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DFR1 dihydrofolate reductase [ Nakaseomyces glabratus ]

Gene ID: 2889661, updated on 16-Jun-2026
Gene symbol
DFR1
Gene description
dihydrofolate reductase
Locus tag
GVI51_J03729
See related
FungiDB:GVI51_J03729; VEuPathDB:GVI51_J03729
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Nakaseomyces glabratus (strain: ATCC 2001, nat-host: Homo sapiens, culture-collection: ATCC:2001, type-material: type material of Cryptococcus glabratus)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Nakaseomyces
Orthologs
all
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See DFR1 in Genome Data Viewer
Location:
chromosome: J
Exon count:
1
Sequence:
Chromosome: J; NC_088960.1 (391390..392043)

Chromosome J - NC_088960.1Genomic Context describing neighboring genes Neighboring gene mitochondrial nucleotide exchange factor MGE1 Neighboring gene putative serine/threonine protein kinase KIN4 Neighboring gene oxysterol-binding protein related protein HES1 Neighboring gene uncharacterized protein

Genomic Sequence:
NC_088960.1

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. De novo genome assembly of Candida glabrata reveals cell wall protein complement and structure of dispersed tandem repeat arrays. Xu Z, et al. Mol Microbiol, 2020 Jun. PMID 32068314
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Homology

  • CAGL0J03894g
    Ortholog(s) have dihydrofolate reductase activity, drug binding, mRNA binding activity, role in dihydrofolate metabolic process, tetrahydrofolate biosynthetic process and mitochondrion localization

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables NADP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables dihydrofolate reductase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in dihydrofolate metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in folic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glycine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tetrahydrofolate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
dihydrofolate reductase
XP_447874.1
  • CAGL0J03894g
    Ortholog(s) have dihydrofolate reductase activity, drug binding, mRNA binding activity, role in dihydrofolate metabolic process, tetrahydrofolate biosynthetic process and mitochondrion localization

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_088960.1 Reference assembly

    Range
    391390..392043
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_447874.1 → XP_447874.1  dihydrofolate reductase GVI51_J03729

    See identical proteins and their annotated locations for XP_447874.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    Q6FPH0
    Conserved Domains (1) summary
    cd00209
    Location:9 → 157
    DHFR; Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5, ...
Nucleotide Protein
Heading Accession and Version

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