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MRPS28 mitochondrial ribosomal protein S28 [ Homo sapiens (human) ]

Gene ID: 28957, updated on 5-Apr-2020


Official Symbol
MRPS28provided by HGNC
Official Full Name
mitochondrial ribosomal protein S28provided by HGNC
Primary source
See related
Ensembl:ENSG00000147586 MIM:611990
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRPS35; HSPC007; MRP-S28; MRP-S35
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has been called mitochondrial ribosomal protein S35 in the literature. [provided by RefSeq, Jul 2008]
Ubiquitous expression in adrenal (RPKM 38.5), heart (RPKM 29.2) and 25 other tissues See more

Genomic context

See MRPS28 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (79918717..80030259, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (80830952..80942516, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927040 Neighboring gene long intergenic non-protein coding RNA 1607 Neighboring gene RNA, U7 small nuclear 85 pseudogene Neighboring gene Sharpr-MPRA regulatory region 4298 Neighboring gene VISTA enhancer hs1305 Neighboring gene tumor protein D52 Neighboring gene uncharacterized LOC105375919 Neighboring gene uncharacterized LOC105375918

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev is identified to have a physical interaction with mitochondrial ribosomal protein S28 (MRPS28) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Potential readthrough

Included gene: TPD52


Clone Names

  • FLJ22853

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
mitochondrial translational elongation TAS
Traceable Author Statement
more info
mitochondrial translational termination TAS
Traceable Author Statement
more info
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
mitochondrial small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
mitochondrial small ribosomal subunit TAS
Traceable Author Statement
more info
mitochondrion IDA
Inferred from Direct Assay
more info

General protein information

Preferred Names
28S ribosomal protein S28, mitochondrial
28S ribosomal protein S35, mitochondrial
mitochondrial 28S ribosomal protein S35
mitochondrial small ribosomal subunit protein bS1m

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014018.3NP_054737.1  28S ribosomal protein S28, mitochondrial

    See identical proteins and their annotated locations for NP_054737.1

    Status: REVIEWED

    Source sequence(s)
    AC036214, BC010150
    Consensus CDS
    ENSP00000276585.4, ENST00000276585.9
    Conserved Domains (1) summary
    MRP-S35; Mitochondrial ribosomal protein MRP-S35

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    79918717..80030259 complement
    GenBank, FASTA, Sequence Viewer (Graphics)
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