Ca15 carbonic anhydrase 15 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ca15provided by RGD
Official Full Name: carbonic anhydrase 15provided by RGD
Primary source: RGD:1306018
See related: Ensembl:ENSRNOG00000037983 AllianceGenome:RGD:1306018
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Car15
Summary: Predicted to enable carbonate dehydratase activity. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Expression: Biased expression in Kidney (RPKM 72.1), Brain (RPKM 4.3) and 1 other tissue See more
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Genomic context

Location:: 11q23

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (96651439..96654384)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (83147155..83150101)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (87293827..87298690)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carbonate dehydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carbonate dehydratase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: carbonic anhydrase 15

NP_001099371.1

EC 4.2.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105901.1 → NP_001099371.1 carbonic anhydrase 15 precursor

See identical proteins and their annotated locations for NP_001099371.1

Status: PROVISIONAL

Source sequence(s)

CH473999

UniProtKB/TrEMBL

A6JSK0, D3ZBQ6

Related

ENSRNOP00000000312.5, ENSRNOT00000000312.7

Conserved Domains (1) summary

cd03117
Location:47 → 290

alpha_CA_IV_XV_like; Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...