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Mylk myosin light chain kinase [ Rattus norvegicus (Norway rat) ]

Gene ID: 288057, updated on 13-Aug-2019

Summary

Official Symbol
Mylkprovided by RGD
Official Full Name
myosin light chain kinaseprovided by RGD
Primary source
RGD:1310915
See related
Ensembl:ENSRNOG00000002215
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Uterus (RPKM 657.5), Lung (RPKM 530.3) and 8 other tissues See more
Orthologs

Genomic context

See Mylk in Genome Data Viewer
Location:
11q22
Exon count:
35
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (69013060..69260039, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 11 NC_005110.3 (72103710..72350517, complement)

Chromosome 11 - NC_005110.4Genomic Context describing neighboring genes Neighboring gene adenylate cyclase 5 Neighboring gene uncharacterized LOC108352344 Neighboring gene 3-hydroxyacyl-CoA dehydratase 2 Neighboring gene very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 2-like Neighboring gene kxDL motif-containing protein 1-like Neighboring gene non-histone chromosomal protein HMG-17-like Neighboring gene coiled-coil domain containing 14 Neighboring gene rhophilin associated tail protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Pathways from BioSystems

  • Apelin signaling pathway, organism-specific biosystem (from KEGG)
    Apelin signaling pathway, organism-specific biosystemApelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various ti...
  • Calcium signaling pathway, organism-specific biosystem (from KEGG)
    Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Calcium signaling pathway, conserved biosystem (from KEGG)
    Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Focal Adhesion, organism-specific biosystem (from WikiPathways)
    Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, organism-specific biosystem (from KEGG)
    Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, conserved biosystem (from KEGG)
    Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Gastric acid secretion, organism-specific biosystem (from KEGG)
    Gastric acid secretion, organism-specific biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
  • Gastric acid secretion, conserved biosystem (from KEGG)
    Gastric acid secretion, conserved biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
  • Muscle contraction, organism-specific biosystem (from REACTOME)
    Muscle contraction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Oxytocin signaling pathway, organism-specific biosystem (from KEGG)
    Oxytocin signaling pathway, organism-specific biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • Oxytocin signaling pathway, conserved biosystem (from KEGG)
    Oxytocin signaling pathway, conserved biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • Platelet activation, organism-specific biosystem (from KEGG)
    Platelet activation, organism-specific biosystemPlatelets play a key and beneficial role for primary hemostasis on the disruption of the integrity of vessel wall. Platelet adhesion and activation at sites of vascular wall injury is initiated by ad...
  • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
    RHO GTPase Effectors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • RHO GTPases activate PAKs, organism-specific biosystem (from REACTOME)
    RHO GTPases activate PAKs, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
    Regulation of Actin Cytoskeleton, organism-specific biosystem
    Regulation of Actin Cytoskeleton
  • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
    Regulation of actin cytoskeleton, organism-specific biosystem
    Regulation of actin cytoskeleton
  • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
    Regulation of actin cytoskeleton, conserved biosystem
    Regulation of actin cytoskeleton
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Smooth Muscle Contraction, organism-specific biosystem (from REACTOME)
    Smooth Muscle Contraction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
    Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
  • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
    Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
  • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
    cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
  • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
    cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
PubMed 
myosin light chain kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
myosin light chain kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
aorta smooth muscle tissue morphogenesis IEA
Inferred from Electronic Annotation
more info
 
aorta smooth muscle tissue morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
bleb assembly IEA
Inferred from Electronic Annotation
more info
 
bleb assembly ISO
Inferred from Sequence Orthology
more info
PubMed 
cardiovascular system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular hypotonic response IEA
Inferred from Electronic Annotation
more info
 
cellular hypotonic response ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to calcium ion ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to drug ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to potassium ion ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of wound healing IEA
Inferred from Electronic Annotation
more info
 
positive regulation of wound healing ISO
Inferred from Sequence Orthology
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
smooth muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
PubMed 
tonic smooth muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tonic smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction ISO
Inferred from Sequence Orthology
more info
PubMed 
cleavage furrow IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cleavage furrow ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lamellipodium ISO
Inferred from Sequence Orthology
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stress fiber ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
myosin light chain kinase, smooth muscle
Names
myosin, light polypeptide kinase
NP_001099344.2
XP_006248495.1
XP_006248496.1
XP_008766933.1
XP_008766934.1
XP_017453410.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105874.2NP_001099344.2  myosin light chain kinase, smooth muscle

