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TMEM176B transmembrane protein 176B [ Homo sapiens (human) ]

Gene ID: 28959, updated on 12-Aug-2022

Summary

Official Symbol
TMEM176Bprovided by HGNC
Official Full Name
transmembrane protein 176Bprovided by HGNC
Primary source
HGNC:HGNC:29596
See related
Ensembl:ENSG00000106565 MIM:610385; AllianceGenome:HGNC:29596
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LR8; MS4B2
Summary
Predicted to be involved in negative regulation of dendritic cell differentiation. Predicted to be located in nuclear membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver (RPKM 288.9), kidney (RPKM 126.6) and 16 other tissues See more
Orthologs
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Genomic context

See TMEM176B in Genome Data Viewer
Location:
7q36.1
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (150791301..150801360, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (151964072..151974120, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (150488389..150498448, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene Bet1 golgi vesicular membrane trafficking protein pseudogene 1 Neighboring gene uncharacterized LOC105375566 Neighboring gene transmembrane protein 176A Neighboring gene uncharacterized LOC105375567 Neighboring gene uncharacterized LOC124901775 Neighboring gene amine oxidase copper containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ26014, MGC110857

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in animal organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in dendritic cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of dendritic cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane protein 176B
Names
LR8-like protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101311.2NP_001094781.1  transmembrane protein 176B isoform a

    See identical proteins and their annotated locations for NP_001094781.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same isoform (a).
    Source sequence(s)
    AK000841, AK129525, BC091471, BI761752, BI910761
    Consensus CDS
    CCDS5908.1
    UniProtKB/Swiss-Prot
    Q3YBM2, Q9Y609
    UniProtKB/TrEMBL
    A0A090N7V7
    Conserved Domains (1) summary
    pfam04103
    Location:66229
    CD20; CD20-like family
  2. NM_001101312.2NP_001094782.1  transmembrane protein 176B isoform a

    See identical proteins and their annotated locations for NP_001094782.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same isoform (a).
    Source sequence(s)
    AK000841, AK129525, BC091471, BI761752
    Consensus CDS
    CCDS5908.1
    UniProtKB/Swiss-Prot
    Q3YBM2, Q9Y609
    UniProtKB/TrEMBL
    A0A090N7V7
    Related
    ENSP00000318409.5, ENST00000326442.10
    Conserved Domains (1) summary
    pfam04103
    Location:66229
    CD20; CD20-like family
  3. NM_001101314.2NP_001094784.1  transmembrane protein 176B isoform b

    See identical proteins and their annotated locations for NP_001094784.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting protein (isoform b) is shorter than isoform a.
    Source sequence(s)
    AK000841, AK129525, BC091471
    Consensus CDS
    CCDS47746.1
    UniProtKB/Swiss-Prot
    Q3YBM2
    Related
    ENSP00000404831.2, ENST00000450753.2
    Conserved Domains (1) summary
    pfam04103
    Location:69192
    CD20; CD20-like family
  4. NM_001362691.2NP_001349620.1  transmembrane protein 176B isoform c

    Status: VALIDATED

    Source sequence(s)
    AK000841, AK129525, BC091471, BI761752, BI910761, BP370662
    Conserved Domains (1) summary
    pfam04103
    Location:82245
    CD20; CD20-like family
  5. NM_001362692.2NP_001349621.1  transmembrane protein 176B isoform c

    Status: VALIDATED

    Source sequence(s)
    AK000841, AK129525, BC091471, BI761752, BP370662
    Conserved Domains (1) summary
    pfam04103
    Location:82245
    CD20; CD20-like family
  6. NM_014020.4NP_054739.3  transmembrane protein 176B isoform a

    See identical proteins and their annotated locations for NP_054739.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a. Variants 1-4 encode the same isoform.
    Source sequence(s)
    AK000841, BC004358, BI759037, BP298052
    Consensus CDS
    CCDS5908.1
    UniProtKB/Swiss-Prot
    Q3YBM2, Q9Y609
    UniProtKB/TrEMBL
    A0A090N7V7
    Related
    ENSP00000410269.2, ENST00000447204.6
    Conserved Domains (1) summary
    pfam04103
    Location:66229
    CD20; CD20-like family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    150791301..150801360 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715933.5XP_006715996.2  transmembrane protein 176B isoform X1

    See identical proteins and their annotated locations for XP_006715996.2

    UniProtKB/Swiss-Prot
    Q3YBM2
    Conserved Domains (1) summary
    pfam04103
    Location:69192
    CD20; CD20-like family
  2. XM_047420259.1XP_047276215.1  transmembrane protein 176B isoform X3

    UniProtKB/Swiss-Prot
    Q9Y609
    UniProtKB/TrEMBL
    A0A090N7V7
  3. XM_047420258.1XP_047276214.1  transmembrane protein 176B isoform X2

  4. XM_024446734.2XP_024302502.1  transmembrane protein 176B isoform X3

    UniProtKB/Swiss-Prot
    Q9Y609
    UniProtKB/TrEMBL
    A0A090N7V7
    Related
    ENSP00000397810.2, ENST00000429904.6
    Conserved Domains (1) summary
    pfam04103
    Location:66229
    CD20; CD20-like family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    151964072..151974120 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001101313.1: Suppressed sequence

    Description
    NM_001101313.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.