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Creg1 cellular repressor of E1A-stimulated genes 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 289185, updated on 3-Jun-2026
Official Symbol
Creg1provided by RGD
Official Full Name
cellular repressor of E1A-stimulated genes 1provided by RGD
Primary source
RGD:1306804
See related
AllianceGenome:RGD:1306804
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Creg
Summary
Predicted to act upstream of or within several processes, including endocytosis; lysosomal lumen acidification; and regulation of DNA-templated transcription. Predicted to be located in endosome and lysosome. Predicted to be part of transcription regulator complex. Predicted to be active in extracellular space. Orthologous to human CREG1 (cellular repressor of E1A stimulated genes 1). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Liver (RPKM 504.6), Spleen (RPKM 329.2) and 9 other tissues See more
Orthologs
all
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See Creg1 in Genome Data Viewer
Location:
13q23
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (80552779..80565272)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (78019814..78032310)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (83972186..83984675)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096304 Neighboring gene uncharacterized LOC120096305 Neighboring gene Cd247 molecule Neighboring gene POU class 2 homeobox 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. CREG improves cardiac function by regulating cardiomyocytes' autophagy in diabetic myocardial infarction rats. Tai TT, et al. Eur Rev Med Pharmacol Sci, 2020 Nov. PMID 33215442
  2. Recombinant Cellular Repressor of E1A-Stimulated Genes Protects against Renal Fibrosis in Dahl Salt-Sensitive Rats. Liu ML, et al. Am J Nephrol, 2020. PMID 32320986
  3. Antiapoptotic role of the cellular repressor of E1A-stimulated genes (CREG) in retinal photoreceptor cells in a rat model of light-induced retinal injury. Zhang TZ, et al. Biomed Pharmacother, 2018 Jul. PMID 29864918
  4. Overexpression of cellular repressor of E1A-stimulated genes inhibits TNF-α-induced apoptosis via NF-κB in mesenchymal stem cells. Peng CF, et al. Biochem Biophys Res Commun, 2011 Mar 25. PMID 21354106
  5. Cellular Repressor of E1A-Stimulated Genes Is a Critical Determinant of Vascular Remodeling in Response to Angiotensin II. Li Y, et al. Arterioscler Thromb Vasc Biol, 2017 Mar. PMID 28062494

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CREG improves cardiac function by regulating cardiomyocytes' autophagy in diabetic myocardial infarction rats.
    Title: CREG improves cardiac function by regulating cardiomyocytes' autophagy in diabetic myocardial infarction rats.
  2. Recombinant Cellular Repressor of E1A-Stimulated Genes Protects against Renal Fibrosis in Dahl Salt-Sensitive Rats.
    Title: Recombinant Cellular Repressor of E1A-Stimulated Genes Protects against Renal Fibrosis in Dahl Salt-Sensitive Rats.
  3. CREG protected retinal cells against apoptosis by inhibiting P38/MAPK and JNK/MAPK signaling pathways and activating the PI3K-AKT signaling pathway.
    Title: Antiapoptotic role of the cellular repressor of E1A-stimulated genes (CREG) in retinal photoreceptor cells in a rat model of light-induced retinal injury.
  4. CREG is a novel mediator of vascular remodeling in response to Ang II.
    Title: Cellular Repressor of E1A-Stimulated Genes Is a Critical Determinant of Vascular Remodeling in Response to Angiotensin II.
  5. The results of this study indicate that CREG acts as a novel and potent survival factor in mesenchymal stem cells.
    Title: Overexpression of cellular repressor of E1A-stimulated genes inhibits TNF-α-induced apoptosis via NF-κB in mesenchymal stem cells.
  6. This study indicates that CREG is a novel and potent survival factor for mesenchymal stem cells.
    Title: Overexpressing cellular repressor of E1A-stimulated genes protects mesenchymal stem cells against hypoxia- and serum deprivation-induced apoptosis by activation of PI3K/Akt.
  7. CREG was found to inhibit cardiac cell growth as a novel regulator of ERK1/2 and might participate in the development of cardiac hypertrophy under pressure overload
    Title: CREG, a new regulator of ERK1/2 in cardiac hypertrophy.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables insulin-like growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within autophagy ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within endocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lysosomal lumen acidification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lysosome organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
protein CREG1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105966.1 → NP_001099436.1  protein CREG1 precursor

    See identical proteins and their annotated locations for NP_001099436.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473958
    UniProtKB/TrEMBL
    F7FH64
    Conserved Domains (1) summary
    pfam13883
    Location:50 → 216
    Pyrid_oxidase_2; Pyridoxamine 5'-phosphate oxidase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    80552779..80565272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008769625.4 → XP_008767847.2  protein CREG1 isoform X1

    UniProtKB/TrEMBL
    F7FH64
    Conserved Domains (1) summary
    pfam13883
    Location:50 → 216
    Pyrid_oxidase_2; Pyridoxamine 5'-phosphate oxidase
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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