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Xpr1 xenotropic and polytropic retrovirus receptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289424, updated on 11-Apr-2024

Summary

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Symbol
Xpr1provided by RGD
Full Name
xenotropic and polytropic retrovirus receptor 1provided by RGD
Primary source
RGD:1306554
See related
Ensembl:ENSRNOG00000000042 AllianceGenome:RGD:1306554
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
SLC53A1
Summary
Predicted to enable several functions, including inositol hexakisphosphate binding activity; phosphate ion transmembrane transporter activity; and virus receptor activity. Predicted to be involved in cellular phosphate ion homeostasis; cellular response to phosphate starvation; and phosphate ion transmembrane transport. Predicted to act upstream of or within response to virus. Predicted to be intrinsic component of plasma membrane. Predicted to be active in Golgi apparatus and plasma membrane. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human XPR1 (xenotropic and polytropic retrovirus receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 119.5), Brain (RPKM 89.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
13q21
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (69991517..70136249, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (67441205..67585950, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (72918552..73056785, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene syntaxin 6 Neighboring gene KIAA1614 homolog Neighboring gene uncharacterized LOC102553685 Neighboring gene ribosomal protein S17 like 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Inorganic phosphate export by the retrovirus receptor XPR1 in metazoans. Giovannini D, et al. Cell Rep, 2013 Jun 27. PMID 23791524
  2. Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains. Wild R, et al. Science, 2016 May 20. PMID 27080106
  3. Receptors for polytropic and xenotropic mouse leukaemia viruses encoded by a single gene at Rmc1. Yang YL, et al. Nat Genet, 1999 Feb. PMID 9988277
  4. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Olsen JV, et al. Sci Signal, 2010 Jan 12. PMID 20068231
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables efflux transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol hexakisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol hexakisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables virus receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to phosphate starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular phosphate ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphate ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphate ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in symbiont entry into host cell IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
solute carrier family 53 member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105992.1 → NP_001099462.1  solute carrier family 53 member 1

    See identical proteins and their annotated locations for NP_001099462.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473958
    UniProtKB/TrEMBL
    A0A8I6ABE7, A6ICY8
    Related
    ENSRNOP00000000049.5, ENSRNOT00000000049.7
    Conserved Domains (2) summary
    cd14477
    Location:2 → 165
    SPX_XPR1_like; SPX domain of the xenotropic and polytropic retrovirus receptor 1 (XPR1) and related proteins
    pfam03124
    Location:268 → 617
    EXS; EXS family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    69991517..70136249 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090615.2 → XP_038946543.1  solute carrier family 53 member 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JXZ7, A0A8I6GL93
    Related
    ENSRNOP00000095690.1
    Conserved Domains (2) summary
    cd14477
    Location:2 → 143
    SPX_XPR1_like; SPX domain of the xenotropic and polytropic retrovirus receptor 1 (XPR1) and related proteins
    pfam03124
    Location:246 → 595
    EXS; EXS family
Nucleotide Protein Strain
Heading Accession and Version

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