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COA3 cytochrome c oxidase assembly factor 3 [ Homo sapiens (human) ]

Gene ID: 28958, updated on 9-Sep-2018

Summary

Official Symbol
COA3provided by HGNC
Official Full Name
cytochrome c oxidase assembly factor 3provided by HGNC
Primary source
HGNC:HGNC:24990
See related
Ensembl:ENSG00000183978 MIM:614775; Vega:OTTHUMG00000180651
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
COX25; CCDC56; HSPC009; MITRAC12
Summary
This gene encodes a member of the cytochrome c oxidase assembly factor family. Studies of a related gene in fly suggest that the encoded protein is localized to mitochondria and is essential for cytochrome c oxidase function. [provided by RefSeq, Nov 2012]
Expression
Ubiquitous expression in kidney (RPKM 59.3), duodenum (RPKM 48.8) and 25 other tissues See more
Orthologs

Genomic context

See COA3 in Genome Data Viewer
Location:
17q21.2
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (42797618..42798725, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40949636..40950743, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 25 homolog Neighboring gene WNK lysine deficient protein kinase 4 Neighboring gene cyclin N-terminal domain containing 1 Neighboring gene beclin 1 Neighboring gene microRNA 6781

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ50764

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
mitochondrial respiratory chain complex IV assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
integral component of mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
cytochrome c oxidase assembly factor 3 homolog, mitochondrial
Names
coiled-coil domain-containing protein 56
cytochrome C oxidase assembly factor 3 homolog, mitochondrial
cytochrome c oxidase assembly protein 3 homolog, mitochondrial
mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 12 kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046771.1 RefSeqGene

    Range
    5001..6108
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001040431.2NP_001035521.1  cytochrome c oxidase assembly factor 3 homolog, mitochondrial

    See identical proteins and their annotated locations for NP_001035521.1

    Status: REVIEWED

    Source sequence(s)
    AC016889, AL524532, AU122748, BC002698
    Consensus CDS
    CCDS32660.1
    UniProtKB/Swiss-Prot
    Q9Y2R0
    UniProtKB/TrEMBL
    A0A024R1X4
    Related
    ENSP00000354762.5, OTTHUMP00000264875, ENST00000328434.7, OTTHUMT00000452397
    Conserved Domains (1) summary
    pfam09813
    Location:991
    Coiled-coil_56; Coiled-coil domain-containing protein 56

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    42797618..42798725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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