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TRIB2 tribbles pseudokinase 2 [ Homo sapiens (human) ]

Gene ID: 28951, updated on 18-Sep-2024

Summary

Official Symbol
TRIB2provided by HGNC
Official Full Name
tribbles pseudokinase 2provided by HGNC
Primary source
HGNC:HGNC:30809
See related
Ensembl:ENSG00000071575 MIM:609462; AllianceGenome:HGNC:30809
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C5FW; TRB2; GS3955
Summary
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
Expression
Ubiquitous expression in ovary (RPKM 31.3), spleen (RPKM 27.6) and 24 other tissues See more
Orthologs
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Genomic context

See TRIB2 in Genome Data Viewer
Location:
2p24.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (12716936..12742734)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (12746001..12771799)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (12857062..12882860)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene MIR3681 host gene Neighboring gene uncharacterized LOC107985853 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15339 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11181 Neighboring gene NANOG hESC enhancer GRCh37_chr2:12714950-12715488 Neighboring gene MPRA-validated peak3595 silencer Neighboring gene Sharpr-MPRA regulatory region 12883 Neighboring gene MPRA-validated peak3596 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:12766335-12766899 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:12804005-12804220 Neighboring gene uncharacterized LOC124905974 Neighboring gene CRISPRi-validated cis-regulatory element chr2.599 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:12856972-12857611 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11182 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:12858891-12859528 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:12866409-12867608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15342 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:12909653-12910503 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:12956433-12957632 Neighboring gene microRNA 3125 Neighboring gene CRISPR/Cas9-targeted silencer 9 Neighboring gene uncharacterized LOC100506474 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:13120952-13121455 Neighboring gene uncharacterized LOC105373436 Neighboring gene uncharacterized LOC105373484

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association of pericardial fat identifies a unique locus for ectopic fat.
EBI GWAS Catalog
GWAS of dental caries patterns in the permanent dentition.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ57420

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables mitogen-activated protein kinase kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
NOT enables nucleotide binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables ubiquitin-protein transferase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011644.1 RefSeqGene

    Range
    5065..30863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_021643.4NP_067675.1  tribbles homolog 2

    See identical proteins and their annotated locations for NP_067675.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes a functional protein.
    Source sequence(s)
    AC009486
    Consensus CDS
    CCDS1683.1
    UniProtKB/Swiss-Prot
    B2R851, D6W510, Q92519
    Related
    ENSP00000155926.4, ENST00000155926.9
    Conserved Domains (1) summary
    cd14022
    Location:67308
    PK_TRB2; Pseudokinase domain of Tribbles Homolog 2

RNA

  1. NR_027303.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and lacks the translational start codon used in variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC009486, AK129973, AK299146, AY245544, D87119
    Related
    ENST00000381465.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    12716936..12742734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    12746001..12771799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)