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Gba3 glucosylceramidase beta 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289687, updated on 4-Jan-2025

Summary

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Official Symbol
Gba3provided by RGD
Official Full Name
glucosylceramidase beta 3provided by RGD
Primary source
RGD:1309539
See related
EnsemblRapid:ENSRNOG00000024634 AllianceGenome:RGD:1309539
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable hydrolase activity, hydrolyzing O-glycosyl compounds. Predicted to be involved in several processes, including glycosylceramide catabolic process; positive regulation of exo-alpha-sialidase activity; and protein stabilization. Predicted to be located in membrane. Predicted to be part of catalytic complex. Predicted to be active in cytosol. Orthologous to human GBA3 (glucosylceramidase beta 3 (gene/pseudogene)). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward (RPKM 660.0) See more
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Genomic context

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See Gba3 in Genome Data Viewer
Location:
14q11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (64787601..64934043, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (60574974..60721411, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (64390793..64535213, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene rabenosyn, RAB effector, pseudogene 1 Neighboring gene cytochrome c, somatic, pseudogene 3 Neighboring gene uncharacterized LOC134481906 Neighboring gene adhesion G protein-coupled receptor A3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The cytosolic β-glucosidase GBA3 does not influence type 1 Gaucher disease manifestation. Dekker N, et al. Blood Cells Mol Dis, 2011 Jan 15. PMID 20728381
  2. Klotho-related protein is a novel cytosolic neutral beta-glycosylceramidase. Hayashi Y, et al. J Biol Chem, 2007 Oct 19. PMID 17595169
  3. Functional expression of human liver cytosolic beta-glucosidase in Pichia pastoris. Insights into its role in the metabolism of dietary glucosides. Berrin JG, et al. Eur J Biochem, 2002 Jan. PMID 11784319
  4. Cloning and characterization of human liver cytosolic beta-glycosidase. de Graaf M, et al. Biochem J, 2001 Jun 15. PMID 11389701, Free PMC Article
  5. GBA3 promotes fatty acid oxidation and alleviates non-alcoholic fatty liver by increasing CPT2 transcription. Li J, et al. Aging (Albany NY), 2024 Feb 29. PMID 38428407, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GBA3 promotes fatty acid oxidation and alleviates non-alcoholic fatty liver by increasing CPT2 transcription.
    Title: GBA3 promotes fatty acid oxidation and alleviates non-alcoholic fatty liver by increasing CPT2 transcription.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta-galactosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-galactosidase activity ISO
Inferred from Sequence Orthology
more info
  
enables beta-glucosidase activity ISO
Inferred from Sequence Orthology
more info
  
enables galactosylceramidase activity ISO
Inferred from Sequence Orthology
more info
  
enables glucosylceramidase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycosylceramidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosylceramidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in beta-glucoside catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in galactosylceramide catabolic process ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in glucosylceramide catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glucosylceramide catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycoside catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycosylceramide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oligosaccharide catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of exo-alpha-sialidase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of catalytic complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glucosylceramidase beta 3
Names
cytosolic beta-glucosidase
glucosidase, beta, acid 3 (cytosolic)
NP_001382556.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395627.1 → NP_001382556.1  glucosylceramidase beta 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A0G2JVP8, G3V8Y1
    Related
    ENSRNOP00000069571.2, ENSRNOT00000082338.3
    Conserved Domains (1) summary
    cl23725
    Location:4 → 456
    Glyco_hydro; Glycosyl hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    64787601..64934043 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106010.1: Suppressed sequence

    Description
    NM_001106010.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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