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Trrap transformation/transcription domain-associated protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 288471, updated on 8-Apr-2026
Official Symbol
Trrapprovided by RGD
Official Full Name
transformation/transcription domain-associated proteinprovided by RGD
Primary source
RGD:1305446
See related
Ensembl:ENSRNOG00000025244 AllianceGenome:RGD:1305446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables chromatin binding activity. Predicted to be involved in positive regulation of double-strand break repair via homologous recombination; regulation of cell cycle; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be part of chromatin. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 75. Orthologous to human TRRAP (transformation/transcription domain associated protein). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Adrenal (RPKM 261.4), Spleen (RPKM 152.8) and 9 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Trrap in Genome Data Viewer
Location:
12p11
Exon count:
74
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (14851758..14941444, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (9738006..9827708, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (11537950..11627563, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene karyopherin subunit alpha 7 Neighboring gene SMAD specific E3 ubiquitin protein ligase 1 Neighboring gene uncharacterized LOC134481264 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene small nucleolar RNA ZL1 Neighboring gene transmembrane protein 130 Neighboring gene transfer RNA serine (anticodon AGA) 12

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression. Herceg Z, et al. Nat Genet, 2001 Oct. PMID 11544477
  2. Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation. Frank SR, et al. Genes Dev, 2001 Aug 15. PMID 11511539, Free PMC Article
  3. The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. McMahon SB, et al. Cell, 1998 Aug 7. PMID 9708738
  4. E2F transcriptional activation requires TRRAP and GCN5 cofactors. Lang SE, et al. J Biol Chem, 2001 Aug 31. PMID 11418595
  5. Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. Ikura T, et al. Cell, 2000 Aug 18. PMID 10966108

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of SAGA complex ISO
Inferred from Sequence Orthology
more info
  
part_of Swr1 complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFTC complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
transformation/transcription domain-associated protein

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105907.4 → NP_001099377.2  transformation/transcription domain-associated protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A0A8I6AL99
    Conserved Domains (3) summary
    cd05163
    Location:3483 → 3770
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:2833 → 3173
    FAT; FAT domain
    pfam02260
    Location:3819 → 3846
    FATC; FATC domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    14851758..14941444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089172.2 → XP_038945100.1  transformation/transcription domain-associated protein isoform X17

    UniProtKB/TrEMBL
    A0A8I6AL99
    Conserved Domains (3) summary
    COG5032
    Location:2526 → 3847
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:3484 → 3771
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:2832 → 3174
    FAT; FAT domain

  2. XM_063271123.1 → XP_063127193.1  transformation/transcription domain-associated protein isoform X4

    UniProtKB/TrEMBL
    A0A8I6GLC1

  3. XM_039089174.2 → XP_038945102.1  transformation/transcription domain-associated protein isoform X19

    UniProtKB/TrEMBL
    A0A8I6AL99
    Related
    ENSRNOP00000095828.1, ENSRNOT00000076323.4
    Conserved Domains (3) summary
    COG5032
    Location:2527 → 3848
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:3485 → 3772
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:2833 → 3175
    FAT; FAT domain

  4. XM_063271132.1 → XP_063127202.1  transformation/transcription domain-associated protein isoform X14

    UniProtKB/TrEMBL
    A0A8I6GLC1

  5. XM_063271128.1 → XP_063127198.1  transformation/transcription domain-associated protein isoform X10

    UniProtKB/TrEMBL
    A0A8I6GLC1

  6. XM_039089173.2 → XP_038945101.1  transformation/transcription domain-associated protein isoform X18

    UniProtKB/TrEMBL
    A0A8I6AL99
    Related
    ENSRNOP00000095357.2, ENSRNOT00000030545.9
    Conserved Domains (3) summary
    COG5032
    Location:2545 → 3877
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:3514 → 3801
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:2851 → 3204
    FAT; FAT domain

  7. XM_063271125.1 → XP_063127195.1  transformation/transcription domain-associated protein isoform X7

    UniProtKB/TrEMBL
    A0A8I6GLC1

  8. XM_063271124.1 → XP_063127194.1  transformation/transcription domain-associated protein isoform X6

    UniProtKB/TrEMBL
    A0A8I6GLC1

  9. XM_063271134.1 → XP_063127204.1  transformation/transcription domain-associated protein isoform X16

    UniProtKB/TrEMBL
    A0A8I6AL99

  10. XM_063271127.1 → XP_063127197.1  transformation/transcription domain-associated protein isoform X9

    UniProtKB/TrEMBL
    A0A8I6GLC1, A0ABK0M266
    Related
    ENSRNOP00000111242.1, ENSRNOT00000166774.1

  11. XM_063271133.1 → XP_063127203.1  transformation/transcription domain-associated protein isoform X15

    UniProtKB/TrEMBL
    A0A8I6AL99

  12. XM_063271126.1 → XP_063127196.1  transformation/transcription domain-associated protein isoform X8

    UniProtKB/TrEMBL
    A0A8I6GLC1

  13. XM_063271131.1 → XP_063127201.1  transformation/transcription domain-associated protein isoform X13

    UniProtKB/TrEMBL
    A0A8I5Y6J8, A0A8I6AL99
    Related
    ENSRNOP00000076944.2, ENSRNOT00000091346.3

  14. XM_039089162.2 → XP_038945090.1  transformation/transcription domain-associated protein isoform X5

    UniProtKB/TrEMBL
    A0A8I6GLC1
    Conserved Domains (3) summary
    COG5032
    Location:2552 → 3910
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:3521 → 3834
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:2858 → 3211
    FAT; FAT domain

  15. XM_063271122.1 → XP_063127192.1  transformation/transcription domain-associated protein isoform X3

    UniProtKB/TrEMBL
    A0A8I6GLC1

  16. XM_039089168.2 → XP_038945096.1  transformation/transcription domain-associated protein isoform X12

    UniProtKB/TrEMBL
    A0A8I6AL99
    Conserved Domains (3) summary
    COG5032
    Location:2552 → 3885
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:3522 → 3809
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:2858 → 3211
    FAT; FAT domain

  17. XM_063271130.1 → XP_063127200.1  transformation/transcription domain-associated protein isoform X11

    UniProtKB/TrEMBL
    A0A8I6AL99

  18. XM_039089159.2 → XP_038945087.1  transformation/transcription domain-associated protein isoform X2

    UniProtKB/TrEMBL
    A0A8I6GLC1
    Conserved Domains (3) summary
    COG5032
    Location:2552 → 3911
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05163
    Location:3522 → 3835
    PIKK_TRRAP; Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein
    pfam02259
    Location:2858 → 3211
    FAT; FAT domain

  19. XM_063271119.1 → XP_063127189.1  transformation/transcription domain-associated protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6GLC1

  20. XM_063271121.1 → XP_063127191.1  transformation/transcription domain-associated protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6GLC1
Nucleotide Protein Strain
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