Rilpl2 Rab interacting lysosomal protein-like 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rilpl2provided by RGD
Official Full Name: Rab interacting lysosomal protein-like 2provided by RGD
Primary source: RGD:1303140
See related: Ensembl:ENSRNOG00000001061 AllianceGenome:RGD:1303140
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable dynein light intermediate chain binding activity; identical protein binding activity; and small GTPase binding activity. Predicted to be involved in cilium assembly; epithelial cell morphogenesis; and protein transport from ciliary membrane to plasma membrane. Predicted to be located in several cellular components, including centrosome; cilium; and cytosol. Predicted to be active in ciliary basal body and cytoplasm. Orthologous to human RILPL2 (Rab interacting lysosomal protein like 2). [provided by Alliance of Genome Resources, Apr 2025]
Expression: Biased expression in Adrenal (RPKM 223.0), Spleen (RPKM 197.9) and 9 other tissues See more
Orthologs: all
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Genomic context

Location:: 12q15

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (37786877..37798412)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (32125908..32137426)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (37544918..37556453)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data represent a novel mechanism linking RILPL2, the motor protein MyoVa and Rac1 with neuronal structure and function.
Title: Myosin-Va-interacting protein, RILPL2, controls cell shape and neuronal morphogenesis via Rac signaling.

Submit: New GeneRIF Correction

General gene information

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Markers

RH142826 (e-PCR)
- UniSTS:232073

D12Rat107 (e-PCR), detects polymorphism
- UniSTS:226448

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dynein light intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelial cell morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport from ciliary membrane to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in protein transport from ciliary membrane to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein transport from ciliary membrane to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in cilium	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: RILP-like protein 2

Names: rab-interacting lysosomal-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004205.1 → NP_001004205.1 RILP-like protein 2

See identical proteins and their annotated locations for NP_001004205.1

Status: PROVISIONAL

Source sequence(s)

BC079132

UniProtKB/Swiss-Prot

Q6AYA0

UniProtKB/TrEMBL

A0A8I6AQ16, A6J0Z6

Related

ENSRNOP00000001403.4, ENSRNOT00000001403.6

Conserved Domains (2) summary

cd14445
Location:18 → 95

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

pfam11461
Location:124 → 180

RILP; Rab interacting lysosomal protein