    Status: VALIDATED

    Source sequence(s)
    AABR07034408, AABR07034409
    UniProtKB/TrEMBL
    D3ZFU9
    Related
    ENSRNOP00000062274.2, ENSRNOT00000067060.2
    Conserved Domains (8) summary
    cd00096
    Location:183251
    Ig; Immunoglobulin domain
    smart00408
    Location:523586
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:13741465
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:18521942
    I-set; Immunoglobulin I-set domain
    cd14191
    Location:15041762
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    pfam00069
    Location:15071762
    Pkinase; Protein kinase domain
    pfam16620
    Location:255408
    23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
    cl11960
    Location:12811378
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005110.4 Reference Rnor_6.0 Primary Assembly

    Range
    69013060..69260039 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008768711.2XP_008766933.1  myosin light chain kinase, smooth muscle isoform X2

    Conserved Domains (8) summary
    cd00096
    Location:627695
    Ig; Immunoglobulin domain
    smart00408
    Location:514577
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:13651456
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:18421932
    I-set; Immunoglobulin I-set domain
    cd14191
    Location:14951753
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    pfam00069
    Location:14981753
    Pkinase; Protein kinase domain
    pfam16620
    Location:246399
    23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
    cl11960
    Location:12721369
    Ig; Immunoglobulin domain
  2. XM_017597921.1XP_017453410.1  myosin light chain kinase, smooth muscle isoform X1

    UniProtKB/TrEMBL
    A0A0G2K0Q7
    Conserved Domains (8) summary
    cd00096
    Location:627695
    Ig; Immunoglobulin domain
    smart00408
    Location:514577
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:13651456
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:18431933
    I-set; Immunoglobulin I-set domain
    cd14191
    Location:14951753
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    pfam00069
    Location:14981753
    Pkinase; Protein kinase domain
    pfam16620
    Location:246399
    23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
    cl11960
    Location:12721369
    Ig; Immunoglobulin domain
  3. XM_008768712.2XP_008766934.1  myosin light chain kinase, smooth muscle isoform X3

    Conserved Domains (6) summary
    cd05762
    Location:38135
    Ig8_MLCK; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK)
    smart00408
    Location:622689
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:131222
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:609699
    I-set; Immunoglobulin I-set domain
    pfam00069
    Location:264519
    Pkinase; Protein kinase domain
    cl21453
    Location:261519
    PKc_like; Protein Kinases, catalytic domain
  4. XM_006248434.3XP_006248496.1  myosin light chain kinase, smooth muscle isoform X1

    See identical proteins and their annotated locations for XP_006248496.1

    UniProtKB/TrEMBL
    A0A0G2K0Q7
    Conserved Domains (8) summary
    cd00096
    Location:627695
    Ig; Immunoglobulin domain
    smart00408
    Location:514577
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:13651456
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:18431933
    I-set; Immunoglobulin I-set domain
    cd14191
    Location:14951753
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    pfam00069
    Location:14981753
    Pkinase; Protein kinase domain
    pfam16620
    Location:246399
    23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
    cl11960
    Location:12721369
    Ig; Immunoglobulin domain
  5. XM_006248433.3XP_006248495.1  myosin light chain kinase, smooth muscle isoform X1

    See identical proteins and their annotated locations for XP_006248495.1

    UniProtKB/TrEMBL
    A0A0G2K0Q7
    Related
    ENSRNOP00000071545.1, ENSRNOT00000085618.1
    Conserved Domains (8) summary
    cd00096
    Location:627695
    Ig; Immunoglobulin domain
    smart00408
    Location:514577
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:13651456
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:18431933
    I-set; Immunoglobulin I-set domain
    cd14191
    Location:14951753
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    pfam00069
    Location:14981753
    Pkinase; Protein kinase domain
    pfam16620
    Location:246399
    23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
    cl11960
    Location:12721369
    Ig; Immunoglobulin domain

Alternate Rn_Celera

Genomic

  1. AC_000079.1 Alternate Rn_Celera

    Range
    65239196..65448599 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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