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TRIB2 tribbles pseudokinase 2 [ Homo sapiens (human) ]

Gene ID: 28951, updated on 14-Jun-2020

Summary

Official Symbol
TRIB2provided by HGNC
Official Full Name
tribbles pseudokinase 2provided by HGNC
Primary source
HGNC:HGNC:30809
See related
Ensembl:ENSG00000071575 MIM:609462
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C5FW; TRB2; GS3955
Summary
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
Expression
Ubiquitous expression in ovary (RPKM 31.3), spleen (RPKM 27.6) and 24 other tissues See more
Orthologs

Genomic context

See TRIB2 in Genome Data Viewer
Location:
2p24.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (12716872..12742734)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (12856998..12882860)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene MIR3681 host gene Neighboring gene uncharacterized LOC107985853 Neighboring gene CRISPRi-validated cis-regulatory element chr2.599 Neighboring gene microRNA 3125 Neighboring gene uncharacterized LOC100506474 Neighboring gene uncharacterized LOC105373436 Neighboring gene uncharacterized LOC105373484

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association of pericardial fat identifies a unique locus for ectopic fat.
NHGRI GWA Catalog
GWAS of dental caries patterns in the permanent dentition.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ57420

Gene Ontology Provided by GOA

Function Evidence Code Pubs
mitogen-activated protein kinase kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT nucleotide binding ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
ubiquitin protein ligase binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
ubiquitin-protein transferase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
negative regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of interleukin-10 biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
NOT protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of MAP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011644.1 RefSeqGene

    Range
    5001..30863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_021643.3NP_067675.1  tribbles homolog 2

    See identical proteins and their annotated locations for NP_067675.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes a functional protein.
    Source sequence(s)
    AC009486, AY245544, DC379987
    Consensus CDS
    CCDS1683.1
    UniProtKB/Swiss-Prot
    Q92519
    Related
    ENSP00000155926.4, ENST00000155926.8
    Conserved Domains (1) summary
    cd14022
    Location:67308
    PK_TRB2; Pseudokinase domain of Tribbles Homolog 2

RNA

  1. NR_027303.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and lacks the translational start codon used in variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC009486, AK129973, AK299146, AY245544, D87119
    Related
    ENST00000381465.2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    12716872..12742734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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