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GRB2 growth factor receptor bound protein 2 [ Homo sapiens (human) ]

Gene ID: 2885, updated on 21-Dec-2019

Summary

Official Symbol
GRB2provided by HGNC
Official Full Name
growth factor receptor bound protein 2provided by HGNC
Primary source
HGNC:HGNC:4566
See related
Ensembl:ENSG00000177885 MIM:108355
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ASH; Grb3-3; MST084; NCKAP2; MSTP084; EGFRBP-GRB2
Summary
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 63.6), appendix (RPKM 60.2) and 25 other tissues See more
Orthologs

Genomic context

See GRB2 in Genome Data Viewer
Location:
17q25.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (75318076..75405709, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73314157..73401790, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100287042 Neighboring gene mitochondrial ribosomal protein S7 Neighboring gene MIF4G domain containing Neighboring gene solute carrier family 25 member 19 Neighboring gene ribosomal protein L36a pseudogene 7 Neighboring gene RNA, U6 small nuclear 938, pseudogene Neighboring gene microRNA 3678

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef Grb3-3, an isoform of Grb2, is upregulated by HIV-1 Nef protein and potentiates HIV-1 LTR promoter activity PubMed
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with growth factor receptor-bound protein 2 (GRB2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Tat tat Grb3-3, an isoform of Grb2, is upregulated by HIV-1 Tat protein and potentiates HIV-1 LTR promoter activity PubMed
tat The binding between HIV-1 Tat and Grb2 is mediated by the proline-rich sequence (residues 1-18) of Tat and the SH3 domain (residues 160-212) of Grb2, which impairs activation of the Raf/MAPK pathway and increases the PKA/Raf inhibitory pathway PubMed
tat HIV-1 Tat-induced small GTPase Ras activation is mediated by tyrosine phosphorylation of Shc and recruitment of Grb2 in human endothelial cells PubMed
reverse transcriptase gag-pol HIV-1 RT is identified to have a physical interaction with growth factor receptor-bound protein 2 (GRB2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
SH3 domain binding IDA
Inferred from Direct Assay
more info
PubMed 
SH3/SH2 adaptor activity TAS
Traceable Author Statement
more info
PubMed 
ephrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
epidermal growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
insulin receptor substrate binding IPI
Inferred from Physical Interaction
more info
PubMed 
neurotrophin TRKA receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphotyrosine residue binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ERBB2 signaling pathway TAS
Traceable Author Statement
more info
 
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
MAPK cascade TAS
Traceable Author Statement
more info
 
Ras protein signal transduction TAS
Traceable Author Statement
more info
PubMed 
T cell costimulation TAS
Traceable Author Statement
more info
 
aging IEA
Inferred from Electronic Annotation
more info
 
anatomical structure formation involved in morphogenesis IEA
Inferred from Electronic Annotation
more info
 
axon guidance TAS
Traceable Author Statement
more info
 
branching involved in labyrinthine layer morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
cellular response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
entry of bacterium into host cell TAS
Traceable Author Statement
more info
 
epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
insulin receptor signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
insulin receptor signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-15-mediated signaling pathway TAS
Traceable Author Statement
more info
 
leukocyte migration TAS
Traceable Author Statement
more info
 
membrane organization TAS
Traceable Author Statement
more info
 
negative regulation of epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
neurotrophin TRK receptor signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of Ras protein signal transduction TAS
Traceable Author Statement
more info
 
positive regulation of actin filament polymerization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase B signaling TAS
Traceable Author Statement
more info
 
positive regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein heterooligomerization IEA
Inferred from Electronic Annotation
more info
 
receptor internalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
signal transduction in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
COP9 signalosome IDA
Inferred from Direct Assay
more info
PubMed 
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
Grb2-EGFR complex IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
vesicle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
growth factor receptor-bound protein 2
Names
HT027
SH2/SH3 adapter GRB2
abundant SRC homology
epidermal growth factor receptor-binding protein GRB2
epididymis secretory sperm binding protein
growth factor receptor-bound protein 3
protein Ash

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029556.1 RefSeqGene

    Range
    5001..92634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002086.5NP_002077.1  growth factor receptor-bound protein 2 isoform 1

    See identical proteins and their annotated locations for NP_002077.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC011933
    Consensus CDS
    CCDS11721.1
    UniProtKB/Swiss-Prot
    P62993
    UniProtKB/TrEMBL
    B0LPF3
    Related
    ENSP00000339007.4, ENST00000316804.10
    Conserved Domains (3) summary
    cd09941
    Location:56150
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11946
    Location:156
    SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
    cd11949
    Location:160212
    SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
  2. NM_203506.2NP_987102.1  growth factor receptor-bound protein 2 isoform 2

    See identical proteins and their annotated locations for NP_987102.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, as compared to variant 1. It encodes the shorter isoform (2) that lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AC011933, BC000631, DA458680
    Consensus CDS
    CCDS11722.1
    UniProtKB/Swiss-Prot
    P62993
    Related
    ENSP00000317360.5, ENST00000316615.9
    Conserved Domains (2) summary
    cd09941
    Location:15109
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11949
    Location:119171
    SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    75318076..75405709 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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