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Nit1 nitrilase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289222, updated on 12-Aug-2018

Summary

Official Symbol
Nit1provided by RGD
Official Full Name
nitrilase 1provided by RGD
Primary source
RGD:727821
See related
Ensembl:ENSRNOG00000003881
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
The protein encoded by this gene is a member of the nitrilase enzyme superfamily. Nitrilases are nonpeptidic C-N hydrolases. In mammals, nitrilases form small molecule C-N bonds such as acid amides, carbamates and ureas. Nit1-deficient mice display phenotypes including increased cell proliferation, resistance to DNA damage, and an increased number of N-nitrosomethylbenzylamine-induced murine forestomach tumors, suggesting a tumor suppressor function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
Expression
Biased expression in Kidney (RPKM 940.4), Adrenal (RPKM 606.4) and 9 other tissues See more
Orthologs

Genomic context

See Nit1 in Genome Data Viewer
Location:
13q24
Exon count:
8
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (89722370..89725806, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 13 NC_005112.3 (94349703..94353139, complement)

Chromosome 13 - NC_005112.4Genomic Context describing neighboring genes Neighboring gene guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like Neighboring gene death effector domain-containing Neighboring gene prefoldin subunit 2 Neighboring gene kelch domain containing 9 Neighboring gene nectin cell adhesion molecule 4

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Homology

Clone Names

  • MGC95151

Gene Ontology Provided by RGD

Function Evidence Code Pubs
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
nitrogen compound metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
deaminated glutathione amidase
Names
dGSH amidase
nitrilase homolog 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082580.1NP_001076049.1  deaminated glutathione amidase isoform b

    See identical proteins and their annotated locations for NP_001076049.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the 5' coding region, which results in initiation of translation from a downstream start codon compared to variant 1. It encodes isoform b, which has a shorter N-terminus compared to isoform a. Variants 2 and 4 encode the same isoform.
    Source sequence(s)
    AC099236, BC087146, FM045849
    UniProtKB/Swiss-Prot
    Q7TQ94
    Related
    ENSRNOP00000005194.5, ENSRNOT00000005194.5
    Conserved Domains (1) summary
    cd07572
    Location:13280
    nit; Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases)
  2. NM_001305646.1NP_001292575.1  deaminated glutathione amidase isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. It encodes isoform c, which is shorter than isoform a.
    Source sequence(s)
    AC099236, BC087146
    UniProtKB/Swiss-Prot
    Q7TQ94
    Conserved Domains (1) summary
    cd07572
    Location:43310
    nit; Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases)
  3. NM_001305647.1NP_001292576.1  deaminated glutathione amidase isoform b

    See identical proteins and their annotated locations for NP_001292576.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses a downstream start codon compared to variant 1. It encodes isoform b, which has a shorter N-terminus than isoform a. Variants 2 and 4 encode the same isoform.
    Source sequence(s)
    BC087146, CV073582
    UniProtKB/Swiss-Prot
    Q7TQ94
    Conserved Domains (1) summary
    cd07572
    Location:13280
    nit; Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases)
  4. NM_182668.2NP_872609.2  deaminated glutathione amidase isoform a

    See identical proteins and their annotated locations for NP_872609.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC099236, BC087146
    UniProtKB/Swiss-Prot
    Q7TQ94
    Conserved Domains (1) summary
    cd07572
    Location:49316
    nit; Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005112.4 Reference Rnor_6.0 Primary Assembly

    Range
    89722370..89725806 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000081.1 Alternate Rn_Celera

    Range
    83400571..83404007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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