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REM1 RRAD and GEM like GTPase 1 [ Homo sapiens (human) ]

Gene ID: 28954, updated on 1-Jun-2020

Summary

Official Symbol
REM1provided by HGNC
Official Full Name
RRAD and GEM like GTPase 1provided by HGNC
Primary source
HGNC:HGNC:15922
See related
Ensembl:ENSG00000088320 MIM:610388
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GES; GD:REM
Summary
The protein encoded by this gene is a GTPase and member of the RAS-like GTP-binding protein family. The encoded protein is expressed in endothelial cells, where it promotes reorganization of the actin cytoskeleton and morphological changes in the cells. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 3.0), endometrium (RPKM 2.6) and 21 other tissues See more
Orthologs

Genomic context

See REM1 in Genome Data Viewer
Location:
20q11.21
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (31475273..31484895)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (30063091..30072708)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene defensin beta 123 Neighboring gene defensin beta 124 Neighboring gene long intergenic non-protein coding RNA 28 Neighboring gene tRNA-Ser (anticodon AGA) 7-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC48669

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
calcium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of high voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
GTP-binding protein REM 1
Names
GTPase-regulating endothelial cell sprouting
RAS (RAD and GEM)-like GTP-binding 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046939.1 RefSeqGene

    Range
    5001..14608
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014012.6NP_054731.2  GTP-binding protein REM 1

    See identical proteins and their annotated locations for NP_054731.2

    Status: REVIEWED

    Source sequence(s)
    AF152863, AK313060
    Consensus CDS
    CCDS13181.1
    UniProtKB/Swiss-Prot
    O75628
    Related
    ENSP00000201979.2, ENST00000201979.3
    Conserved Domains (2) summary
    smart00010
    Location:81237
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
    cd04148
    Location:81298
    RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    31475273..31484895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027833.1XP_016883322.1  GTP-binding protein REM 1 isoform X1

    Conserved Domains (2) summary
    smart00010
    Location:81245
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
    cd04148
    Location:81306
    RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases
  2. XM_005260404.1XP_005260461.1  GTP-binding protein REM 1 isoform X1

    Conserved Domains (2) summary
    smart00010
    Location:81245
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
    cd04148
    Location:81306
    RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases
  3. XM_011528795.1XP_011527097.1  GTP-binding protein REM 1 isoform X2

    Conserved Domains (2) summary
    smart00010
    Location:81243
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
    cd04148
    Location:81304
    RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases
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