Format

Send to:

Choose Destination

BZW2 basic leucine zipper and W2 domains 2 [ Homo sapiens (human) ]

Gene ID: 28969, updated on 24-Nov-2020

Summary

Official Symbol
BZW2provided by HGNC
Official Full Name
basic leucine zipper and W2 domains 2provided by HGNC
Primary source
HGNC:HGNC:18808
See related
Ensembl:ENSG00000136261
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MST017; HSPC028; MSTP017
Expression
Broad expression in heart (RPKM 82.0), placenta (RPKM 43.3) and 22 other tissues See more
Orthologs

Genomic context

See BZW2 in Genome Data Viewer
Location:
7p21.1
Exon count:
15
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (16646181..16706522)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (16685759..16746148)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ataxin 2 like pseudogene Neighboring gene uncharacterized LOC105375169 Neighboring gene ankyrin repeat and MYND domain containing 2 Neighboring gene tetraspanin 13 Neighboring gene anterior gradient 2, protein disulphide isomerase family member

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cadherin binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 

General protein information

Preferred Names
basic leucine zipper and W2 domain-containing protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159767.2NP_001153239.1  basic leucine zipper and W2 domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001153239.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 4 encode the same isoform (1).
    Source sequence(s)
    AF083246, BC051898, BC107757
    Consensus CDS
    CCDS5362.1
    UniProtKB/Swiss-Prot
    Q9Y6E2
    UniProtKB/TrEMBL
    A0A024RA42
    Related
    ENSP00000397249.2, ENST00000433922.6
    Conserved Domains (1) summary
    cd11560
    Location:218408
    W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins
  2. NM_001362717.2NP_001349646.1  basic leucine zipper and W2 domain-containing protein 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same isoform (1).
    Source sequence(s)
    AA429958, BC051898, DA566588
    Consensus CDS
    CCDS5362.1
    Conserved Domains (1) summary
    cd11560
    Location:218408
    W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins
  3. NM_001362718.2NP_001349647.1  basic leucine zipper and W2 domain-containing protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' coding region compared to variant 1, resulting in the use of a downstream start codon. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 3 and 5 encode the same isoform (2).
    Source sequence(s)
    AF083246, BC051898
    Conserved Domains (1) summary
    cd11560
    Location:24214
    W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins
  4. NM_001362719.2NP_001349648.1  basic leucine zipper and W2 domain-containing protein 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks an exon in the 5' coding region compared to variant 1, resulting in the use of a downstream start codon. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 3 and 5 encode the same isoform (2).
    Source sequence(s)
    AA429958, BC051898
    Consensus CDS
    CCDS87482.1
    Related
    ENSP00000384617.1, ENST00000407633.1
    Conserved Domains (1) summary
    cd11560
    Location:24214
    W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins
  5. NM_014038.3NP_054757.1  basic leucine zipper and W2 domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_054757.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same isoform (1).
    Source sequence(s)
    AF083246, BC009597
    Consensus CDS
    CCDS5362.1
    UniProtKB/Swiss-Prot
    Q9Y6E2
    UniProtKB/TrEMBL
    A0A024RA42
    Related
    ENSP00000258761.3, ENST00000258761.8
    Conserved Domains (1) summary
    cd11560
    Location:218408
    W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    16646181..16706522
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715708.1XP_006715771.1  basic leucine zipper and W2 domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006715771.1

    UniProtKB/Swiss-Prot
    Q9Y6E2
    UniProtKB/TrEMBL
    A0A024RA42
    Conserved Domains (1) summary
    cd11560
    Location:218408
    W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins
  2. XM_006715707.1XP_006715770.1  basic leucine zipper and W2 domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006715770.1

    UniProtKB/Swiss-Prot
    Q9Y6E2
    UniProtKB/TrEMBL
    A0A024RA42
    Conserved Domains (1) summary
    cd11560
    Location:218408
    W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins
Support Center