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SLC6A16 solute carrier family 6 member 16 [ Homo sapiens (human) ]

Gene ID: 28968, updated on 22-Sep-2022

Summary

Official Symbol
SLC6A16provided by HGNC
Official Full Name
solute carrier family 6 member 16provided by HGNC
Primary source
HGNC:HGNC:13622
See related
Ensembl:ENSG00000063127 MIM:607972; AllianceGenome:HGNC:13622
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NT5; NTT5
Summary
SLC6A16 shows structural characteristics of an Na(+)- and Cl(-)-dependent neurotransmitter transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple N-glycosylation sites.[supplied by OMIM, Mar 2008]
Expression
Biased expression in testis (RPKM 36.6) and ovary (RPKM 1.3) See more
Orthologs
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Genomic context

See SLC6A16 in Genome Data Viewer
Location:
19q13.33
Exon count:
17
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (49289638..49340330, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (52287044..52322619, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49792895..49828448, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985340 Neighboring gene solute carrier family 6 member 21, pseudogene Neighboring gene SUMO1 pseudogene 4 Neighboring gene microRNA 4324 Neighboring gene CD37 molecule Neighboring gene TEA domain transcription factor 2 Neighboring gene uncharacterized LOC101928295 Neighboring gene dickkopf like acrosomal protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables neurotransmitter transmembrane transporter activity NAS
Non-traceable Author Statement
more info
PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in neurotransmitter transport NAS
Non-traceable Author Statement
more info
PubMed 
involved_in nitrogen compound transport IEA
Inferred from Electronic Annotation
more info
 
involved_in organic substance transport IEA
Inferred from Electronic Annotation
more info
 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
orphan sodium- and chloride-dependent neurotransmitter transporter NTT5
Names
CTC-301O7.4
solute carrier family 6 (neurotransmitter transporter), member 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014037.3NP_054756.2  orphan sodium- and chloride-dependent neurotransmitter transporter NTT5

    See identical proteins and their annotated locations for NP_054756.2

    Status: VALIDATED

    Source sequence(s)
    AL136856, AW451672, BG772801
    Consensus CDS
    CCDS42590.1
    UniProtKB/Swiss-Prot
    Q9GZN6, Q9Y5I9
    Related
    ENSP00000338627.3, ENST00000335875.9
    Conserved Domains (1) summary
    cd11502
    Location:103673
    SLC6sbd_NTT5; Neurotransmitter transporter 5; solute-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    49289638..49340330 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438703.1XP_047294659.1  orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 isoform X3

  2. XM_047438702.1XP_047294658.1  orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 isoform X1

  3. XM_011526860.3XP_011525162.1  orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 isoform X4

    Conserved Domains (1) summary
    cd11502
    Location:125695
    SLC6sbd_NTT5; Neurotransmitter transporter 5; solute-binding domain
  4. XM_047438701.1XP_047294657.1  orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 isoform X1

  5. XM_006723168.4XP_006723231.1  orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 isoform X5

    See identical proteins and their annotated locations for XP_006723231.1

    UniProtKB/Swiss-Prot
    Q9GZN6, Q9Y5I9
    Conserved Domains (1) summary
    cd11502
    Location:103673
    SLC6sbd_NTT5; Neurotransmitter transporter 5; solute-binding domain
  6. XM_047438704.1XP_047294660.1  orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 isoform X6

  7. XM_011526859.4XP_011525161.3  orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 isoform X2

  8. XM_024451472.2XP_024307240.1  orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 isoform X5

    UniProtKB/Swiss-Prot
    Q9Y5I9
    Conserved Domains (1) summary
    cd11502
    Location:103673
    SLC6sbd_NTT5; Neurotransmitter transporter 5; solute-binding domain
  9. XM_005258820.4XP_005258877.1  orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 isoform X5

    See identical proteins and their annotated locations for XP_005258877.1

    UniProtKB/Swiss-Prot
    Q9GZN6, Q9Y5I9
    Conserved Domains (1) summary
    cd11502
    Location:103673
    SLC6sbd_NTT5; Neurotransmitter transporter 5; solute-binding domain
  10. XM_011526861.4XP_011525163.1  orphan sodium- and chloride-dependent neurotransmitter transporter NTT5 isoform X6

    Conserved Domains (1) summary
    cd11502
    Location:1526
    SLC6sbd_NTT5; Neurotransmitter transporter 5; solute-binding domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    52287044..52322619 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)