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GPX7 glutathione peroxidase 7 [ Homo sapiens (human) ]

Gene ID: 2882, updated on 5-Dec-2018

Summary

Official Symbol
GPX7provided by HGNC
Official Full Name
glutathione peroxidase 7provided by HGNC
Primary source
HGNC:HGNC:4559
See related
Ensembl:ENSG00000116157 MIM:615784
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPX6; CL683; GPx-7; NPGPx; GSHPx-7
Expression
Ubiquitous expression in placenta (RPKM 15.6), thyroid (RPKM 9.2) and 24 other tissues See more
Orthologs

Genomic context

See GPX7 in Genome Data Viewer
Location:
1p32.3
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (52602371..52609051)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (53068043..53074723)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene terminal uridylyl transferase 4 Neighboring gene uncharacterized LOC105378723 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene 7 Neighboring gene shisa like 2A Neighboring gene cytochrome c oxidase assembly factor 7 (putative)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with GPX7; predicted interaction to be within the endoplasmic reticulum and function as thioredoxin reductase PubMed
Tat tat HIV-1 Tat causes a greater than 50% decrease in intracellular reduced glutathione (GSH), leading to the extracellular appearance of acidic FGF-1, an effect that is partially mediated through modulation of GSH biosynthetic enzymes PubMed
tat Expression of HIV-1 Tat in HeLa cells downregulates cytoplasmic glutathione peroxidase while upregulating phospholipid hydroperoxide glutathione peroxidase, thereby deregulating intracellular oxidant/antioxidant balance and amplifying UV sensitivity PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14777

Gene Ontology Provided by GOA

Function Evidence Code Pubs
catalase activity IDA
Inferred from Direct Assay
more info
PubMed 
glutathione peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
peroxidase activity EXP
Inferred from Experiment
more info
PubMed 
peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
cellular response to oxidative stress TAS
Traceable Author Statement
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
glutathione peroxidase 7
Names
glutathione peroxidase 6
non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase
NP_056511.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015696.5NP_056511.2  glutathione peroxidase 7 precursor

    See identical proteins and their annotated locations for NP_056511.2

    Status: VALIDATED

    Source sequence(s)
    AK027683, BI550170, BU627166
    Consensus CDS
    CCDS569.1
    UniProtKB/Swiss-Prot
    Q96SL4
    Related
    ENSP00000354677.4, ENST00000361314.4
    Conserved Domains (1) summary
    TIGR02540
    Location:24176
    gpx7; putative glutathione peroxidase Gpx7

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    52602371..52609051
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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