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Dhrsx dehydrogenase/reductase X-linked [ Rattus norvegicus (Norway rat) ]

Gene ID: 288525, updated on 30-Jul-2025
Official Symbol
Dhrsxprovided by RGD
Official Full Name
dehydrogenase/reductase X-linkedprovided by RGD
Primary source
RGD:1305017
See related
Ensembl:ENSRNOG00000028323 AllianceGenome:RGD:1305017
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable dolichal reductase [NAD(P)+] activity and polyprenol dehydrogenase activity. Predicted to be involved in dolichol biosynthetic process and positive regulation of autophagy. Predicted to be active in extracellular region and lipid droplet. Orthologous to human DHRSX (dehydrogenase/reductase X-linked). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Adrenal (RPKM 105.2), Thymus (RPKM 94.6) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table
See Dhrsx in Genome Data Viewer
Location:
12q11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (21413563..21418319)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (16299768..16304553)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (18516858..18521235)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 157 Neighboring gene uncharacterized LOC134481271 Neighboring gene olfactory receptor family 7 subfamily A member 43, pseudogene 1 Neighboring gene acetylserotonin O-methyltransferase Neighboring gene A-kinase anchoring protein 17A

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. DHRSX, a novel non-classical secretory protein associated with starvation induced autophagy. Zhang G, et al. Int J Med Sci, 2014. PMID 25076851, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables dolichal reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables polyprenol dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
  
is_active_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
dehydrogenase/reductase SDR family member on chromosome X
Names
dehydrogenase/reductase (SDR family) X chromosome
dehydrogenase/reductase (SDR family) X-linked

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105914.2 → NP_001099384.2  dehydrogenase/reductase SDR family member on chromosome X isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A6K200

  2. NM_001400919.1 → NP_001387848.1  dehydrogenase/reductase SDR family member on chromosome X isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A0A8J8YGQ6, B2RZ76, E9PTT7
    Related
    ENSRNOP00000031241.7, ENSRNOT00000029485.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    21413563..21418319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248995.5 → XP_006249057.1  dehydrogenase/reductase SDR family member on chromosome X isoform X2

    Conserved Domains (1) summary
    cl21454
    Location:41 → 187
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. XM_039089192.2 → XP_038945120.1  dehydrogenase/reductase SDR family member on chromosome X isoform X4

    Conserved Domains (1) summary
    cl21454
    Location:41 → 187
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  3. XM_017598292.3 → XP_017453781.1  dehydrogenase/reductase SDR family member on chromosome X isoform X1

    UniProtKB/TrEMBL
    B2RZ76, E9PTT7

  4. XM_063271142.1 → XP_063127212.1  dehydrogenase/reductase SDR family member on chromosome X isoform X3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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