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TMEM176B transmembrane protein 176B [ Homo sapiens (human) ]

Gene ID: 28959, updated on 13-Mar-2020

Summary

Official Symbol
TMEM176Bprovided by HGNC
Official Full Name
transmembrane protein 176Bprovided by HGNC
Primary source
HGNC:HGNC:29596
See related
Ensembl:ENSG00000106565 MIM:610385
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LR8; MS4B2
Expression
Broad expression in liver (RPKM 288.9), kidney (RPKM 126.6) and 16 other tissues See more
Orthologs

Genomic context

See TMEM176B in Genome Data Viewer
Location:
7q36.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (150791287..150801360, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (150488375..150498448, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375566 Neighboring gene Bet1 golgi vesicular membrane trafficking protein pseudogene 1 Neighboring gene transmembrane protein 176A Neighboring gene uncharacterized LOC105375567 Neighboring gene amine oxidase copper containing 1 Neighboring gene VISTA enhancer hs2192 Neighboring gene potassium voltage-gated channel subfamily H member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ26014, MGC110857

Gene Ontology Provided by GOA

Process Evidence Code Pubs
animal organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of dendritic cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 176B
Names
LR8-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101311.1NP_001094781.1  transmembrane protein 176B isoform a

    See identical proteins and their annotated locations for NP_001094781.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same isoform (a).
    Source sequence(s)
    AC006479, AK000841, AK129525, BC091471, BI761752, BI910761
    Consensus CDS
    CCDS5908.1
    UniProtKB/Swiss-Prot
    Q3YBM2
    UniProtKB/TrEMBL
    A0A090N7V7
    Related
    ENSP00000413531.1, ENST00000434545.5
    Conserved Domains (1) summary
    pfam04103
    Location:66229
    CD20; CD20-like family
  2. NM_001101312.2NP_001094782.1  transmembrane protein 176B isoform a

    See identical proteins and their annotated locations for NP_001094782.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same isoform (a).
    Source sequence(s)
    AK000841, AK129525, BC091471, BI761752
    Consensus CDS
    CCDS5908.1
    UniProtKB/Swiss-Prot
    Q3YBM2
    UniProtKB/TrEMBL
    A0A090N7V7
    Related
    ENSP00000318409.5, ENST00000326442.10
    Conserved Domains (1) summary
    pfam04103
    Location:66229
    CD20; CD20-like family
  3. NM_001101314.1NP_001094784.1  transmembrane protein 176B isoform b

    See identical proteins and their annotated locations for NP_001094784.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting protein (isoform b) is shorter than isoform a.
    Source sequence(s)
    AC006479, AK000841, AK129525, BC091471, BI761752
    Consensus CDS
    CCDS47746.1
    UniProtKB/Swiss-Prot
    Q3YBM2
    Related
    ENSP00000404831.2, ENST00000450753.2
    Conserved Domains (1) summary
    pfam04103
    Location:69192
    CD20; CD20-like family
  4. NM_001362691.1NP_001349620.1  transmembrane protein 176B isoform c

    Status: VALIDATED

    Source sequence(s)
    AC006479, AK000841, AK129525, BC091471, BI761752, BI910761, BP370662
    Conserved Domains (1) summary
    pfam04103
    Location:82245
    CD20; CD20-like family
  5. NM_001362692.1NP_001349621.1  transmembrane protein 176B isoform c

    Status: VALIDATED

    Source sequence(s)
    AC006479, AK000841, AK129525, BC091471, BI761752, BP370662
    Conserved Domains (1) summary
    pfam04103
    Location:82245
    CD20; CD20-like family
  6. NM_014020.3NP_054739.3  transmembrane protein 176B isoform a

    See identical proteins and their annotated locations for NP_054739.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a. Variants 1-4 encode the same isoform.
    Source sequence(s)
    AK000841, BC004358, BI759037, BP298052
    Consensus CDS
    CCDS5908.1
    UniProtKB/Swiss-Prot
    Q3YBM2
    UniProtKB/TrEMBL
    A0A090N7V7
    Related
    ENSP00000410269.2, ENST00000447204.6
    Conserved Domains (1) summary
    pfam04103
    Location:66229
    CD20; CD20-like family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    150791287..150801360 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715933.4XP_006715996.2  transmembrane protein 176B isoform X1

    See identical proteins and their annotated locations for XP_006715996.2

    UniProtKB/Swiss-Prot
    Q3YBM2
    Conserved Domains (1) summary
    pfam04103
    Location:69192
    CD20; CD20-like family
  2. XM_024446733.1XP_024302501.1  transmembrane protein 176B isoform X3

    Related
    ENSP00000397810.2, ENST00000429904.6
    Conserved Domains (1) summary
    pfam04103
    Location:66229
    CD20; CD20-like family
  3. XM_024446734.1XP_024302502.1  transmembrane protein 176B isoform X3

    Conserved Domains (1) summary
    pfam04103
    Location:66229
    CD20; CD20-like family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001101313.1: Suppressed sequence

    Description
    NM_001101313.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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