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Dhps deoxyhypusine synthase [ Rattus norvegicus (Norway rat) ]

Gene ID: 288923, updated on 2-Oct-2018

Summary

Official Symbol
Dhpsprovided by RGD
Official Full Name
deoxyhypusine synthaseprovided by RGD
Primary source
RGD:1303326
See related
Ensembl:ENSRNOG00000004219
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
human homolog catalyzes the first step in the post-translational modification of a lysine residue in the precursor eukaryotic initiation factor 5A (eIF5A) to the amino acid hypusine [RGD, Feb 2006]
Expression
Biased expression in Heart (RPKM 195.8), Muscle (RPKM 182.1) and 9 other tissues See more
Orthologs

Genomic context

See Dhps in Genome Data Viewer
Location:
19q11
Exon count:
9
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (26184665..26188755)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 19 NC_005118.3 (37160288..37164378)

Chromosome 19 - NC_005118.4Genomic Context describing neighboring genes Neighboring gene F-box and WD repeat domain containing 9 Neighboring gene G protein subunit gamma 14 Neighboring gene WD repeat domain 83 Neighboring gene WD repeat domain 83 opposite strand Neighboring gene mannosidase, alpha, class 2B, member 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • MGC94237

Gene Ontology Provided by RGD

Function Evidence Code Pubs
deoxyhypusine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
deoxyhypusine synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
deoxyhypusine synthase activity ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
peptidyl-lysine modification to peptidyl-hypusine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-lysine modification to peptidyl-hypusine ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
protein homotetramerization IDA
Inferred from Direct Assay
more info
PubMed 
spermidine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
spermidine metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
deoxyhypusine synthase
Names
DHS
NP_001004207.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004207.1NP_001004207.1  deoxyhypusine synthase

    See identical proteins and their annotated locations for NP_001004207.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079188
    UniProtKB/Swiss-Prot
    Q6AY53
    Related
    ENSRNOP00000005656.3, ENSRNOT00000005656.5
    Conserved Domains (1) summary
    pfam01916
    Location:45351
    DS; Deoxyhypusine synthase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005118.4 Reference Rnor_6.0 Primary Assembly

    Range
    26184665..26188755
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000087.1 Alternate Rn_Celera

    Range
    22640425..22644511 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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