Farsa phenylalanyl-tRNA synthetase subunit alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Farsaprovided by RGD
Official Full Name: phenylalanyl-tRNA synthetase subunit alphaprovided by RGD
Primary source: RGD:1310314
See related: Ensembl:ENSRNOG00000003149 AllianceGenome:RGD:1310314
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Farsla
Summary: Predicted to enable phenylalanine-tRNA ligase activity. Predicted to be involved in phenylalanyl-tRNA aminoacylation and protein heterotetramerization. Located in cytoplasm. Orthologous to human FARSA (phenylalanyl-tRNA synthetase subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 213.8), Adrenal (RPKM 165.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q11

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (40196255..40205830, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (23291409..23300985, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (25969255..25978777)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phenylalanine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phenylalanine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables phenylalanine-tRNA ligase activity	ISO Inferred from Sequence Orthology more info
enables phenylalanine-tRNA ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in phenylalanyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phenylalanyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in phenylalanyl-tRNA aminoacylation	ISO Inferred from Sequence Orthology more info
involved_in phenylalanyl-tRNA aminoacylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein heterotetramerization	IEA Inferred from Electronic Annotation more info
involved_in protein heterotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein heterotetramerization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of phenylalanine-tRNA ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of phenylalanine-tRNA ligase complex	IEA Inferred from Electronic Annotation more info
part_of phenylalanine-tRNA ligase complex	ISO Inferred from Sequence Orthology more info
part_of phenylalanine-tRNA ligase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: phenylalanine--tRNA ligase alpha subunit

Names: pheRS; phenylalanine--tRNA ligase alpha chain; phenylalanine-tRNA synthetase-like, alpha subunit; phenylalanyl-tRNA synthetase alpha chain; phenylalanyl-tRNA synthetase, alpha subunit

NP_001019408.1

EC 6.1.1.20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.