserved Domains (1) summary
    pfam06645
    Location:1281
    SPC12; Microsomal signal peptidase 12 kDa subunit (SPC12)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    52706106..52711148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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